| 1. |
- Bagdonaite, Ieva, et al.
(författare)
-
Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection
- 2023
-
Ingår i: Nature Communications. - 2041-1723. ; 14:1
-
Tidskriftsartikel (refereegranskat)abstract
- Viral and host glycans represent an understudied aspect of host-pathogen interactions, despite potential implications for treatment of viral infections. This is due to lack of easily accessible tools for analyzing glycan function in a meaningful context. Here we generate a glycoengineered keratinocyte library delineating human glycosylation pathways to uncover roles of specific glycans at different stages of herpes simplex virus type 1 (HSV-1) infectious cycle. We show the importance of cellular glycosaminoglycans and glycosphingolipids for HSV-1 attachment, N-glycans for entry and spread, and O-glycans for propagation. While altered virion surface structures have minimal effects on the early interactions with wild type cells, mutation of specific O-glycosylation sites affects glycoprotein surface expression and function. In conclusion, the data demonstrates the importance of specific glycans in a clinically relevant human model of HSV-1 infection and highlights the utility of genetic engineering to elucidate the roles of specific viral and cellular carbohydrate structures.
|
|
| 2. |
- Bertilsson, Emil, 1979-
(författare)
-
Skollärare : Rekrytering till utbildning och yrke 1977-2009
- 2014
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study is about the school teachers’ positions in contemporary Swedish society. In order to grasp the social characteristics of their profession and its transformations it has been important to conduct thorough analyses of the recruitment of teacher students and the recruitment to the teaching professions. The explanations to the findings are mainly based on analyses of how different kinds of assets – such as for example cultural capital and educational capital – are distributed among the students and within the school teacher corps.The data material consists of individual based statistic of all teachers 1978–2008 and all students enrolled in higher education 1977–2009, and of interviews with teachers and students. Regarding theory and methods, the study belongs to the sociological tradition founded by Pierre Bourdieu, which means that capital, strategies and social space are key concepts. The statistical techniques employed comprise mainly of different variants of correspondence analysis as well as logistic regression.As shown in the first part of the thesis an increasing share of the teacher students possess small amounts of acquired school capital, as well as weak resources inherited from their parental home. This change has been especially noticeable within the programmes educating upper secondary school teachers. In the second part, the focus is on the social positions of those upper secondary teachers. The correspondence analyses indicate a cleavage within the profession based on the teachers’ qualification and merits. Teachers richer in educational capital tend to occupy more stable professional positions and are also overrepresented at schools where the pupils feature significant educational and social assets, which in turn further contributes to the density of educational capital.One of the main results is that school teachers have been exposed to two partly opposing processes during the past decades. On the one hand, there has been increasing homogeneity, namely convergences between the employment conditions of different categories of school teachers and between different teacher education programmes. On the other hand, the social divergences within the profession tend to widen. Those gaps have increased over time because of the more differentiated school system and changes in recruitment patterns.
|
|
| 3. |
- Brinck, J., et al.
(författare)
-
Cardiovascular Outcomes in Patients With Both Diabetes and Phenotypic Familial Hypercholesterolemia: A Nationwide Register-Based Cohort Study
- 2022
-
Ingår i: Diabetes care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 45:12, s. 3040-3049
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE Patients with diabetes or familial hypercholesterolemia (FH) have an increased incidence of cardiovascular diseases compared with the population, but whether this risk is exacerbated in patients with combined traits is unknown. RESEARCH DESIGN AND METHODS In this Swedish nationwide, register-based cohort study, patients with diabetes were included between 2002 and 2020. Adjusted Cox proportional hazards models were used to assess the risk of cardiovascular events in patients with or without phenotypic FH (‡6 points for phenotypic FH according to Dutch Lipid Clinic Network criteria) compared with general population control subjects without diabetes as reference. RESULTS A total of 45,585 patients with type 1 diabetes (227,923 control subjects) and 655,250 patients with type 2 diabetes (655,250 control subjects) were followed for a median of 14.1 and 7.9 years, respectively. Of those, 153 and 7,197, respectively, had phenotypic FH. Compared with control subjects, patients with diabetes and phenotypic FH had higher risk of cardiovascular mortality (type 1: Hazard ratio 21.3 [95% CI 14.6-31.0]; type 2: 2.40 [2.19-2.63]) and of a cardiovascular event (type 1: 15.1 [11.1-20.5]; type 2: 2.73 [2.58-2.89]). Further, patients with diabetes and phenotypic FH had higher LDL-cholesterol levels during observation (P < 0.05) and increased risk of all major cardiovascular outcomes (P < 0.0001) than patients with diabetes but without FH. The proportion receiving lipid-lowering treatment was higher in patients with phenotypic FH (P < 0.0001). CONCLUSIONS Patients with both diabetes and phenotypic FH are more at risk for adverse cardiovascular outcomes and have higher LDL-cholesterol levels despite receiving intensified lipid-lowering therapy.
|
|
| 4. |
- Eberhard, Anna, et al.
(författare)
-
Radiographic damage in early rheumatoid arthritis is associated with increased disability but not with pain-a 5-year follow-up study
- 2023
-
Ingår i: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 25:1
-
Tidskriftsartikel (refereegranskat)abstract
- ObjectivesTo evaluate how radiographic damage, overall and measured as joint space narrowing score (JSNS) and erosion score (ES), as well as other clinical and laboratory measures, relate to disability and pain in early rheumatoid arthritis (RA).MethodsAn inception cohort of 233 patients with early RA, recruited in 1995-2005, was followed for 5 years. Disability was assessed with the Health Assessment Questionnaire (HAQ), and pain with a visual analogue scale (VAS; 0-100 mm). Radiographs of hands and feet were evaluated using the Sharp-van der Heijde score (SHS), including JSNS and ES. The relation for radiographic scores and other clinical parameters with pain and HAQ were evaluated cross-sectionally by multivariate linear regression analysis and over time using generalized estimating equations.ResultsES was significantly associated with HAQ cross-sectionally at inclusion, after 2 and after 5 years, and over time. Associations for HAQ with SHS and JSNS were weaker and less consistent compared with those for ES. There was no association between radiographic scores and pain at any visit. Both HAQ and pain were associated with parameters of disease activity. The strongest cross-sectional associations were found for the number of tender joints (adjusted p<0.001 at all visits).ConclusionJoint damage was associated with disability already in early RA. Erosions of hands and feet appear to have a greater influence on disability compared with joint space narrowing early in the disease. Pain was associated with other factors than joint destruction in early RA, in particular joint tenderness-suggesting an impact of pain sensitization.
|
|
| 5. |
|
|
| 6. |
- Mijwel, Sara, et al.
(författare)
-
Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy : the OptiTrain breast cancer trial.
- 2018
-
Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 169:1, s. 93-103
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Advanced therapeutic strategies are often accompanied by significant adverse effects, which warrant equally progressive countermeasures. Physical exercise has proven an effective intervention to improve physical function and reduce fatigue in patients undergoing chemotherapy. Effects of high-intensity interval training (HIIT) in this population are not well established although HIIT has proven effective in other clinical populations. The aim of the OptiTrain trial was to examine the effects of concurrent resistance and high-intensity interval training (RT-HIIT) or concurrent moderate-intensity aerobic and high-intensity interval training (AT-HIIT), to usual care (UC) on pain sensitivity and physiological outcomes in patients with breast cancer during chemotherapy.METHODS: Two hundred and forty women were randomized to 16 weeks of RT-HIIT, AT-HIIT, or UC.OUTCOMES: cardiorespiratory fitness, muscle strength, body mass, hemoglobin levels, and pressure-pain threshold.RESULTS: Pre- to post-intervention, RT-HIIT (ES = 0.41) and AT-HIIT (ES = 0.42) prevented the reduced cardiorespiratory fitness found with UC. Handgrip strength (surgery side: RT-HIIT vs. UC: ES = 0.41, RT-HIIT vs. AT-HIIT: ES = 0.28; non-surgery side: RT-HIIT vs. UC: ES = 0.35, RT-HIIT vs. AT-HIIT: ES = 0.22) and lower-limb muscle strength (RT-HIIT vs. UC: ES = 0.66, RT-HIIT vs. AT-HIIT: ES = 0.23) were significantly improved in the RT-HIIT. Increases in body mass were smaller in RT-HIIT (ES = - 0.16) and AT-HIIT (ES = - 0.16) versus UC. RT-HIIT reported higher pressure-pain thresholds than UC (trapezius: ES = 0.46, gluteus: ES = 0.53) and AT-HIIT (trapezius: ES = 0.30).CONCLUSION: Sixteen weeks of RT-HIIT significantly improved muscle strength and reduced pain sensitivity. Both exercise programs were well tolerated and were equally efficient in preventing increases in body mass and in preventing declines in cardiorespiratory fitness. These results highlight the importance of implementing a combination of resistance and high-intensity interval training during chemotherapy for women with breast cancer.
|
|
| 7. |
- Nordström, Emil, et al.
