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- Oggiano, Florian, et al.
(författare)
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Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor.
- 2022
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Ingår i: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. - : Elsevier BV. - 1530-0285. ; 35:6, s. 767-776
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Tidskriftsartikel (refereegranskat)abstract
- Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently recognized soft tissue tumor that is considered to be of borderline malignancy. The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions involving the PRDM10 gene. Previous analyses of PRDM10-rearranged tumors have demonstrated that they have a distinct gene expression profile, resulting in high expression of CADM3 (also known as SynCam3), which can be detected immunohistochemically. Here, we investigated a series (n=43) of SCD34FT or PRDM10-rearranged tumors and potential mimics (n=226) with regard to morphological, genetic, and immunohistochemical features. The results show that SCD34FT and PRDM10-rearranged tumor are morphologically indistinguishable; 41 of 43 tumors of both entities are CADM3-positive. Hence, we suggest that they constitute a single entity, preferably referred to as SCD34FT. Expression of CADM3 was only rarely seen in other soft tissue tumors, except in tumors with Schwann cell differentiation. Thus, IHC for CADM3, in combination with the characteristic morphological features, is a valuable adjunct in the diagnosis of SCD34FT.
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- Supej, Matej, et al.
(författare)
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Aerodynamic drag is not the major determinant of performance during giant slalom skiing at the elite level
- 2013
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley-Blackwell. - 0905-7188 .- 1600-0838. ; 23:1, s. e38-e47
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Tidskriftsartikel (refereegranskat)abstract
- This investigation was designed to (a) develop an individualized mechanical model for measuring aerodynamic drag (Fd) while ski racing through multiple gates, (b) estimate energy dissipation (Ed) caused by Fd and compare this to the total energy loss (Et), and (c) investigate the relative contribution of Ed/Et to performance during giant slalom skiing (GS). Nine elite skiers were monitored in different positions and with different wind velocities in a wind tunnel, as well as during GS and straight downhill skiing employing a Global Navigation Satellite System. On the basis of the wind tunnel measurements, a linear regression model of drag coefficient multiplied by cross-sectional area as a function of shoulder height was established for each skier (r > 0.94, all P < 0.001). Skiing velocity, Fd, Et, and Ed per GS turn were 15–21 m/s, 20–60 N, −11 to −5 kJ, and −2.3 to −0.5 kJ, respectively. Ed/Et ranged from ∼5% to 28% and the relationship between Et/vin and Ed was r = −0.12 (all NS). In conclusion, (a) Fd during alpine skiing was calculated by mechanical modeling, (b) Ed made a relatively small contribution to Et, and (c) higher relative Ed was correlated to better performance in elite GS skiers, suggesting that reducing ski–snow friction can improve this performance.
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