| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Emaus, Marleen J., et al.
(författare)
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Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study
- 2014
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 135:12, s. 2887-2899
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Tidskriftsartikel (refereegranskat)abstract
- Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.
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| 3. |
- Arlien-Soborg, Mai C., et al.
(författare)
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Acromegaly management in the Nordic countries: A Delphi consensus survey
- 2024
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Ingår i: Clinical Endocrinology. - : WILEY. - 0300-0664 .- 1365-2265.
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
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| 4. |
- Arlien-Søborg, Mai C., et al.
(författare)
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Acromegaly management in the nordic countries : a Delphi consensus survey
- 2024
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Ingår i: Clinical Endocrinology. - : John Wiley & Sons. - 0300-0664 .- 1365-2265.
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale.Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
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| 5. |
- Arvidsson, Ida, et al.
(författare)
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Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome.
- 2015
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 194:5, s. 2309-2318
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Tidskriftsartikel (refereegranskat)abstract
- Shiga toxin (Stx)-producing Escherichia coli (STEC) cause hemolytic uremic syndrome (HUS). This study investigated whether Stx2 induces hemolysis and whether complement is involved in the hemolytic process. RBCs and/or RBC-derived microvesicles from patients with STEC-HUS (n = 25) were investigated for the presence of C3 and C9 by flow cytometry. Patients exhibited increased C3 deposition on RBCs compared with controls (p < 0.001), as well as high levels of C3- and C9-bearing RBC-derived microvesicles during the acute phase, which decreased after recovery. Stx2 bound to P1 (k) and P2 (k) phenotype RBCs, expressing high levels of the P(k) Ag (globotriaosylceramide), the known Stx receptor. Stx2 induced the release of hemoglobin and lactate dehydrogenase in whole blood, indicating hemolysis. Stx2-induced hemolysis was not demonstrated in the absence of plasma and was inhibited by heat inactivation, as well as by the terminal complement pathway Ab eculizumab, the purinergic P2 receptor antagonist suramin, and EDTA. In the presence of whole blood or plasma/serum, Stx2 induced the release of RBC-derived microvesicles coated with C5b-9, a process that was inhibited by EDTA, in the absence of factor B, and by purinergic P2 receptor antagonists. Thus, complement-coated RBC-derived microvesicles are elevated in HUS patients and induced in vitro by incubation of RBCs with Stx2, which also induced hemolysis. The role of complement in Stx2-mediated hemolysis was demonstrated by its occurrence only in the presence of plasma and its abrogation by heat inactivation, EDTA, and eculizumab. Complement activation on RBCs could play a role in the hemolytic process occurring during STEC-HUS.
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| 6. |
- Bodin, Lina, et al.
(författare)
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The amount of straw for growing-finishing pigs considering the reduction of time spent in manipulative behavior
- 2015
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Ingår i: SOJ Veterinary Sciences. - 2381-2907. ; 1
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Tidskriftsartikel (refereegranskat)abstract
- The behavior of rooting and digging is highly motivated in the pig. The motivation to perform this exploratory behavior is not reduced even after the dietary requirement has been fulfilled through feeding. The aim of this study was to identify the minimal amounts of straw needed to satisfy pig motivation for manipulation and reduce to a minimum the manipulating behavior of pigs directed toward pen mates. To determine the minimal amount of straw needed for conventional growing-finishing pigs, a study using 168 pigs provided with 7 different amounts of straw (20, 40, 60, 80, 100, 200 or 300 grams/ pig/ day) was performed. The straw was provided either once or four times per day. Behavior observations were made using focal animal sampling and continuous recording for one hour between 9 and 10 am and between 3 and 4 pm. The time spent by the pigs manipulating straw increased over 10% ranging up to 27% in all the pens receiving over 200g of straw per day compared to the range from 4-22% in pens receiving 20-100g of straw. Meanwhile, the time spent in redirected behavior decreased below 5% in all the pens receiving over 200g of straw per day. No significant differences were found when comparing pens provided with straw once or four times per day.
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| 7. |
- Botermans, Jos, et al.
