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| 2. |
- Axaeus, Jennie, 1974-, et al.
(författare)
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Portar till språk och litteratur : CSL 2007
- 2007
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Språk och litteratur öppnar portar till nya världar. Detta var temat för 2007 års CSL-dag. I denna bok har vi samlat fjorton av bidragen som presenterades på konferensen, skrivna av forskare och studenter vid Karlstads universitet.Håller engelskan på att förstöra svenskan? Är dagens elever sämre på att skriva än ungdomarna var för tjugo år sedan? Skall vi ha en litteraturkanon i skolan - och läser eleverna över huvud taget böcker nu för tiden? Detta är några av de frågor som ställs i artiklarna där svaren kanske kan överraska.Andra artiklar handlar om hur man stimulerar elever till att läsa och skriva, problematiken när det gäller att undervisa i svenska som andraspråk och varför elever väljer - eller inte väljer - att studera något annat främmande språk än engelska. Porten kanske finns där - men den är inte alltid helt lätt att öppna!
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| 3. |
- de Peppo, Giuseppe Maria, 1981, et al.
(författare)
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Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
- 2014
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Ingår i: International journal of nanomedicine. - : Informa UK Limited. - 1176-9114 .- 1178-2013. ; 9:1, s. 2499-2515
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.
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| 4. |
- Papakokkinou, Eleni, et al.
(författare)
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Excess Morbidity Persists in Patients With Cushing’s Disease During Long-term Remission : A Swedish Nationwide Study
- 2020
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - Washington : Oxford University Press. - 0021-972X .- 1945-7197. ; 105:8, s. 2616-2624
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Tidskriftsartikel (refereegranskat)abstract
- Context: Whether multisystem morbidity in Cushing's disease (CD) remains elevated during long-term remission is still undetermined.Objective: To investigate comorbidities in patients with CD.Design, setting, and patients: A retrospective, nationwide study of patients with CD identified in the Swedish National Patient Register between 1987 and 2013. Individual medical records were reviewed to verify diagnosis and remission status.Main outcomes: Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated by using the Swedish general population as reference. Comorbidities were investigated during three different time periods: (i) during the 3 years before diagnosis, (ii) from diagnosis to 1 year after remission, and (iii) during long-term remission.Results: We included 502 patients with confirmed CD, of whom 419 were in remission for a median of 10 (interquartile range 4 to 21) years. SIRs (95% CI) for myocardial infarction (4.4; 1.2 to 11.4), fractures (4.9; 2.7 to 8.3), and deep vein thrombosis (13.8; 3.8 to 35.3) were increased during the 3-year period before diagnosis. From diagnosis until 1 year after remission, SIRs (95% CI were increased for thromboembolism (18.3; 7.9 to 36.0), stroke (4.9; 1.3 to 12.5), and sepsis (13.6; 3.7 to 34.8). SIRs for thromboembolism (4.9; 2.6 to 8.4), stroke (3.1; 1.8 to 4.9), and sepsis (6.0; 3.1 to 10.6) remained increased during long-term remission.Conclusion: Patients with CD have an increased incidence of stroke, thromboembolism, and sepsis even after remission, emphasizing the importance of early identification and management of risk factors for these comorbidities during long-term follow-up.
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| 5. |
- Ragnarsson, Oskar, 1971, et al.
