| 1. |
- Korkalainen, Henri, et al.
(författare)
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Review and perspective on sleep-disordered breathing research and translation to clinics
- 2024
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Ingår i: SLEEP MEDICINE REVIEWS. - 1087-0792 .- 1532-2955. ; 73
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Forskningsöversikt (refereegranskat)abstract
- Sleep-disordered breathing, ranging from habitual snoring to severe obstructive sleep apnea, is a prevalent public health issue. Despite rising interest in sleep and awareness of sleep disorders, sleep research and diagnostic practices still rely on outdated metrics and laborious methods reducing the diagnostic capacity and preventing timely diagnosis and treatment. Consequently, a significant portion of individuals affected by sleep-disordered breathing remain undiagnosed or are misdiagnosed. Taking advantage of state-of-the-art scientific, technological, and computational advances could be an effective way to optimize the diagnostic and treatment pathways. We discuss state-of-the-art multidisciplinary research, review the shortcomings in the current practices of SDB diagnosis and management in adult populations, and provide possible future directions. We critically review the opportunities for modern data analysis methods and machine learning to combine multimodal information, provide a perspective on the pitfalls of big data analysis, and discuss approaches for developing analysis strategies that overcome current limitations. We argue that large-scale and multidisciplinary collaborative efforts based on clinical, scientific, and technical knowledge and rigorous clinical validation and implementation of the outcomes in practice are needed to move the research of sleep-disordered breathing forward, thus increasing the quality of diagnostics and treatment.
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| 2. |
- Ågerstrand, Marlene, et al.
(författare)
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A call for action : Improve reporting of research studies to increase the scientific basis for regulatory decision-making
- 2018
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Ingår i: Journal of Applied Toxicology. - : Wiley. - 0260-437X .- 1099-1263. ; 38:5, s. 783-785
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Tidskriftsartikel (refereegranskat)abstract
- This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer-reviewed research studies in regulatory decision-making. Moreover, this could improve the reliability and reproducibility of published studies in general and make better use of the resources spent in research.
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| 3. |
- Leander, Jacob, 1987, et al.
(författare)
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Parameter Estimation for Nonlinear Mixed Effects Models Implemented in Mathematica
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In many applications within biology and medicine, measurements are gathered from several entities in the same experiment. This could for example be patients exposed to a treatment or cells measured after stimuli. To characterize the variability in response between entities, the nonlinear mixed effects (NLME) model is a suitable statistical model. An NLME model enables quantification of both within- and between subject variability. The parameter estimation in NLME models is not straightforward, due to the intractable expression of the likelihood function. In this work we present a Mathematica package for parameter estimation in NLME models where the longitudinal model is defined by differential equations. The parameter estimation problem is solved by the first-order conditional estimation (FOCE) method with exact gradients. The package is demonstrated using data from a simulated drug concentration model.
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| 4. |
- Ragnarsdottir, Kristin Vala, et al.
(författare)
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Time of scarcity horizons for technology metals, precious metals, base metals, superalloy metals, battery technology metals and infrastructure materials.
- 2017
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Ingår i: Accelerating the Resource Revolution - WRF 2017 Meeting Report : Geneva, October 24 – 25, 2017 - Geneva, October 24 – 25, 2017. - 9783906177182
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Konferensbidrag (refereegranskat)abstract
- We have built a system dynamics model, WORLD6, that takes into account population, energy extraction, production and need, aspects social behaviour, material and metals recycling and important links to the economy. The model is ground-truthed by comparing with actual supply per person from 1900 till 2015 and run until 2400. Primary scarcity metrics are supply per person and year and stock-in-use per person. Results show that technology metals (antimony, bismuth, selenium, indium, gallium and germanium) will all peak in production before 2100. Precious metals will peak in production earlier, or before 2050. The base metals (copper, zinc) will have a roughly stable supply from 2050 till 2300, whereas the production of lead will be approximately the same from 1960 till 2400 and that of nickel will peak before 2050. The superalloy metals (molybdenum, niobium) will have a stable supply from around 2050 till 2400, but cobalt will be stable from 2100 till 2300 and then decline. The battery metal lithium will peak in production 2010, cobalt will be stable (as stated above) and rare earth´s will rise in use, particularly after 2100. When considering service capital per person (concrete, iron, aluminium, copper) the model predicts steady rise throughout the 21st century, with stabilization in the 22nd century. Our dynamic WORLD6 modelling results give clear indications that for the most important metals that are used in modern technology and in societal infrastructure there are limits and therefore careful circular economy programmes are necessary at the level of every nation so that metals do not become the centre of future conflicts.
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| 5. |
- Sverdrup, Harald, et al.
