↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Obreque C) "

Sökning: WFRF:(Obreque C)

Resultat 1-3 av 3

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	2017 swepub:Mat__t
2.	Bonaca, MP, et al. (författare) Long-term use of ticagrelor in patients with prior myocardial infarction 2015 Ingår i: The New England journal of medicine. - 1533-4406. ; 372:19, s. 1791-1800 Tidskriftsartikel (refereegranskat)
3.	Garcia, P, et al. (författare) Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer 2020 Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 12:4 Tidskriftsartikel (refereegranskat)abstract Gallbladder cancer is an aggressive disease with late diagnosis and no efficacious treatment. The Hippo-Yes-associated protein 1 (YAP1) signaling pathway has emerged as a target for the development of new therapeutic interventions in cancers. However, the role of the Hippo-targeted therapy has not been addressed in advanced gallbladder cancer (GBC). This study aimed to evaluate the expression of the major Hippo pathway components mammalian Ste20-like protein kinase 1 (MST1), YAP1 and transcriptional coactivator with PDZ-binding motif (TAZ) and examined the effects of Verteporfin (VP), a small molecular inhibitor of YAP1-TEA domain transcription factor (TEAD) protein interaction, in metastatic GBC cell lines and patient-derived organoids (PDOs). Immunohistochemical analysis revealed that advanced GBC patients had high nuclear expression of YAP1. High nuclear expression of YAP1 was associated with poor survival in GBC patients with subserosal invasion (pT2). Additionally, advanced GBC cases showed reduced expression of MST1 compared to chronic cholecystitis. Both VP treatment and YAP1 siRNA inhibited the migration ability in GBC cell lines. Interestingly, gemcitabine resistant PDOs with high nuclear expression of YAP1 were sensitive to VP treatment. Taken together, our results suggest that key components of the Hippo-YAP1 signaling pathway are dysregulated in advanced gallbladder cancer and reveal that the inhibition YAP1 may be a candidate for targeted therapy.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-3 av 3

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Chen, Y. (2); Garcia, C. (2); Hu, D. (2); Zhu, J. (2); Nelson, S. (2); Diaz, R. (2); visa fler...; Costa, M. (2); Dellborg, M (2); Ito, S (2); Aboyans, V (2); Rodriguez, J. (2); Yang, X. (2); Foerster, A. (2); Johansson, K (2); Lee, J. (2); Reyes, M. (2); Suzuki, A. (2); Suzuki, K. (2); Abe, Y (2); Medina, F (2); Kis, E. (2); Anderson, J (2); Sharma, M. (2); Torres, M. (2); Thompson, P. (2); Kim, E (2); Saraiva, J. (2); Hasegawa, K (2); Brown, C (2); Bordoni, P (2); Kim, C. (2); Smith, K. (2); Rodriguez, A (2); Ferrari, E. (2); Rodriguez, M (2); Collins, N (2); Singh, B (2); Volkov, V. (2); Castoldi, M. (2); Ohashi, Y (2); Dong, Y. (2); Hidalgo, J (2); Jacobs, C (2); Lindberg, A (2); Nakano, A. (2); Goto, S. (2); Hashimoto, Y (2); Hashimoto, T (2); Lanas, F. (2); Morales, D (2); visa färre...

Lärosäte: Karolinska Institutet (3)

Språk: Engelska (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy