| 1. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Bartalesi, A., et al.
(författare)
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Status of the Front Ends project at MAXIV
- 2016
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Ingår i: IPAC 2016 - Proceedings of the 7th International Particle Accelerator Conference. - 9783954501472 ; , s. 2947-2949
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Konferensbidrag (refereegranskat)abstract
- The MAX IV laboratory is a Swedish national laboratory for synchrotron radiation hosted by the Lund University. It will operate two storage rings to produce synchrotron light of very high intensity and quality over a broad wavelength range. A linear accelerator will feed these storage rings in topping up mode as well as serve as an electron source for a short pulse facility built on its extension. The storage rings have different sizes and operate at different energies: the MAX IV 1.5 GeV ring has 12 straight sections optimized for soft x-rays; while the MAX IV 3.0 GeV ring, has 20 straight sections, optimized for harder x-rays. In the initial stage of the project, five beamlines are foreseen to operate on the 3.0 GeV storage ring and an additional five on the 1.5 GeV ring. Each beamline requires a front end to interface the different characteristics in terms of vacuum level, heat loads, radiation safety, beam size and position, with respect to the storage ring. This paper describes the status of the different Front Ends project at MAXIV.
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| 5. |
- da Silva, Humberto, Jr., et al.
(författare)
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Multiple electron capture, excitation, and fragmentation in C6+-C-60 collisions
- 2014
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 90:3, s. 032701-
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Tidskriftsartikel (refereegranskat)abstract
- We present experimental and theoretical results on single- and multiple-electron capture, and fragmentation, in C6+ + C-60 collisions at velocities in the v(col) = 0.05 - 0.4 a.u. range. We use time-of-flight mass spectrometry and coincidence detection of charged fragments to separate pure target ionization from processes in which the C-60 target is both ionized and fragmented. The coincidence technique allows us to identify different types of fragmentation processes such as C-60(q+) -> C-58(q+) + C-2 and C-60(q+) -> C-58((q-1)+) + C-2(+). A quasimolecular approach is employed to calculate charge transfer and target excitation cross sections. First-order time-dependent perturbation and statistical methods are used to treat the postcollisional processes: the calculated rate constants for C-2 and C-2(+) emission from the excited and charged fullerene are then used to evaluate the fragmentation dynamics. We show that the target ionization cross section decreases with the induced target charge state and the impact energy. C-2 emission from C-60(q+) is found to dominate when q <= 2 while C-2(+) emission dominates when q >= 5, in agreement with the present and previous experimental results.
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| 9. |
- Sandén, Emma, et al.
(författare)
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Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
- 2017
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7, s. 46366-
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Tidskriftsartikel (refereegranskat)abstract
- Medulloblastomas comprise a heterogeneous group of tumours and can be subdivided into four molecular subgroups (WNT, SHH, Group 3 and Group 4) with distinct prognosis, biological behaviour and implications for targeted therapies. Few experimental models exist of the aggressive and poorly characterized Group 3 tumours. In order to establish a reproducible transplantable Group 3 medulloblastoma model for preclinical therapeutic studies, we acquired a patient-derived tumour sphere culture and inoculated low-passage spheres into the cerebellums of NOD-scid mice. Mice developed symptoms of brain tumours with a latency of 17–18 weeks. Neurosphere cultures were re-established and serially transplanted for 3 generations, with a negative correlation between tumour latency and numbers of injected cells. Xenografts replicated the phenotype of the primary tumour, including high degree of clustering in DNA methylation analysis, high proliferation, expression of tumour markers, MYC amplification and elevated MYC expression, and sensitivity to the MYC inhibitor JQ1. Xenografts maintained maintained expression of tumour-derived VEGFA and stromal-derived COX-2. VEGFA, COX-2 and c-Myc are highly expressed in Group 3 compared to other medulloblastoma subgroups, suggesting that these molecules are relevant therapeutic targets in Group 3 medulloblastoma.
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