(författare)
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Overall and Disease-Specific Mortality in Patients With Cushing Disease: A Swedish Nationwide Study
- 2019
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : ENDOCRINE SOC. - 0021-972X .- 1945-7197. ; 104:6, s. 2375-2384
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Tidskriftsartikel (refereegranskat)abstract
- Context: Whether patients with Cushing disease (CD) in remission have increased mortality is still debatable. Objective: To study overall and disease-specific mortality and predictive factors in an unselected nationwide cohort of patients with CD. Design, Patients, and Methods: A retrospective study of patients diagnosed with CD, identified in the Swedish National Patient Registry between 1987 and 2013. Medical records were systematically reviewed to verify the diagnosis. Standardized mortality ratios (SMRs) with 95% CIs were calculated and Cox regression models were used to identify predictors of mortality. Results: Of 502 identified patients with CD (n = 387 women; 77%), 419 (83%) were confirmed to be in remission. Mean age at diagnosis was 43 (SD, 16) years and median follow-up was 13 (interquartile range, 6 to 23) years. The observed number of deaths was 133 vs 54 expected, resulting in an overall SMR of 2.5 (95% CI, 2.1 to 2.9). The commonest cause of death was cardiovascular diseases (SMR, 3.3; 95% CI, 2.6 to 4.3). Excess mortality was also found associated with infections and suicide. For patients in remission, the SMR was 1.9 (95% CI, 1.5 to 2.3); bilateral adrenalectomy and glucocorticoid replacement therapy were independently associated with increased mortality, whereas GH replacement was associated with improved outcome. Conclusion: Findings from this large nationwide study indicate that patients with CD have excess mortality. The findings illustrate the importance of achieving remission and continued active surveillance, along with adequate hormone replacement and evaluation of cardiovascular risk and mental health.
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| 6. |
- Ragnarsson, Oskar, 1971, et al.
(författare)
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The incidence of Cushing’s disease : a nationwide Swedish study
- 2019
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Ingår i: Pituitary. - : Springer. - 1386-341X .- 1573-7403. ; 22:2, s. 179-186
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden.Methods: Patients registered with a diagnostic code for Cushing’s syndrome (CS) or CD, between 1987 and 2013 were identified in the Swedish National Patient Registry. The CD diagnosis was validated by reviewing clinical, biochemical, imaging, and histopathological data.Results: Of 1317 patients identified, 534 (41%) had confirmed CD. One-hundred-and-fifty-six (12%) patients had other forms of CS, 41 (3%) had probable but unconfirmed CD, and 334 (25%) had diagnoses unrelated to CS. The mean (95% confidence interval) annual incidence between 1987 and 2013 of confirmed CD was 1.6 (1.4–1.8) cases per million. 1987–1995, 1996–2004, and 2005–2013, the mean annual incidence was 1.5 (1.1–1.8), 1.4 (1.0–1.7) and 2.0 (1.7–2.3) cases per million, respectively. During the last time period the incidence was higher than during the first and second time periods (P < 0.05).Conclusion: The incidence of CD in Sweden (1.6 cases per million) is in agreement with most previous reports. A higher incidence between 2005 and 2013 compared to 1987–2004 was noticed. Whether this reflects a truly increased incidence of the disease, or simply an increased awareness, earlier recognition, and earlier diagnosis can, however, not be answered. This study also illustrates the importance of validation of the diagnosis of CD in epidemiological research.
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| 7. |
- Brunosson, Albina, 1986-, et al.
(författare)
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Aspects of cooking in food and meal science
- 2013
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Ingår i: 8th International Conference on Culinary Arts and Sciences. - 9789898631084 ; , s. 206-210
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Konferensbidrag (refereegranskat)abstract
- Education and research within the interdisciplinary subject food and meal science can be mediated through science, craft and creativity and cooking is a central activity. This paper aims at elucidating some aspects of cooking through the perspectives “Culture and Communication” “Food Science” and “Nutrition and Health”. This was done through a survey among students and teachers. The results stress the importance of an interdisciplinary approach to understand the different aspects of cooking and the prominent view on cooking as a cultural and communicative activity.
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| 8. |
- Igelström, Helena, 1976-, et al.
