| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Thålin, Charlotte, et al.
(författare)
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Elevated Troponin Levels in Acute Stroke Patients Predict Long-term Mortality
- 2015
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Ingår i: Journal of Stroke & Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057 .- 1532-8511. ; 10, s. 285-286
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Forskningsöversikt (refereegranskat)abstract
- Background: Elevated plasma levels of troponin in acute stroke patients are common and have in several studies been shown to predict in-hospital and short-term mortality. Little is, however, known about the long-term prognosis of these patients. The aim of this study was to determine patient characteristics and 5-year mortality in patients with acute stroke and troponin elevation on admission. Methods: A retrospective cohort study of all consecutive patients with acute stroke and a plasma troponin I (TnI) analyzed on admission to Danderyd Hospital between January 1, 2005, and January 1, 2006 (n = 247). Patient characteristics were obtained from the Swedish National Stroke Register, Riksstroke, as well as hospital records. Mortality data were obtained from the Swedish Cause of Death Register. Results: There were 133 patients (54%) with TnI less than .03 mu g/L (normal), 74 patients (30%) with TnI .03-.11 mu g/L (low elevation), and 40 patients (16%) with TnI greater than .11 mu g/L (high elevation). TnI elevations were associated with a higher age, prior ischemic stroke, chronic heart failure, renal insufficiency, stroke severity, and ST segment elevation or depression on admission. The rate of hyperlipidemia decreased with increasing TnI. Adjusted for age and comorbidity, elevated TnI values on admission had a significantly and sustained increased mortality over the 5-year follow-up, with a hazard ratio of 1.90 (95% confidence interval, 1.33-2.70). Conclusions: Troponin elevation in patients with acute stroke, even when adjusted for several possible confounders, is associated with an almost 2-fold increased risk of 5-year mortality.
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| 5. |
- Carlier, Charlotte, et al.
(författare)
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Preclinical activity of melflufen (J1) in ovarian cancer
- 2016
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:37, s. 59322-59335
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Tidskriftsartikel (refereegranskat)abstract
- Ovarian cancer carries a significant mortality. Since symptoms tend to be minimal, the disease is often diagnosed when peritoneal metastases are already present. The standard of care in advanced ovarian cancer consists of platinum-based chemotherapy combined with cytoreductive surgery. Unfortunately, even after optimal cytoreduction and adjuvant chemotherapy, most patients with stage III disease will develop a recurrence. Intraperitoneal administration of chemotherapy is an alternative treatment for patients with localized disease. The pharmacological and physiochemical properties of melflufen, a peptidase potentiated alkylator, raised the hypothesis that this drug could be useful in ovarian cancer and particularily against peritoneal carcinomatosis. In this study the preclinical effects of melflufen were investigated in different ovarian cancer models. Melflufen was active against ovarian cancer cell lines, primary cultures of patient-derived ovarian cancer cells, and inhibited the growth of subcutaneous A2780 ovarian cancer xenografts alone and when combined with gemcitabine or liposomal doxorubicin when administered intravenously. In addition, an intra-and subperitoneal xenograft model showed activity of intraperitoneal administered melflufen for peritoneal carcinomatosis, with minimal side effects and modest systemic exposure. In conclusion, results from this study support further investigations of melflufen for the treatment of peritoneal carcinomatosis from ovarian cancer, both for intravenous and intraperitoneal administration.
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| 8. |
- Kim, Joo Chan, 1989-, et al.
(författare)
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Multidisciplinary Development Process of a Story-based Mobile Augmented Reality Game for Learning Math
- 2019
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Ingår i: Proceedings on the 17th International Conference on Emerging eLearning Technologies and Applications. - : IEEE. ; , s. 372-377
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Konferensbidrag (refereegranskat)abstract
- Despite the high number of educational games released, only a few games have a strong story that is more than an excuse for players’ actions. Furthermore, even fewer story-based games utilise the affordances of augmented reality (AR) to concretise abstract concepts while engaging players.Based on our literature review, we were inspired to merge AR into a story-based educational mobile game for teaching fractions to elementary school students. The game Tales & Fractions was created through a two-phase multidisciplinary development process. In order to successfully integrate AR into a story-based educational game, we employed an adapted version of the Scrum agile software development method implemented by a multidisciplinary team of experts from computer science, pedagogy, design and arts. During the development process, we faced many issues that other story-based AR game developers could meet. We summarised the encountered issues with our solutions which could be useful for developers to avoid common pitfalls and to enrich the user engagement.
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| 9. |
- Lagercrantz, Anne, et al.
(författare)
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Källkritik och krig : propaganda, desinformation och lögner
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Krigsrapporteringen från Ukraina utmanar redaktionernas resurser för att kontrollera vad som är sant och falskt. I rapporten Källkritik och krig presenteras en granskning av hur redaktionerna hanterar desinformation och säkerställer trovärdighet i svenska mediers rapportering under krigets sex första veckor. Slutsatsen är att det är ovanligt att redaktionerna verifierar den egna rapporteringen, vilket istället överlåts på utländska nyhetsbyråer och medier. Den övervägande delen av den svenska bevakningen görs på distans.Rapporten visar också hur Ryssland sedan flera år systematiskt skadar, smädar och styr bilden av Sverige. En direktrapport från Ukraina ger en inblick i hur oklar strategin är för den inhemska bevakningen av kriget.Institutet för mediestudier vill med den här rapporten fördjupa diskussionen om källkritik och faktagranskning i krigs- och konfliktapportering.
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