SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Nylander E) "

Sökning: WFRF:(Nylander E)

  • Resultat 1-10 av 73
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Mahajan, Anubha, et al. (författare)
  • Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
  • 2018
  • Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 50:11, s. 1505-
  • Tidskriftsartikel (refereegranskat)abstract
    • We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci,135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%,14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Börjesson, Mats, 1965, et al. (författare)
  • Plötslig död och idrott
  • 2008
  • Ingår i: FYSS Folkhälsoinstitutet, 2nd Ed. ; , s. 145-51
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  • Gu, Xiaolian, 1976-, et al. (författare)
  • Little effect on p63 but significant effect on miR-21 and miR-125b by NB-UVB phototherapy on psoriatic lesions
  • 2010
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Psoriasis is an inflammatory skin disease in which dysregulation of p63, a member of the p53 family and crucial for skin development and maintenance, has been shown. Though currently incurable, many therapies are available including narrowband ultraviolet B (NB-UVB) phototherapy. To further elucidate the role of p63 in psoriasis and increase our understanding of the mechanisms of phototherapy, we studied the effects of NB-UVB treatment on p63 expression. Expression of p53 was also studied due to its functional role in the response of skin to UV. In addition, we investigated expression of miR-203, miR-125b and miR-21, as these microRNAs are p63 and/or p53 regulators and their involvement in psoriasis pathogenesis has previously been suggested. Skin biopsies from 12 psoriasis patients were collected before, during and at the final session of phototherapy. Real time RT-PCR and immunohistochemistry showed that epidermal p63 mRNA and protein levels were not significantly affected following phototherapy, whereas a significant increase in p53 mRNA expression and protein accumulation was found. NB-UVB treatment also significantly affected expression of miR-21 and miR-125b, whereas individual clinical improvement seemed related to p53 status only. Our results indicate that even though NB-UVB phototherapy causes diverse molecular changes, induction of p53 is pivotal for successful treatment of psoriasis, and unresolved p63 abnormality in the treated epidermis of psoriasis patients further indicate a role for p63 in psoriasis.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 73
Typ av publikation
tidskriftsartikel (56)
konferensbidrag (13)
bokkapitel (2)
annan publikation (1)
doktorsavhandling (1)
Typ av innehåll
refereegranskat (57)
övrigt vetenskapligt/konstnärligt (16)
Författare/redaktör
Nylander, E (19)
Nylander, Tommy (7)
Börjesson, Mats, 196 ... (4)
Larsson, Ingrid, 196 ... (4)
Bremander, Ann, 1957 ... (4)
Nylander, Ingrid (3)
visa fler...
Fredriksson, I (3)
Jayaram-Lindstrom, N (3)
Dahlström, Ulf, 1946 ... (3)
Wahlgren, Marie (3)
Nylander, Eva, 1951- (3)
Nylander, Eva (3)
Larsson, Johan (3)
Wilander, E (3)
Lindqvist, E (3)
Ulvenlund, Stefan (3)
Nylander, Maria (3)
Sanchez-Fernandez, A ... (3)
Nylander, Karin (3)
Dellborg, Mikael, 19 ... (2)
Groop, Leif (2)
Johansson, G. (2)
Warfvinge, Gunnar (2)
Terenius, L (2)
Adolfsson, R. (2)
Ekholm, B (2)
Goiny, M (2)
Dahlström, Ulf (2)
Holm, Lena (2)
Lindholm, E. (2)
McCarthy, Mark I (2)
Karlsson, J-E (2)
Boehnke, Michael (2)
Mohlke, Karen L (2)
Salo, T (2)
Bergman, Birgitta (2)
Pettersson, U. (2)
Ininbergs, Karolina (2)
Allen, Andrew E. (2)
Mahajan, Anubha (2)
Nylander, Vibe (2)
Gloyn, Anna L (2)
Ungerstedt, U (2)
HERRERAMARSCHITZ, M (2)
Hedman, K (2)
Bouma, K (2)
Mandic, M (2)
Rullman, E (2)
Nylander, Johan A. A ... (2)
Pettersson, E (2)
visa färre...
Lärosäte
Karolinska Institutet (21)
Uppsala universitet (14)
Lunds universitet (12)
Umeå universitet (10)
Linköpings universitet (10)
Göteborgs universitet (8)
visa fler...
Högskolan i Halmstad (5)
Malmö universitet (4)
Naturhistoriska riksmuseet (3)
Stockholms universitet (2)
Örebro universitet (2)
Chalmers tekniska högskola (2)
Kungliga Tekniska Högskolan (1)
Luleå tekniska universitet (1)
Högskolan i Gävle (1)
Jönköping University (1)
Linnéuniversitetet (1)
RISE (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (71)
Svenska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (26)
Naturvetenskap (12)
Teknik (2)
Lantbruksvetenskap (2)
Samhällsvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy