| 1. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of the double-differential high-mass Drell-Yan cross section in pp collisions at root s=8 TeV with the ATLAS detector
- 2016
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :8
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a measurement of the double-differential cross section for the Drell-Yan Z/gamma* -> l(+)l(-) and photon-induced gamma gamma -> l(+)l(-) processes where l is an electron or muon. The measurement is performed for invariant masses of the lepton pairs, m(ll), between 116 GeV and 1500 GeV using a sample of 20.3 fb(-1) of pp collisions data at centre-of-mass energy of root s = 8TeV collected by the ATLAS detector at the LHC in 2012. The data are presented double differentially in invariant mass and absolute dilepton rapidity as well as in invariant mass and absolute pseudorapidity separation of the lepton pair. The single-differential cross section as a function of m(ll) is also reported. The electron and muon channel measurements are combined and a total experimental precision of better than 1% is achieved at low m(ll). A comparison to next-to-next-to-leading order perturbative QCD predictions using several recent parton distribution functions and including next-to-leading order electroweak effects indicates the potential of the data to constrain parton distribution functions. In particular, a large impact of the data on the photon PDF is demonstrated.
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| 4. |
- Bulanova, Daria, et al.
(författare)
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Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
- 2017
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Ingår i: Viruses. - : MDPI AG. - 1999-4915. ; 9:10
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Tidskriftsartikel (refereegranskat)abstract
- Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases.
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| 5. |
- Hibbett, D. S., et al.
(författare)
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Progress in molecular and morphological taxon discovery in Fungi and options for formal classification of environmental sequences
- 2011
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Ingår i: Fungal Biology Reviews. - 1749-4613. ; 25:1, s. 38-47
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Forskningsöversikt (refereegranskat)abstract
- Fungal taxonomy seeks to discover, describe, and classify all species of Fungi and provide tools for their identification. About 100,000 fungal species have been described so far, but it has been estimated that there may be from 1.5 to 5.1 million extant fungal species. Over the last decade, about 1200 new species of Fungi have been described in each year. At that rate, it may take up to 4000 y to describe all species of Fungi using current specimen-based approaches. At the same time, the number of molecular operational taxonomic units (MOTUs) discovered in ecological surveys has been increasing dramatically. We analyzed ribosomal RNA internal transcribed spacer (ITS) sequences in the GenBank nucleotide database and classified them as “environmental” or “specimen-based”. We obtained 91,225 sequences, of which 30,217 (33 %) were of environmental origin. Clustering at an average 93 % identity in extracted ITS1 and ITS2 sequences yielded 16,969 clusters, including 6230 (37 %) clusters with only environmental sequences, and 2223 (13 %) clusters with both environmental and specimen-based sequences. In 2008 and 2009, the number of purely environmental clusters deposited in GenBank exceeded the number of species described based on specimens, and this does not include the huge number of unnamed MOTUs discovered in pyrosequencing studies. To enable communication about fungal diversity, there is a pressing need to develop classification systems based on environmental sequences. Assigning Latin binomials to MOTUs would promote their integration with specimen-based taxonomic databases, whereas the use of numerical codes for MOTUs would perpetuate a disconnect with the taxonomic literature. MOTUs could be formally named under the existing International Code of Botanical Nomenclature if the concept of a nomenclatural type was expanded to include environmental samples or illustrations of sequence chromatograms (or alignments). Alternatively, a “candidate species” category could be created for Fungi, based on the candidatus taxon status employed by microbiologists.
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| 6. |
- Iverson, G. L., et al.
