| 1. |
- Alirezaie, Marjan, et al.
(författare)
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SmartEnv ontology in E-care@home (Short paper)
- 2018
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Ingår i: CEUR Workshop Proceedings. - : CEUR-WS. ; , s. 72-79, s. 72-79
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Konferensbidrag (refereegranskat)abstract
- In this position paper we briey introduce SmartEnv ontology which relies on SEmantic Sensor Network (SSN) ontology and is used to represent different aspects of smart and sensorized environments. We will also talk about E-carehome project aiming at providing an IoT-based health-care system for elderly people at their homes. Furthermore, we refer to the role of SmartEnv in Ecarehome and how it needs to be further extended to achieve semantic interoperability as one of the challenges in development of autonomous health care systems at home.
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| 2. |
- Nordén, Rickard, 1977, et al.
(författare)
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Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T cells: Involvement of host and viral factors.
- 2013
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Ingår i: Glycobiology. - : Oxford University Press (OUP). - 1460-2423 .- 0959-6658. ; 23:3, s. 310-321
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Tidskriftsartikel (refereegranskat)abstract
- Circulating leukocytes that express selectin ligands such as the carbohydrate epitope sialyl Lewis X (sLeX) may interact with endothelial selectins, resulting in transmigration of the leukocyte across the endothelial wall to adjacent tissue. Due to the potential of selectin-ligand interactions as targets in viral pathogenesis, we aimed at determining whether herpes simplex virus type 1 (HSV1) is able to induce appearance of sLeX at the surface of infected leukocytes. We found that HSV1 infection of a T cell line resulted in transcriptional activation of human fucosyltransferase genes FUT3, FUT6 and FUT7, the two latter genes encoding fucosyltransferases rate limiting for sLeX synthesis. Flow cytometry and confocal microscopy demonstrated that HSV1 infection resulted in a two-fold rise in the proportion of sLeX-positive cells. Increased levels of FUT3, FUT6 and FUT7 RNA were detected already at 3 h post infection, and treatment with cycloheximide, a translation inhibitor, blocked HSV1-induced increase in expression of FUT3, FUT6 and FUT7 RNA, suggesting involvement of viral or cellular proteins. Studies with infectious viral mutants indicated that the viral immediate early (α) protein ICP0 is essential for initiation of FUT7 though not for FUT3 or FUT6 transcription. In CD3+ cells, derived from peripheral blood mononuclear cells, HSV1 infection induced expression of FUT3, FUT5 and FUT6, whereas FUT7 was not altered. The mean sLeX fluorescence intensity of CD3+ cells was significantly higher in HSV1-infected CD3+ cells. This suggests that infected leukocytes during HSV1 viremia may express selectin ligands with possible but as yet unproven roles in viral pathogenesis.
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| 3. |
- Santini, Marina, 1960-, et al.
(författare)
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Can We quantify domainhood? : Exploring measures to assess domain-specificity in web corpora
- 2018
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Ingår i: Commun. Comput. Info. Sci.. - Cham : Springer International Publishing. - 9783319991320 - 9783319991337 ; , s. 207-217
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Konferensbidrag (refereegranskat)abstract
- Web corpora are a cornerstone of modern Language Technology. Corpora built from the web are convenient because their creation is fast and inexpensive. Several studies have been carried out to assess the representativeness of general-purpose web corpora by comparing them to traditional corpora. Less attention has been paid to assess the representativeness of specialized or domain-specific web corpora. In this paper, we focus on the assessment of domain representativeness of web corpora and we claim that it is possible to assess the degree of domain-specificity, or domainhood, of web corpora. We present a case study where we explore the effectiveness of different measures - namely the Mann-Withney-Wilcoxon Test, Kendall correlation coefficient, Kullback–Leibler divergence, log-likelihood and burstiness - to gauge domainhood. Our findings indicate that burstiness is the most suitable measure to single out domain-specific words from a specialized corpus and to allow for the quantification of domainhood.
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| 4. |
- Santini, Marina, et al.
(författare)
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Designing an Extensible Domain-Specific Web Corpus for “Layfication” : A Case Study in eCare at Home
- 2019
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Ingår i: Cyber-Physical Systems for Social Applications. - Hershey, PA, USA : IGI Global. - 9781522593454 - 9781522578802 ; , s. 98-155
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Bokkapitel (refereegranskat)abstract
- In the era of data-driven science, corpus-based language technology is an essential part of cyber physical systems. In this chapter, the authors describe the design and the development of an extensible domain-specific web corpus to be used in a distributed social application for the care of the elderly at home. The domain of interest is the medical field of chronic diseases. The corpus is conceived as a flexible and extensible textual resource, where additional documents and additional languages will be appended over time. The main purpose of the corpus is to be used for building and training language technology applications for the “layfication” of the specialized medical jargon. “Layfication” refers to the automatic identification of more intuitive linguistic expressions that can help laypeople (e.g., patients, family caregivers, and home care aides) understand medical terms, which often appear opaque. Exploratory experiments are presented and discussed.
