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- Burri, Stina, et al.
(författare)
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Processed meat products with added plant antioxidants affect the microbiota and immune response in C57BL/6JRj mice with cyclically induced chronic inflammation
- 2021
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Ingår i: Biomedicine and Pharmacotherapy. - : Elsevier BV. - 1950-6007 .- 0753-3322. ; 135
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Tidskriftsartikel (refereegranskat)abstract
- Epidemiological studies have found that there is a correlation between red and processed meat consumption and an increased risk of colorectal cancer. There are numerous existing hypotheses on what underlying mechanisms are causative to this correlation, but the results remain unclear. A common hypothesis is that lipid oxidation, which occurs in endogenous lipids and phospholipids in consumed food, are catalyzed by the heme iron in meat. In this study, five pre-selected plant antioxidant preparations (sea buckthorn leaves and sprouts, summer savory leaves, olive polyphenols, onion skin and lyophilized black currant leaves) were added to a meatball type prone to oxidize (pork meat, 20 % fat, 2% salt, deep-fried and after 2 weeks of storage). Pro-inflammatory markers, neutrophil infiltration and microbiota composition were studied after four months in a chronic inflammation model in C57BL6/J female mice. We found that the bacterial diversity index was affected, as well as initial immunological reactions.
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- Olsson, B, et al.
(författare)
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Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes
- 2003
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Ingår i: American Journal of Physiology: Endocrinology and Metabolism. - : American Physiological Society. - 1522-1555 .- 0193-1849. ; 285:3, s. 504-511
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Tidskriftsartikel (refereegranskat)abstract
- Transgenic mice overexpressing growth hormone (GH) have been extensively used to study the chronic effects of elevated serum levels of GH. GH is known to have many acute effects in the liver, but little is known about the chronic effects of GH overexpression on hepatic gene expression. Therefore, we used DNA microarray to compare gene expression in livers from bovine GH (bGH)-transgenic mice and littermates. Hepatic expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) and genes involved in fatty acid activation, peroxisomal and mitochondrial beta-oxidation, and production of ketone bodies was decreased. In line with this expression profile, bGH-transgenic mice had a reduced ability to form ketone bodies in both the fed and fasted states. Although the bGH mice were hyperinsulinemic, the expression of sterol regulatory element-binding protein (SREBP)-1 and most lipogenic enzymes regulated by SREBP-1 was reduced, indicating that these mice are different from other insulin-resistant models with respect to expression of SREBP-1 and its downstream genes. This study also provides several candidate genes for the well-known association between elevated GH levels and cardiovascular disease, e.g., decreased expression of scavenger receptor class B type I, hepatic lipase, and serum paraoxonase and increased expression of serum amyloid A-3 protein. We conclude that bGH-transgenic mice display marked changes in hepatic genes coding for metabolic enzymes and suggest that GH directly or indirectly regulates many of these hepatic genes via decreased expression of PPARalpha and SREBP-1.
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- QUIST, AP, et al.
(författare)
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A SCANNING FORCE MICROSCOPY STUDY OF HUMAN SERUM-ALBUMIN AND PORCINE PANCREAS TRYPSIN ADSORPTION ON MICA SURFACES
- 1995
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Ingår i: Surface Science. - MALARDALEN UNIV,DEPT CHEM ENGN,S-63105 ESKILSTUNA,SWEDEN. UNIV UPPSALA,CTR BIOCHEM SEPARAT,S-75123 UPPSALA,SWEDEN. : ELSEVIER SCIENCE BV. - 0039-6028 .- 1879-2758. ; 325:1-2, s. L406-L412
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Tidskriftsartikel (refereegranskat)abstract
- Scanning force microscopy is more and more expanding as a tool for biological research. Here we report about the observation of molecular adsorption on mica surfaces. Human serum albumin and porcine pancreas trypsin were adsorbed on freshly cleaved mica from the solution phase, The new tapping mode (intermittent contact) scanning force microscopy technique was employed to image the molecules on the surface. We observed clusters of molecules and features which we interpret as single molecules adsorbed on the mica. For albumin, we could sometimes resolve structures corresponding to the three main domains of which albumin is composed. Analysis of lateral sizes and height, as well as scanning artefacts, are discussed. We observed the ability of the tapping mode to modify the distances between the respective domains in albumin and to split clusters into smaller parts.
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- Quist, AP, et al.
(författare)
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Site-selective molecular adsorption at nanometer-scale MeV-atomic-ion-induced surface defects
- 1997
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Ingår i: JOURNAL OF COLLOID AND INTERFACE SCIENCE. - : ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS. ; 189:1
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The adsorption of Escherichia coli beta-galactosidase (beta Gal) onto mica surfaces that had been irradiated with fast atomic ions was studied with both ambient and liquid cell tapping mode scanning force microscopy (TM-SFM). The single-ion-impacts result
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