(författare)
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Reliability of serum S100B measurement following mild traumatic brain injury: a comparison of assay measurements from two laboratories
- 2020
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Ingår i: Brain Injury. - : Informa UK Limited. - 0269-9052 .- 1362-301X. ; 34:9, s. 1237-1244
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Tidskriftsartikel (refereegranskat)abstract
- Objective There is enormous research and clinical interest in blood-based biomarkers of mild traumatic brain injury (MTBI) sustained in sports, daily life, or military service. We examined the reliability of a commercially available assay for S100B used on the same samples by two different laboratories separated by 2 years in time. Methods and Procedures A cohort of 163 adult patients (head CT-scanned, n = 110) with mild head injury were enrolled from the emergency department (ED). All had Glasgow Coma Scale scores of 14 or 15 in the ED (94.4% = 15). The mean time between injury and venous blood sampling was 2.9 h (SD = 1.4; Range = 0.5-6.0 h). Serum S100B was measured at two independent centers using the same high throughput clinical assay (Elecsys S100B (R); Roche Diagnostics). Results The Spearman correlation between the two assays in the total sample (N = 163) was r = 0.93. A Wilcoxson Signed Ranks test indicated that the median scores for the values differed (Z = 2,082,p< .001, Cohen's d = 0.151, small effect size). The values obtained from the two laboratories were very similar for identifying traumatic intracranial abnormalities (sensitivity = 80.1% versus 85.7%). Conclusions The serum S100B results measured using the same assay in different laboratories yielded highly correlated and clinically similar, but clearly not identical, results.
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| 7. |
- Iverson, G. L., et al.
(författare)
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Serum Neurofilament Light Is Elevated Differentially in Older Adults with Uncomplicated Mild Traumatic Brain Injuries
- 2019
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Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert Inc. - 0897-7151 .- 1557-9042. ; 36:16
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Tidskriftsartikel (refereegranskat)abstract
- Neurofilament light (NF-L) might have diagnostic and prognostic potential as a blood biomarker for mild traumatic brain injury (mTBI). However, elevated NF-L is associated with several neurological disorders associated with older age, which could confound its usefulness as a traumatic brain injury biomarker. We examined whether NF-L is elevated differentially following uncomplicated mTBI in older adults with pre-injury neurological disorders. In a case-control study, a sample of 118 adults (mean age = 62.3 years, standard deviation [SD] = 22.5, range = 18-100; 52.5% women) presenting to the emergency department (ED) with an uncomplicated mTBI were enrolled. All participants underwent head computed tomography in the ED and showed no macroscopic evidence of injury. The mean time between injury and blood sampling was 8.3 h (median [Md] = 3.5; SD = 13.5; interquartile range [IQR] = 1.9-6.0, range = 0.8-67.4, and 90% collected within 19 h). A sample of 40 orthopedically-injured trauma control subjects recruited from a second ED also were examined. Serum NF-L levels were measured and analyzed using Human Neurology 4-Plex A assay on a HD-1 Single Molecule Array (Simoa) instrument. A high correlation was found between age and NF-L levels in the total mTBI sample (r = 0.80), within the subgroups without pre-injury neurological diseases (r = 0.76) and with pre-injury neurological diseases (r = 0.68), and in the trauma control subjects (r = 0.76). Those with mTBIs and pre-injury neurological conditions had higher NF-L levels than those with no pre-injury neurological conditions (p < 0.001, Cohen's d = 1.01). Older age and pre-injury neurological diseases are associated with elevated serum NF-L levels in patients with head trauma and in orthopedically-injured control subjects.
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| 8. |
- Li, Xiaotian, et al.
(författare)
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Flexible Circuits Based on Aluminum Conductor and Nonwoven Substrate
- 2019
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Ingår i: 2019 IEEE International Flexible Electronics Technology Conference, IFETC 2019. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728117782
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Konferensbidrag (refereegranskat)abstract
- Electronic textiles, integrating functional electronics circuits into fabric materials, are emerging as an important branch of flexible circuits. In this paper, we introduce a novel material combination for electronic textiles that can be used in implementing hybrid electronics. This type of circuits is fabricated by laminating patterned aluminum foils onto a nonwoven substrate in a high-speed roll-to-roll method. An isotropic conductive adhesive and an anisotropic conductive adhesive are used to assemble standard surface mount device components onto the fabricated circuits. The surface mount techniques are characterized by means of contact resistance measurements, component bonding strength tests, circuit bending tests, and scanning electron microscopy. An NFC tag with relative humidity sensing functionality is fabricated to evaluate the fabricated circuits to an electronic system level.
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| 9. |
- Aad, G., et al.
(författare)
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- 2014
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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