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| 5. |
- Adelöf, Anna, et al.
(författare)
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Förvaltning av SNOMED CT som en del i det nationella fackspråket för vård och omsorg
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- Förvaltningsrapporten fokuserar på Snomed CT, eftersom det redan i dag finns rutiner för förvaltningar av termbanken och nationella hälsorelaterade klassifikationer. Ett särskilt utvecklingsarbete kommer att krävas för dessa delar.Rapporten tar upp syfte och mål med förvaltningen. Utöver det redogör rapporten för vilka konkreta ansvarsområden som ingår i förvaltningen av Snomed CT. Målet för förvaltningen är att Socialstyrelsen regelbundet ska kunna tillhandahålla en kontrollerad och uppdaterad release av Snomed CT. Det skulle möjliggöra användning inom vård och omsorg. Rapporten tar även upp behovet av kompetens, utbildning och finansiella resurser.
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| 6. |
- Barlow, Lotti, et al.
(författare)
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Nationellt fackspråk för vård och omsorg : Slutrapport
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- SammanfattningEtt tillgängligt och använt nationellt fackspråk ska bidra till en god och säker vård och omsorg. Det ska även medverka till att kvaliteten och resultaten på området ska kunna följas upp och jämföras på ett mer effektivt sätt. Slutrapporten presenterar resultatet av projektet Nationellt fackspråk för vård och omsorg samt förslag till förvaltning och utveckling.ResultatetResultatet innefattar bland annat att det internationella begreppssystemet Snomed CT är översatt till svenska och att det är förberett för förvaltning och distribution. Socialstyrelsen har även tagit fram och testat metoder för förvaltning och utveckling av det nationella fackspråket i sin helhet. Därtill har representanter för målgrupperna informerats och fått kunskap.Rapporten innehåller en utförlig beskrivning av det nationella fackspråkets sammantagna innehåll: Socialstyrelsens termbank, klassifikationer och kodverk, den svenska versionen av Snomed CT, metoder för utveckling och förvaltning samt regler för användning.Förvaltning, införande och resursbehovI rapporten finns förslag till hur hela det nationella fackspråket kan tas omhand av Socialstyrelsen och hur det kan införas i vården och omsorgen. Projektets övergång till en långsiktigt hållbar organisation kräver resurser. Därför redogör rapporten för det förväntade resursbehovet för förvaltning och utveckling. Bland annat föreslås en treårig utbildningsinsats samt stimulansbidrag för införande.Krav på styrning, samordning och förtydligat ansvarRapporten betonar behovet av en samlad och medveten styrning av utvecklingen inom området. Socialstyrelsen vill ha en samordnande roll i utvecklingen och förvaltningen av det nationella fackspråket. Myndigheten föreslås få det initiala ansvaret för att utbilda användare och att driva frågor om det nationella fackspråket.Vidare vill Socialstyrelsen få ett uttalat mandat att samordna de nationella aktiviteter som drivs med koppling till Snomed CT. Rapporten pekar ut några särskilt prioriterade områden som myndigheten borde få i uppdrag att arbeta vidare inom.Kunskapsstyrning och normgivningEn viktig slutsats i rapporten är att användningen av det nationella fackspråket behöver regleras för att målet om ökad säkerhet för klienter och patienter ska kunna uppnås. I dagsläget bedöms föreskrifter vara den metod som bäst kan garantera ett brett genomförande.Målgrupper för slutrapportenSlutrapporten riktar sig till beslutsfattare i kommuner och landsting, vård- och omsorgspersonal med särskilt intresse eller ansvar för dokumentationsfrågor och professionella organisationer. Den riktar sig också till terminologiansvariga i kommuner och landsting, IT-direktörer, IT-leverantörer samt aktörer inom den nationella strategin för eHälsa.
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| 7. |
- Baud, Robert, et al.
