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- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
- Antel, C., et al.
(författare)
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Feebly-interacting particles : FIPs 2022 Workshop Report
- 2023
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Ingår i: European Physical Journal C. - : Springer. - 1434-6044 .- 1434-6052. ; 83:12
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Forskningsöversikt (refereegranskat)abstract
- Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs.
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| 6. |
- Kos, K., et al.
(författare)
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DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue : DPP-IV inhibition in human adipose tissue
- 2009
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Ingår i: Diabetes Obes Metab. - 1463-1326. ; 11:4, s. 285-92
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Dipeptidyl peptidase IV (DPP-IV) inactivates the incretin hormone glucagon-like peptide. It can also affect the orexigenic hormone neuropeptide Y (NPY(1-36)) which is truncated by DPP-IV to NPY(3-36), as a consequence NPY's affinity changes from receptor Y1, which mediates the antilipolytic function of NPY, to other NPY receptors. Little is known whether DPP-IV inhibitors for the treatment of type 2 diabetic (T2DM) patients could influence these pathways. AIMS: To investigate the in vitro effects of NPY with DPP-IV inhibition in isolated abdominal subcutaneous (AbdSc) adipocytes on fat metabolism, and assessment of NPY receptor and DPP-IV expression in adipose tissue (AT). METHODS: Ex vivo human AT was taken from women undergoing elective surgery (body mass index: 27.5 (mean +/- s.d.) +/- 5 kg/m2, age: 43.7 +/- 10 years, n = 36). Isolated AbdSc adipocytes were treated with human recombinant (rh)NPY (1-100 nM) with and without DPP-IV inhibitor (1 M); glycerol release and tissue distribution of DPP-IV, Y1 and Y5 messenger RNA (mRNA) were measured and compared between lean and obese subjects. RESULTS AND CONCLUSION: rhNPY reduced glycerol release, an effect that was further enhanced by co-incubation with a DPP-IV inhibitor [control: 224 (mean +/- s.e.) +/- 37 micromol/l; NPY, 100 nM: 161 +/- 27 micromol/l**; NPY 100 nM/DPP-IV inhibitor, 1 M: 127 +/- 14 micromol/l**; **p < 0.01, n = 14]. DPP-IV was expressed in AbdSc AT and omental AT with relative DPP-IV mRNA expression lower in AbdSc AT taken from obese [77 +/- 6 signal units (SU)] vs. lean subjects (186 +/- 29 SU*, n = 10). Y1 was predominantly expressed in fat and present in all fat depots but higher in obese subjects, particularly the AbdSc AT-depot (obese: 1944 +/- 111 SU vs. lean: 711 +/- 112 SU**, n = 10). NPY appears to be regulated by AT-derived DPP-IV. DPP-IV inhibitors augment the antilipolytic effect of NPY in AT. Further studies are required to show whether this explains the lack of weight loss in T2DM patients treated with DPP-IV inhibitors.
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- O'Hare, C. A. J., et al.
(författare)
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Axion helioscopes as solar magnetometers
- 2020
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 102:4
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Tidskriftsartikel (refereegranskat)abstract
- Axion helioscopes search for solar axions and axionlike particles via inverse Primakoff conversion in strong laboratory magnets pointed at the Sun. Anticipating the detection of solar axions, we determine the potential for the planned next-generation helioscope, the International Axion Observatory (IAXO), to measure or constrain the solar magnetic field. To do this we consider a previously neglected component of the solar axion flux at sub-keV energies arising from the conversion of longitudinal plasmons. This flux is sensitively dependent to the magnetic field profile of the Sun, with lower energies corresponding to axions converting into photons at larger solar radii. If the detector technology eventually installed in IAXO has an energy resolution better than 200 eV, then solar axions could become an even more powerful messenger than neutrinos of the magnetic field in the core of the Sun. For energy resolutions better than 10 eV, IAXO could access the inner 70% of the Sun and begin to constrain the field at the tachocline: the boundary between the radiative and convective zones. The longitudinal plasmon flux from a toroidal magnetic field also has an additional 2% geometric modulation effect which could be used to measure the angular dependence of the magnetic field.
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