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Sökning: WFRF:(O'Brien Lucy Erin)

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1.
  • Cao, Junyue, et al. (författare)
  • Principles of Systems Biology, No. 21
  • 2017
  • Ingår i: CELL SYSTEMS. - : CELL PRESS. - 2405-4712. ; 5:3, s. 158-160
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • This month: relating single cells to populations (Cao/Packer, Wu/Altschuler, O'Brien, Friedman), an excess of ribosomes (Barkai), human pathology atlas (Uhlen), signatures of feedback (Rahi), and major genome redesign (Baumgart).
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2.
  • Cao, Junyue, et al. (författare)
  • Principles of Systems Biology, No. 21 : Editorial
  • 2017
  • Ingår i: CELL SYSTEMS. - : Elsevier BV. - 2405-4712. ; 5:3, s. 158-160
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • This month: relating single cells to populations (Cao/Packer, Wu/Altschuler, O'Brien, Friedman), an excess of ribosomes (Barkai), human pathology atlas (Uhlen), signatures of feedback (Rahi), and major genome redesign (Baumgart).
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3.
  • Kim, Anna A., et al. (författare)
  • Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ
  • 2022
  • Ingår i: Journal of Cell Science. - : The Company of Biologists. - 0021-9533 .- 1477-9137. ; 135:14
  • Tidskriftsartikel (refereegranskat)abstract
    • Cytosolic Ca2+ is a highly dynamic, tightly regulated and broadly conserved cellular signal. Ca2+ dynamics have been studied widely in cellular monocultures, yet organs in vivo comprise heterogeneous populations of stem and differentiated cells. Here, we examine Ca2+ dynamics in the adult Drosophila intestine, a self-renewing epithelial organ in which stem cells continuously produce daughters that differentiate into either enteroendocrine cells or enterocytes. Live imaging of whole organs ex vivo reveals that stem-cell daughters adopt strikingly distinct patterns of Ca2+ oscillations after differentiation: enteroendocrine cells exhibit single-cell Ca2+ oscillations, whereas enterocytes exhibit rhythmic, long-range Ca2+ waves. These multicellular waves do not propagate through immature progenitors (stem cells and enteroblasts), of which the oscillation frequency is approximately half that of enteroendocrine cells. Organ-scale inhibition of gap junctions eliminates Ca2+ oscillations in all cell types – even, intriguingly, in progenitor and enteroendocrine cells that are surrounded only by enterocytes. Our findings establish that cells adopt fate-specific modes of Ca2+ dynamics as they terminally differentiate and reveal that the oscillatory dynamics of different cell types in a single, coherent epithelium are paced independently.
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  • Resultat 1-3 av 3

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