(författare)
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Interchanging Lexical information for a multilingual dictionary
- 2005
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Ingår i: AMIA Annual Symposium Proceedings. - Washington DC : AMIA Symposium; American Medical Informatics Association. ; , s. 31-35
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Konferensbidrag (refereegranskat)abstract
- OBJECTIVE:To facilitate the interchange of lexical information for multiple languages in the medical domain. To pave the way for the emergence of a generally available truly multilingual electronic dictionary in the medical domain.METHODS:An interchange format has to be neutral relative to the target languages. It has to be consistent with current needs of lexicon authors, present and future. An active interaction between six potential authors aimed to determine a common denominator striking the right balance between richness of content and ease of use for lexicon providers.RESULTS:A simple list of relevant attributes has been established and published. The format has the potential for collecting relevant parts of a future multilingual dictionary. An XML version is available.CONCLUSION:This effort makes feasible the exchange of lexical information between research groups. Interchange files are made available in a public repository. This procedure opens the door to a true multilingual dictionary, in the awareness that the exchange of lexical information is (only) a necessary first step, before structuring the corresponding entries in different languages.
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| 8. |
- Cornet, Ronald, et al.
(författare)
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User-Directed Coordination in SNOMED CT
- 2013
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Ingår i: MedInfo 2013. - Amsterdam : IOS Press. - 9781614992882 ; , s. 72-76
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Konferensbidrag (refereegranskat)abstract
- The possibility of post-coordination of SNOMED CT concepts, especially by clinical users, is both an asset and a challenge for SNOMED CT implementation. To get insight in the applicability of post-coordination, we analyzed scenarios for user-directed coordination that are described in the documentation of SNOMED CT. The analyses were based on experiences from previous and ongoing research and implementation work, including national mapping projects, and investigations on collection of data for multiple uses. These scenarios show various usability and representation problems: high number of relationships for refinement and qualification, improper options for refinement, incorrect formal definitions, and lack of support for applying editorial rules. Improved user-directed coordination in SNOMED CT in real practice requires advanced sanctioning, increased consistency of definitions of concepts in SNOMED CT, and real-time analysis of the post-coordinate expression.
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| 9. |
- Holm, Tua, et al.
(författare)
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Lessons learned from starting to implement SNOMED CT
- 2014
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- National eHealth – the strategy for accessible and secure information in health and social care – is a Swedish initiative aiming at improving information management within the healthcare and social services sector. SNOMED CT is one tool in this strategy. To gain experience from SNOMED CT implementation, the National Board of Health and Welfare (host of the National Release Center of SNOMED CT) funded a number of pilot projects during 2013. Our project was one of these, focusing on facilitation of information sharing by using SNOMED CT in two application areas as described below. Furthermore, the project initiated a dialog with the EHR vendor concerning future SNOMED CT implementation.One area was transfer of discharge summaries from hospital care at Östergötland County Council to municipal home care. A discharge summary consists of a template with encoded headings, associated free text fields, and instructions about intended content. These headings were mapped to SNOMED CT.The other area was transfer of information from the EHR system at hospitals in three counties to the Swedish Stroke Register, a national quality register. The specification of information requested by the register was analyzed. Then, an EHR template was outlined, taking into account the clinical stroke process requirements, quality register requirements, and the information model of the EHR system. The draft template was based on mappings to SNOMED CT to facilitate a mutually agreed template. That means a template common for the three county councils, as well as information transfer to the register, and at the same time reduce the need for double documentation, information searching and other manual routines.Lessons learned include that mapping EHR template components and other EHR objects to SNOMED CT concepts holds potential benefits, regardless of whether one’s EHR system can handle mappings. Mapping activities may aid review and management of existing and development of new templates. Furthermore, mappings may be used as a common point of reference when information is shared. Mapping ambiguous template headings to SNOMED CT concepts was found to be time consuming and uncertain and mapping seems to be most useful when EHR contents are structured. These mapping source prerequisites imply that existing documentation practice needs to be revised and that organizations must support end users in that process. The project also concluded that mappings would be even more advantageous if EHR systems can handle mappings of different objects types. Organizations also need to allocate adequate resources for managing its own mappings as well as contributing to the development of SNOMED CT as such.Finally, the project found that training of mapping personnel benefits from integrating theoretical instruction and practical use of SNOMED CT, and that finding the correct concept in SNOMED CT calls for clinical expertise in order to be successful.
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| 10. |
- Hägglund, Maria, Lektor, 1975-, et al.
(författare)
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Världsbäst på eHälsa kräver internationellt samarbete
- 2017
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Ingår i: Svenska dagbladet. - Stockholm, Sweden : Svenska Dagbladet AB & Co.. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Det är glädjande att myndigheter nu äntligen tittar mer på internationellt delade detaljerade dokumentationsmodeller för innehåll i journaler. Vi hoppas att de ger tillräckligt kraftfulla och tydliga budskap så att de upphandlande vårdgivarna också ser vikten av detta. Om vi ska bli världsbäst på eHälsa krävs internationellt samarbete, skriver flera forskare i medicinsk informatik.
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