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- Tschiderer, Lena, et al.
(författare)
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Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies
- 2023
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Ingår i: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 12:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development.Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques).Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
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- Yndal-Olsen, Naja, et al.
(författare)
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Landscapes of Hybrid Activism : ‘New Welfarism’ Revisited in the Case of the Danish ‘Turbo Chicken’ Campaign
- 2024. - 1
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Ingår i: Reimagining Species Relations : A Decade of Studying and Teaching Critical Animal Studies at Lund University - A Decade of Studying and Teaching Critical Animal Studies at Lund University. - 9789189874466 - 9789189874473 ; 1:1, s. 85-101
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Bokkapitel (refereegranskat)abstract
- This chapter explores the Danish case of a years-long campaign to phase out the “production” of the fast-growing industrial chicken breed, Ross 308. Core differences between welfarism, new welfarism, and abolitionist positions of rights and liberation are outlined - and it is investigated how activists navigate the tensions between these approaches in practice. The case makes visible a tangled terrain of hybrid activism, which is more nuanced and complex than scholarly debates on the classic “welfare-abolitionist divide” tend to reflect. Finally, the chapter suggests how academic research could contribute to a more multifaceted dialogue within activist milieus about effectiveness and social change.
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