| 1. |
- Jardin, Fabrice, et al.
(författare)
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Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma.
- 2016
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Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 91:9, s. 923-30
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Tidskriftsartikel (refereegranskat)abstract
- Primary mediastinal B-cell lymphoma (PMBL) is an entity of B-cell lymphoma distinct from the other molecular subtypes of diffuse large B-cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin-β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced and the XPO1 mutational status was correlated to genetic and clinical characteristics. The XPO1 mutational status was also assessed in DLBCL, Hodgkin lymphoma (HL) and mediastinal gray-zone lymphoma (MGZL).The biological impact of the mutation on Selective Inhibitor of Nuclear Export (SINE) compounds (KPT-185/330) sensitivity was investigated in vitro. XPO1 mutations were present in 28/117 (24%) PMBL cases and in 5/19 (26%) HL cases but absent/rare in MGZL (0/20) or DLBCL (3/197). A higher prevalence (50%) of the recurrent codon 571 variant (p.E571K) was observed in GEP-defined PMBL and was associated with shorter PFS. Age, International Prognostic Index and bulky mass were similar in XPO1 mutant and wild-type cases. KPT-185 induced a dose-dependent decrease in cell proliferation and increased cell-death in PMBL cell lines harboring wild type or XPO1 E571K mutant alleles. Experiments in transfected U2OS cells further confirmed that the XPO1 E571K mutation does not have a drastic impact on KPT-330 binding. To conclude the XPO1 E571K mutation represents a genetic hallmark of the PMBL subtype and serves as a new relevant PMBL biomarker. SINE compounds appear active for both mutated and wild-type protein. Am. J. Hematol. 91:923-930, 2016. © 2016 Wiley Periodicals, Inc.
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| 2. |
- Arvidsson, Emma, et al.
(författare)
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Pattern and orientation of diffusers in rooms with an absorbent ceiling
- 2019
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Ingår i: Proceedings of the 23rd International Congress on Acoustics : Integrating 4th EAA Euroregio 2019 - Integrating 4th EAA Euroregio 2019. - 2226-7808 .- 2415-1599. - 9783939296157 ; 2019-September, s. 2281-2288
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Konferensbidrag (refereegranskat)abstract
- Lately have the demands on good room acoustics in public ordinary rooms increased. Traditionally has only reverberation time been considered in this type of rooms but complementary parameters as sound strength and speech clarity are more commonly used today. This trend naturally implies higher demands on the acoustic treatment. Typical for public ordinary rooms is to use an absorbent ceiling. One way to further improve the acoustic properties is to complement the ceiling treatment with diffusers. To investigate the effect of combining these two types of acoustic treatments have measurements been carried out combing different setups of diffusers in a reverberant room with an absorbent ceiling. The impact on reverberation time, speech clarity and sound strength has been studied. In this paper we present how diffusers can be used in order to improve the acoustic properties in a public ordinary room with an absorbent ceiling and how the pattern and orientation of diffusers can be used to adjust different acoustic parameters.
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| 3. |
- Jay, Raphael, et al.
(författare)
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Following Metal-to-Ligand Charge-Transfer Dynamics with Ligand and Spin Specificity Using Femtosecond Resonant Inelastic X-ray Scattering at the Nitrogen K-Edge
- 2021
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Ingår i: The Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 12:28, s. 6676-6683
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate for the case of photoexcited [Ru(2,2'-bipyridine)(3)](2+) how femtosecond resonant inelastic X-ray scattering (RIXS) at the ligand K-edge allows one to uniquely probe changes in the valence electronic structure following a metal-to-ligand charge-transfer (MLCT) excitation. Metal-ligand hybridization is probed by nitrogen-1s resonances providing information on both the electron-accepting ligand in the MLCT state and the hole density of the metal center. By comparing to spectrum calculations based on density functional theory, we are able to distinguish the electronic structure of the electron-accepting ligand and the other ligands and determine a temporal upper limit of (250 +/- 40) fs for electron localization following the charge-transfer excitation. The spin of the localized electron is deduced from the selection rules of the RIXS process establishing new experimental capabilities for probing transient charge and spin densities.
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| 4. |
- Vardaxis, Nikolaos Georgios, et al.
(författare)
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Acoustic comfort assessment in heavyweight residential buildings : Acoustic data associated to subjective responses
- 2019
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Ingår i: Proceedings of the 23rd International Congress on Acoustics : Integrating 4th EAA Euroregio 2019 - Integrating 4th EAA Euroregio 2019. - 2226-7808 .- 2415-1599. - 9783939296157 ; 2019-September, s. 836-843
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Konferensbidrag (refereegranskat)abstract
- This article presents a study aiming to explore and evaluate acoustic comfort in residential multistory buildings in Sweden. Acoustic data was associated to self-reported responses acquired by a survey: a questionnaire was setup researching the response to noise annoyance from multiple sources in a flat and the emotional reactions of tenants to the acoustic climate at home. An assessment of acoustic comfort in the test apartments was performed utilizing the circumplex model of affect. A sample of 353 residents offered their ratings on 12 bipolar scales regarding their feelings towards their living sound environment. Two dimensions were identified: pleasantness and activation. Statistical models were developed using acoustic and structural variables. L'#$,&,'((predicted best pleasantness and number of flats per building predicted best activation. A new acoustic comfort indicator is suggested based on the pleasantness model and four novel acoustic comfort classes are proposed as: AC-1: Very good, AC-2: Good, AC-3: Acceptable, AC-4: No comfort.
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