(författare)
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Long-term effects on depression and anxiety of an internet-based stepped care intervention for patients with cancer and symptoms of depression and anxiety : The U-CARE AdultCan trial
- 2023
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Ingår i: Internet Interventions. - : Elsevier. - 2214-7829. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cancer is a serious disease that commonly causes significant psychological distress. The internet-based intervention (iCAN-DO), utilizing a stepped care approach for the treatment of anxiety and depression in individuals with cancer, has been shown to have favorable results for symptoms of depression at the primary endpoint, 10 months after randomization compared to standard care (SC). The aim of the present study was to evaluate the long-term effects of the intervention 18 and 24 months after randomization.METHODS: Patients with breast, colorectal, or prostate cancer and a score > 7 on either of the Hospital Anxiety and Depression Scale (HADS) subscales (n = 245) were recruited to the study in conjunction with a regular hospital visit. They were randomized to access to the stepwise iCAN-DO intervention for 24 months or to SC. Step 1 of the intervention comprised psycho-educative online material. In Step 2, internet-based cognitive-behavioral therapy with individual online support from a therapist was added. Step 2 was offered to those who reported persistent anxiety or depression symptoms (>7 on HADS), also at 1, 4, and/or 7 months after randomization. Missing data were imputed using the last rank carried forward method and used for the main analyses according to the intention-to-treat approach. Effects sizes (Cohen's d), and minimally clinically important difference (MCID) were calculated. Linear mixed models were used to analyze intervention effects over time.RESULTS: Symptoms of depression decreased significantly (p < 0.05) in the iCAN-DO group compared with the SC group from baseline to 18 months (d = 0.29), but not to 24 months (d = 0.27). Even though the average iCAN-DO group participant surpassed a MCID in symptoms of anxiety (>2 p) at both long-term follow-ups, the differences did not reach statistical significance, either at 18 months (p = 0.10) or 24 months (p = 0.09). Positive effects of iCAN-DO compared with the SC were also shown for some secondary HRQoL-outcomes; social functioning at 18 months (p = 0.02) and 24 months (p = 0.001), and sleep problems at 24 months (p = 0.01).CONCLUSION: A stepped-care internet-based intervention that has previously shown positive results for symptoms of depression at 10 months did show similar positive long-term effects also at 18 months. For symptoms of anxiety, no effect could be shown. The internet may provide an effective format for interventions to reduce symptoms of depression after cancer at patients' own choice of time, regardless of distance to a psycho-oncology clinic.
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| 9. |
- Johansson, Kristin, 1979, et al.
(författare)
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Environmental impact of the EPSPEX system. Part 1: Life cycle assessment of polystyrene insulated district heating systems with PEX fluid pipes
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The EPSPEX system is a distribution system for district heat with media pipes of cross-linked polyethylene (PEX) insulated by blocks of expanded polystyrene (EPS). In this low-pressure distribution system two pipes are used for a space heating circuit, having layers of EVAL to hinder oxygen diffusion, whereas two pipes without diffusion barrier are used for delivery of hot tap water and warm water circulation. The four pipes are placed in the insulating blocks of EPS. Environmental impacts from production, laying and use of an EPSPEX district heat distribution system have been investigated using life cycle methodology. The distribution system is a secondary system developed specially for areas with low heat density. The case studied is the installation and use of an EPSPEX system in Vråen, Värnamo, Sweden. The environmental impacts are described in four categories:climate change, acidification, eutrophication and use of finite resources. Four weighting methods have also been used in the evaluation: EPS2000, Ecoscarcity, ExternE and EcoIndicator99. While carefully considering the precise circumstances of this study, the findings can be adapted for using the EPSPEX district heat distribution systems in other areas.During this study the question was raised of how this district heat delivery system compares with systems that use conventional district heating pipes. This has beenfurther investigated and is reported in the second part of this report: Miljöbelastning från EPSPEX-systemet. Del 2: Konventionella twinrör eller EPSPEX vad är bäst urmiljösynpunkt. In the second part the environmental impacts from the EPSPEX system have been compared with the impacts from conventional twin pipes (polyurethane insulated steel media pipes) used in a comparable setting. A discussion on the environmental choice between media pipes of PEX and steel can also be found in the second part. It should be noted that the two systems for district heat distribution are not fully comparable in function. The EPSPEX system has stricter limitations regarding pressure and temperature compared with the conventional system. The EPSPEX system is also limited in use for well drained ground conditions above the water table. Conventional