(författare)
-
Local gas heating in sooting flames by heat transfer from laser-heated particles investigated using rotational CARS and LII
- 2015
-
Ingår i: Proceedings of the Combustion Institute. - : Elsevier BV. - 1540-7489. ; 35, s. 3707-3713
-
Tidskriftsartikel (refereegranskat)abstract
- Soot particles strongly absorb radiation in the visible and infrared spectral regions, and the soot interaction with laser light during laser diagnostic interrogation leads to particle heating and often to subsequent sublimation. Consequently, laser-heated particles transfer heat to the ambient gas leading to local gas heating, a process that has received minor attention so far in the diagnostic community. In the present work, this specific local gas heating is measured in a pump-probe-type experiment. A 1064-nm laser beam heated the soot particles in an ethylene/ air diffusion flame (on a Gulder-burner) with known soot volume fraction, and a two-beam rotational coherent anti-Stokes Raman spectroscopy (CARS) setup was used to probe the local gas temperature on time scales from nanoseconds to milliseconds. The temperature of the heated particles was simultaneously probed using a two-color laser-induced incandescence (2C-LII) detection system. The results show that laser heating of soot particles from flame temperatures to sublimation temperatures leads to local gas heating of similar to 100 K at a soot volume fraction of 4 ppm, in good agreement with theoretical predictions. The implication of these results to the application of laser diagnostic techniques is briefly discussed. (C) 2014 The Combustion Institute. Published by Elsevier Inc. All rights reserved.
|
|
| 8. |
- Olofsson, Kurt, et al.
(författare)
-
Automated cutting of fiber materials for tailored drapeability
- 2012
-
Ingår i: The 5th International Swedish Production Symposium. - : Svenska ProduktionsAkademien.
-
Konferensbidrag (refereegranskat)abstract
- The aim of the current project has been to study the basic technologies needed to introduce local Point Cutting of fiber weaves (local PC) into composites manufacturing. An automated cutting machine is here used to locally increase the drapeability of standard weaves, hence easing tool loading and the automation of a production line. The two tested softwares cannot simulate draping using precut fiber weaves. Drapeability experiments can instead be used to select cutting pattern and cutting area. The used tool concept (one piece tool half, several tool parts, bag etc.) will affect the minimum size of the cutting area. Several cutting patterns have been tested including the innovative cross pattern, which works best. Micro-mechanical analysis and FE simulations show that the cured material properties can be predicted. A composite part has been successfully manufactured usinglocal PC technology.
|
|
| 9. |
|
|
| 10. |
- Persson, Carina, 1964, et al.
(författare)
-
Greening of the brown-dwarf desert EPIC 212036875b: a 51 M-J object in a 5-day orbit around an F7V star
- 2019
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 628
-
Tidskriftsartikel (refereegranskat)abstract
- Context. Although more than 2000 brown dwarfs have been detected to date, mainly from direct imaging, their characterisation is difficult due to their faintness and model-dependent results. In the case of transiting brown dwarfs, however, it is possible to make direct high-precision observations. Aims. Our aim is to investigate the nature and formation of brown dwarfs by adding a new well-characterised object, in terms of its mass, radius and bulk density, to the currently small sample of less than 20 transiting brown dwarfs. Methods. One brown dwarf candidate was found by the KESPRINT consortium when searching for exoplanets in the K2 space mission Campaign 16 field. We combined the K2 photometric data with a series of multicolour photometric observations, imaging, and radial velocity measurements to rule out false positive scenarios and to determine the fundamental properties of the system. Results. We report the discovery and characterisation of a transiting brown dwarf in a 5.17-day eccentric orbit around the slightly evolved F7V star EPIC 212036875. We find a stellar mass of 1.15 +/- 0.08 M-circle dot, a stellar radius of 1.41 +/- 0.05 R-circle dot, and an age of 5.1 +/- 0.9 Gyr. The mass and radius of the companion brown dwarf are 51 +/- 2 M-J and 0.83 +/- 0.03 R-J, respectively, corresponding to a mean density of 108(-13)(+15) g cm(-3). Conclusions. EPIC 212036875 b is a rare object that resides in the brown-dwarf desert. In the mass-density diagram for planets, brown dwarfs, and stars, we find that all giant planets and brown dwarfs follow the same trend from similar to 0.3 M-J to the turn-over to hydrogen burning stars at similar to 73 M-J. EPIC 212036875 b falls close to the theoretical model for mature H/He dominated objects in this diagram as determined by interior structure models. We argue that EPIC 212036875 b formed via gravitational disc instabilities in the outer part of the disc, followed by a quick migration. Orbital tidal circularisation may have started early in its history for a brief period when the brown dwarf's radius was larger. The lack of spin-orbit synchronisation points to a weak stellar dissipation parameter (Q(star)' greater than or similar to 10(8)), which implies a circularisation timescale of greater than or similar to 23 Gyr, or suggests an interaction between the magnetic and tidal forces of the star and the brown dwarf.
|
|