(författare)
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A System Dynamics Assessment of the Supply of Molybdenum and Rhenium Used for Super-alloys and Specialty Steels, Using the WORLD6 Model
- 2018
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Ingår i: BioPhysical Economics and Resource Quality. - : Springer Science and Business Media LLC. - 2366-0120 .- 2366-0112. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- The extraction, supply, market price and recycling of the metals molybdenum and rhenium were modelled using an integrated system dynamics model. The resource estimates made here resulted in significantly larger estimates than earlier studies for molybdenum. Present molybdenum resources are about 75–80 million ton and about 7 million ton has been mined to date. The ultimately recoverable resources (URR) for molybdenum are about 65 million in primary resources and about 45 million ton in secondary sources, a total of about 111 million ton, and after considering technical extractability, evaluating several hundred different geological deposits, the extractable amount is about 90 million ton. For rhenium, URR is about 21,000 ton contained in mostly in molybdenum and copper, but some come from nickel, wolfram and platinum group metal ores. The model outputs show that molybdenum and rhenium are finite resources, and that they may become exhausted unless the degree of recycling will be significantly improved. Peak production is estimated to take place in 2060 for molybdenum and rhenium, with peak in stocks-in-use around 2090. The molybdenum and rhenium recycling rates are generally low. Both market intervention mechanisms and governance incentives should be used to increase recycling. The metal extraction and ore grades were modelled with good success when tested against observed data. The model predicts a significant decline in molybdenum supply after 2100 under the present demand combined with the present regime of recycling. The supply situation for rhenium is dependent on the situation applicable for molybdenum ore availability and rhenium recycling rate.
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| 6. |
- Sverdrup, Harald, et al.
(författare)
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The WORLD6 Integrated System Dynamics Model: Examples of Results from Simulations
- 2019
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Ingår i: Progress Towards the Resource Revolution. - 9783952140987 ; , s. 68-76
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Bokkapitel (refereegranskat)abstract
- The WORLD6 model is a fully integrated dynamic world systems model. It includes a biophysical global economic model, based on first principles of physics and thermodynamics, forcing it to be fully consistent with the underlying mass- and energy balances. The WORLD6 model first creates value from extraction of natural resources, input of human labour, the efficiency effect of mechanization and automation, the effect of innovation and their use in manufacturing of goods and services, and the secondly does monetization through market mechanisms and debt financing. The model includes 7 different capital stocks for: (1) industrial resource extraction, (2) industrial manufacture, (3) social service capital, (4) agricultural capital for land use and food production, (5) military capital, (6) speculative capital tied up in derivatives, real estate, consumer credits, (7) criminal or illegal capital. There are 3 different debt pools; (1) general, (2) speculative and (3) pensions. These are all linked through a number of feedbacks in the system to resource extraction, energy production, population dynamics, food production and phosphorus extraction, manufacture of consumer goods and services. The WORLD6 model connects to environmental pollution with feedbacks and inputs to human health and climate change inside the model. The model includes money flows, stocks as well as debt dynamics and how this is connected to the capital base and the governance. The WORLD6 model has earlier been extensively tested on natural resource extraction rates, resource ore grades, supply volumes and market price for resources with very good success. The WORLD6 model system was tested in its economic aspects against observed GDP for the period 1850 to 2015 and GDP per capita, commodity prices, extraction rates and resource supply rates with good success. These results were obtained from first principles only and without calibrating the model to any type of data time-series.
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| 7. |
- Sverdrup, Harald, et al.
(författare)
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The WORLD6 model for evaluation of natural resource sustainability considering metals, materials, energy, population and food.
- 2017
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Ingår i: Accelerating the Resource Revolution : WRF 2017 Meeting Report, Geneva, October 24 – 25, 2017 - WRF 2017 Meeting Report, Geneva, October 24 – 25, 2017. - 9783906177182
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Konferensbidrag (refereegranskat)abstract
- A new model; WORLD6 was developed. WORLD6 differs from the earlier system dynamics world models in several aspects. Several modules link the economy, materials, metals, energy, population and politics in a dynamic system. The present version is a result of a dismantling of the World3 model (Meadows et al., 1972, 1992, 2004) with an extension and substitution of its resource module and economy module. The WORLD6 model has several sub-modules at present which are all dynamically linked: 1. Population and food module: The module contains the original World3 model from 1972 model and used again in 1992 and 2004. This was enhanced with a new module for phosphate rock extraction, fertilizer production and an agricultural unit of WORLD6. 2. Materials and metals module a. Materials: Phosphorus, cement, sand, gravel and cut stone. b. Metals: Copper, zinc, lead, silver, gold, Iron, chromium, manganese, nickel, aluminium, stainless steel, antimony, bismuth, cobalt, gallium, germanium, indium, cadmium, tellurium, selenium, lithium, platinum, palladium, rhodium, molybdenum, rhenium, niobium, tantalum, tin, wolfram (tungsten), titanium, zirconium, hafnium and rare earth metals.3. Economy module: The model has a new simplified global economy module, considering the major actors like households, businesses, and government. Disposable funds, investments and market price for every resource is simulated endogenously in the model for every resource: metals, materials, food and commodities. 4. Energy module: An energy model including the extraction of fossil fuels. Different types of oil, gas, and coal as well as the extraction dynamics and reprocessing of uranium and thorium, used in conventional and breeder reactor technologies, technological energy harvests and renewable energy. 5. Climate and biosphere module: A simplified CLIMATE change module, converting CO2 emissions to CO2 in the atmosphere, with increase in temperature and sea level rise.
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