district heating pipes do not have this limitation. The most important possibility to decrease the environmental impacts from the EPSPEX system is to increase the insulation, this even though the distribution systemis comparably well insulated to start with. The environmental life cycle impacts of the distribution pipe system production, laying and use are predominated by the extra heat that has to be generated to cover the heat losses from the system. When this report was written, measurements from systems in use to confirm the model calculation of heat losses are still lacking. More fine-tuned results can be achieved when studies of the EPSPEX system in use have been concluded.Among different components in the EPSPEX system the impacts from production and transport of EPS-blocks make the major impact. Thus, it is important to utilize the polystyrene material as efficiently as possible, minimizing spillage, and to ensure that unavoidable spillage is recycled as material. However, the environmental impacts from production of the insulating blocks are well outweighed by the decreased environmental impacts gained by using the insulation. In product development it is thus important to ensure that the insulating capacity of the EPSPEX system is never decreased.Machines used for excavating the pipe trenches combust diesel oil, and the production and use of this diesel oil generates a substantial part of the environmental impacts byseveral of the assessment methods used. If possible, it is desirable to further minimize the excavation work and to use mini excavators and low emitting machines (especially regarding nitrous oxides). The brass swaged coupling used to connect the PEX-pipes, gives a strong impact regarding acidification and the two weighting methods EPS2000 and Ecoscarcity, especially when compared to the very small volume fraction these devices constitute. It would be advisable to study if the devices could be made from other material or from recycled material.
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| 10. |
- Johansson, Kristin, 1979, et al.
(författare)
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Environmental impact of the EPSPEX system. Part 2: Traditional twin pipes or EPSPEX for district heat distribution - what is best from an environmental point of view?
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this study the life-cycle environmental impacts from an EPSPEX system for distribution of district heat (a four-pipe system with centrally generated hot tap water) are compared with the environmental impacts of a twin-pipe system with steel media pipes, if installed in the same area. A life cycle assessment of the EPSPEX system constructed in Vråen, Värnamo, Sweden, has been reported in Miljöbelastning från EPSPEX-systemet. Del 1: Livscykelanalys av polystyrenisolerat fjärrvärmesystemmed PEX-mediarör [1]. In that study the question was raised of how the EPSPEX system compares with a conventional twin-pipe system with polyurethane-insulated steel media pipes.In the present study the EPSPEX system in Vråen is compared with a hypothetical construction of a conventional twin pipe system in the same area. Two different fuel mixes for district heat generation have been studied to increase the understanding of the environmental performance of district heat distribution systems; the fuel mix used in Vråen (heat delivered from Värnamo Energi) and Swedish average district heat. How media pipes from the two different materials (PEX and steel) compare is discussed in a separate part. There are technical differences that must be kept in mind when the systems are compared in this way. The EPSPEX system is designed for low-pressure district heat systems and could only be used in such context. It is unadvisable to install the EPSPEX system below the ground water table; this is not a restriction for the twin pipe system. Under the conditions of this study the environmental performance of the EPSPEX system is better than the twin pipe system.The heat loss from the EPSPEX system is approximately 60% of the heat loss for a comparable twin pipe system. This is caused by a combination of thick insulation for the EPSPEX system and the possibility to summertime shut down the district heating circuit for this system and only use the hot tap-water circuit. Note, however, that the heat loss from the EPSPEX system is more uncertain compared to the twin-pipe system. From the characterization methods used, the production of the EPSPEX system gives a higher environmental impact compared to the twin pipe system. This heavily depends on the large amount of insulating material used. However, the environmental impacts from production of the insulation are more then outweighed by the emissionsavoided from heat generation due to lower heat loss. District heating sub centrals generates a notable part of the total environmental impact when using the weighing method EPS2000. Note that sub centrals are not technicallynecessary in low-pressure district heat systems, as the EPSPEX system. The comparison between different fuel mixes for heat generation indicates clearly that the heat generation is an important parameter for environmental performance for all district heating. It is further indicated that also biofuels must be used with sensible andenvironmentally friendly methods. The media pipes of PEX seem to give lower environmental impacts compared withmedia pipes of steel. However, the results differ between assessment methods used.
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