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- Bergström, Göran, 1964, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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- Löfgren, Eva, 1971, et al.
(författare)
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Forskning och kunskapsutveckling Svenska kyrkans materiella kulturarv 2015-2022
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Vilka forskare och kunskapsaktörer arbetar med Svenska kyrkans materiella kulturarv idag, vilka teman dominerar fältet och hur förhåller de sig till tidigare forskning? Det är frågor som besvaras i denna översikt, som tar sin utgångspunkt i en systematisk genomgång av aktuella forsknings- och kunskapsprojekt. Syftet är att identifiera, beskriva och diskutera den forskning och kunskap om Svenska kyrkans materiella kulturarv som har producerats i akademiska miljöer under åren 2015-2022. Översikten omfattar publicerade resultat (artiklar, rapporter, böcker, filmer) och examensarbeten, men tar också upp pågående projekt. Den inkluderar arbeten som har tillkommit i samverkan mellan ett lärosäte och kunskapsaktörer inom kulturmiljösektorn eller Svenska kyrkan, eller som på annat sätt har stark anknytning till en akademisk miljö. Några internationella nedslag görs i syfte att ge perspektiv på den svenska forskningens inriktning och luckor. Arbetet utgör en fortsättning på översikten som presenterades 2014 (Persson mfl. 2014).
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- Nyström, Maria, et al.
(författare)
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Interaction of adipose-derived stem cells with active and dormant breast cancer cells
- 2023
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Ingår i: Journal of Plastic, Reconstructive & Aesthetic Surgery. - : Elsevier. - 1748-6815 .- 1878-0539. ; 83, s. 69-76
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although autologous fat grafting is considered a successful method for the management of contour deformities, the fat graft could potentially induce cancer reappearance by fueling dormant breast cancer cells. Our aim was to characterize the role of adipose-derived stem cells on active and dormant breast cancer cell growth.Methods: Cobalt chloride was used to induce dormancy in MCF-7 cancer cells. Proliferation of active and dormant cancer cells was determined in the presence of adipose-derived stem cells. A proteome array was used to detect cancer-related protein expression in the cell-conditioned medium. The migration of cancer cells was measured in response to conditioned medium from the adipose-derived stem cells.Results: The adipose-derived stem cells showed variable effects on active MCF-7 cells growth and inhibited MCF-7 proliferation after the withdrawal of cobalt chloride. Of the 84 different proteins measured in the conditioned medium, only tenascin-C was differentially expressed in the co-cultures. MCF-7 cells alone did not express tenascin-C, whereas co-cultures between MCF-7 and adipose-derived stem cells expressed more tenascin-C versus adipose-derived stem cells alone. The conditioned medium from co-cultures significantly increased the migration of the cancer cells.Conclusions: Adipose-derived stem cells themselves neither increased the growth or migration of cancer cells, suggesting that autologous fat grafting may be oncologically safe if reconstruction is postponed until there is no evidence of active disease. However, interactions between adipose-derived stem cells and MCF-7 cancer cells could potentially lead to the production of factors, which further promote cancer cell migration.
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- Nyström, Maria, 1988
(författare)
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Managing Ecclesiastical Heritage - Transformation of Discourses, Roles and Policy in Sweden
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Religious heritage is in a state of transformation. Changing religious practices and secularization affect the established Christian congregations in many countries, as membership decreases and churches close. During recent years, new approaches to use and develop churches have been explored by the heritage field and the Christian congregations. A parallel development in heritage theory and policy focuses on broad definitions of heritage and questions the position of the heritage expert. In Sweden, the ecclesiastical heritage has a prominent position through heritage legislation and the shared management model of the State and Church. Departing from two case studies of projects that explore new approaches to heritage management, the purpose of the thesis is to describe how ecclesiastical heritage is constructed and understood by public heritage institutions and the Church of Sweden. In addition, the thesis aims to describe how professional and institutional roles and responsibilities are constructed and understood within the field. The case studies cover two contemporary projects involving the built ecclesiastical heritage in Sweden: the Cathedral Hill Project in Strängnäs and the Hamra Project in the village of Hamra. The projects unite actors from the public heritage field and the Church of Sweden and aim to develop and extend the use and management of the church. Adopting a qualitative approach, the material consists of interviews with key actors, documents, and observations of the case studies. Synchronic discourse analysis is applied to identify discourses on heritage and understand the roles of the actors. The results reveal parallel discourses on heritage among the actors, which are constructed through coinciding and conflicting values on the management of the past. Conflicting values may be negotiated to reach consensus, while different interpretations of governing frameworks and objectives cause tension between actors. The institutional roles and responsibilities of the key actors provide different capacities to incorporate policy strategies in practice. Despite the difficulties of balancing the objectives of the organizational framework of public heritage management, the actors use the available resources and tools to transform the boundaries of their institutional roles from within.
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