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- Lohmander, L. Stefan, et al.
(författare)
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Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee : A randomised, double blind, placebo controlled multicentre trial
- 1996
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967. ; 55:7, s. 424-431
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Tidskriftsartikel (refereegranskat)abstract
- Objective - To assess the effects of intraarticular injections of hyaluronan on symptoms of knee osteoarthritis (OA). Methods - Two hundred and forty patients with symptomatic, radiological knee OA were randomly assigned to treatment with weekly injections for five weeks with either 25 mg of high molecular weight hyaluronan or vehicle. Results were evaluated at weeks 1, 2, 3, 4, 5, 13, and 20 by visual analogue scales (pain, function, motion, activity), algofunctional index, and global evaluation by patient and investigator. Analysis was by 'intention to treat', 'per protocol), and area under the curve principles on unstratified patient groups and for patients stratified into four groups of equal size by age and baseline algofunctional index. Results - No serious side effects were reported. At 20 weeks both treatment groups were improved compared with baseline, with no difference between unstratified groups treated with placebo or hyaluronan. Comparison of treatment-groups stratified by age and baseline algofunctional index revealed a significant-difference in favour of hyaluronan over placebo (pain, activity, algofunctional index, global evaluations by patient-and investigator) for patients older than 60 years and with a baseline algofunctional index greater than 10. There was no clinically relevant difference between the two treatments for the other three stratified subgroups of younger age or fewer symptoms. Similar results were obtained by area under the curve, intention to treat, and per protocol analysis. Conclusions-Patients older than 60 years with knee osteoarthritis and with significant symptoms corresponding to an index of severity of knee disease of 10 or more, comprise the group most likely to benefit from treatment with intra-articular hyaluronan injections.
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| 5. |
- Odensten, Magnus, et al.
(författare)
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Knee function and muscle strength following distal ileotibial band transfer for antero-lateral rotatory instability
- 1983
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 54:6, s. 924-928
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Tidskriftsartikel (refereegranskat)abstract
- In a prospective study, 60 consecutive patients underwent a distal iliotibial band transfer for anterolateral knee instability. Knee function was evaluated with a score system, static stability tests and a standardized test including thigh muscle measurements, a one-leg-jump-test and a figure-of-8 running test. At the 40-month follow-up there was a significant increase in the mean knee score. The quadriceps in the treated leg was significantly weaker than in the non-operated leg, and the quadriceps strength was significantly correlated to the knee score. The functional outcome after operation was generally unsatisfactory. Few patients attained normal values in all tests, primarily because of poor restoration of stability.
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| 6. |
- Tegner, Yelverton, et al.
(författare)
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Evaluation of cruciate ligament injuries : A review
- 1988
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 59:3, s. 336-341
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Tidskriftsartikel (refereegranskat)abstract
- A good system for evaluating the degree of impairment, disability, and handicap of the patient with a cruciate ligament injury includes functional score, activity grading, stability testing, and measurements of performance and strength, all of which are relevant to different aspects of knee function. The symptom-related knee score gives a more differentiated picture of the disability than does a binomial rating of symptoms. A way of grading the disability in an objective way is to use a performance test. This test could also be used for monitoring rehabilitation before full activity has been resumed. The activity grading scale is very useful for grading the handicap
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