(författare)
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Comparison between air inlet via channels under the building and air inlets via the ceiling for growing-finishing pigs
- 2014
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the studies was to compare the indoor climate between two different ventilation systems for growing-finishing pigs. In one housing system the air came into the pig house via channels under the lying area of the pigs. The air came into the compartment close to the lying area of the pigs. The first part of the exhaust air was via another channel along the manure channel (pit ventilation). The rest of the exhaust air was via two fans in the ceiling (farm 1). In the other housing system the air came into the pig house via air inlets in the ceiling. The exhaust air was via two fans in the ceiling (farm 2). Measurements were done during one summer batch and one winter batch. Air temperature was measured for 5-8 weeks with mini-loggers. Ammonia concentration, carbon dioxide concentration, air speed and differences in air pressure between in and outside the pig house, were registered at 4 occasions. During summer time, the temperature of incoming air via the channels under the building (farm 1) was almost the same as the temperature of the air outside. So the cooling effect in the channels was very small. However, on the farm with air inlets in the ceiling (farm 2), the incoming air, during the afternoon, was about 3 0C above the temperature outside. So during the warmest period of the day, the air was heated on the ceiling. On the farm with channels under the lying area, the pigs continued to lie on the concrete lying area instead of the slatted flooring and the cleanliness of the pens was good (farm 1). During winter time, the temperature of the incoming air via the channels under the building was about 4 0C above the air temperature outside. On the farm with air inlets in the ceiling, the air temperature of the incoming air was the same as the temperature of the air outside.
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| 8. |
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| 9. |
- Botermans, Jos, et al.
(författare)
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Olika mängder halm till slaktgrisar
- 2014
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Ingår i: LTV-fakultetens faktablad.
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Annan publikation (populärvet., debatt m.m.)abstract
- Halm har tydliga positiva effekter för slaktgrisars välbefinnande. Informationen, om vilken mängd av halm som krävs för att uppnå dessa positiva effekter, är dock bristfällig. Målsättningen med det utförda projektet var att få fram underlag kring vilka halmmängder som bör ges till slaktgrisar i konventionella inhysningssystem. Totalt ingick tre slaktgrisomgångar med 14 boxar per omgång. Sju olika halmmängder (20, 40, 60, 80, 100, 200 och 300 gram/slaktgris/dag), som tilldelades som en (kl. 10.00) alternativt fyra givor (kl. 10.00, 12.00, 14.00 och 16.00), jämfördes. Grisar som fick 200 eller 300 gram halm/gris/dag spenderade mer tid med att manipulera halm än de grisar som fick 20-100 gram halm/gris/dag. Grisar som fick 20 - 100 gram halm/gris/dag visade mer omriktat beteende än grisar som fick 200 eller 300 gram halm/gris/dag. "Gränsgivan", då man minskar de negativa beteendena, tycktes i denna studie ligga vid mellan 100 och 200 gram halm/gris/dag. Vid högre halmgivor registrerades inga extra fördelar avseende de negativa beteendena medan förekomsten av undersökande beteenden ökade. Vid små halmgivor visade de grisar, som fick sin halm uppdelad på fyra tillfällen, mer omriktat beteende än grisar som fick samma mängd vid bara ett tillfälle. Slutsatsen av studien är att mängden halm bör ligga mellan 100 - 200 gram/gris/dag om man enbart tar hänsyn till negativa beteenden hos grisen, men minst 300 g om man tar hänsyn till grisens behov av att undersöka sin omgivning.
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| 10. |
- Botermans, Jos, et al.
(författare)
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Performance, health and behaviour of organic growing-finishing pigs in two different housing systems with or without access to pasture
- 2015
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Ingår i: Acta Agriculturae Scandinavica, Section A - Animal Science. - : Informa UK Limited. - 0906-4702 .- 1651-1972. ; 65, s. 158-167
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Tidskriftsartikel (refereegranskat)abstract
- The effects of two housing systems (deep litter and straw-flow), with and without access to pasture during the summer period, were studied in an organic growing-finishing pig herd. Performance, health, skin lesions and daytime pig activity were studied in 29 pens of 16 pigs (total of 464 pigs, in 4 batches). Data from 21 pens were used for comparisons of deep litter and straw-flow and data from 16 pens for comparisons of access/no access to pasture. Pigs in the deep litter system had a lower carcass meat percentage (56.6% vs. 57.3%) and more locomotion problems (4.4% vs. 0%) than pigs in the straw-flow system. No difference in daytime pig activity was detected between the two housing systems. Under moderate temperatures, pigs with access to pasture and fed a commercial organic feed inside the building were not more active during daytime behaviour studies (7.30 h-16.30 h) than pigs without access to pasture. However, at 17 weeks of age the pigs with pasture access spent 21% of their time on pasture, less time inside the pig house (20% vs. 33%) and less time on the outside concrete area (4% vs. 12%) than the pigs without pasture. No difference in performance was detected between pigs with and pigs without access to pasture.
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