| 1. |
- Hellberg, Sandra, 1986-
(författare)
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Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple Sclerosis
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement.The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment.The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells.This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.
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| 2. |
- Eriksson [Engvall], Gunilla, 1976-
(författare)
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The intelligence discourse : the Swedish military intelligence (MUST) as a producer of knowledge
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish Military Intelligence and Security Directorate (MUST) is a producer of knowledge, a knowledge that is fundamental for decisionmaking in foreign and security policy. The intelligence knowledge production is often held as objective, value neutral, and with the intention of ‘speaking truth onto power’. However, this study holds that such a perspective on intelligence knowledge production calls for a revision. Hence, the overall purpose of this study is to examine the characteristics of knowledge in intelligence analysis and also to investigate how that knowledge is affected by the social context of its production, the military intelligence service. The source material is of three kinds; first texts and documents, second interviews with intelligence analysts and managers, and third observations of seminars and meetings during the production process of estimates.The results are that there is a strong presence of an implicit interpretive framework that continuously influences and guides the knowledge production and thereby makes the knowledge dependent on one specific perspective contrary to the intentional objectivity within the intelligence service. Further, the study reveals that the social and discursive practices for intelligence knowledge production include a ‘logic of appropriateness’ suggesting the presence of a structured Denkkollektiv with a structured Denkstil. The actions and choices of the individuals are transformed to create conformity to the norms within the social discursive practices. Thus, the inherited frame of interpretation, as well as the socialised norm of staying within the existing accepted frames ofthinking and acting ends up to the stability and duration of the not always accurate and fruitful Denkstil.At the core of political science resides the question of how policy is shaped. Even though this study has focused merely on one organisation in a specific policy field in one country it brings insights to the knowledge and policy nexus.
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| 3. |
- Harkema, Gert Jan, 1986-
(författare)
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Aesthetic Experiences of Presence : Case Studies in Film Exhibition, 1896-1898
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study investigates viewing experiences that came with the introduction of cinema. Merging (film) history with aesthetic theory, this dissertation entails historically informed theoretical reconstructions of viewing experiences between 1896 and 1898. During this novelty period, projected moving pictures evoked a wide array of reactions: on the one hand, early cinema was an extraordinary and astonishing attraction while, on the other hand, it was deeply rooted in daily life and everyday perception. To contemporary audiences, early moving pictures presented an unevenness hovering between amazement and contemplation. This study argues that the cinematograph, the vitascope, and other animated-picture attractions were popular at this early stage because they immediately appealed to the senses. These sensations are subsequently discussed as effects of presence. Early moving-picture exhibitions, moreover, can be seen as performances involving spectators in a play with presence vis-à-vis absence. While moving-picture attractions had an immediate impact on the viewer’s body as situated in the “here and now” of the auditorium, the pictures presented places and objects that were irrevocably inaccessible and absent. Exploring different viewing situations in two different contexts, the current study therefore proposes the aesthetic experience of presence as a framework to understand these various late 19th-century viewing experiences.The three chapters of this dissertation are organized separately around the concepts of intermediality, movement, and space. Chapter 1 proposes that, in the context of fairgrounds in the Netherlands, early cinema’s “intermedial enmeshing” is a probable cause for the aesthetic experience of presence. This chapter employs the concept of intermediality to outline how the kinematograph attraction caused both a semantically rich as well as a sensuously multivalent experience. It then presents a detailed study of the activities and attractions of the showman Henri Grünkorn before he exhibited “Electric Cinematograph.” Chapter 1 also investigates the various layers of discourse involved in Aladin ou la lampe merveilleuse (1897), a series of scenes exhibited by Grünkorn that was popular with local audiences at the time.Chapter 2 focuses on the experience of movement. Through a close study of the introduction of moving images in the context of Chicago in 1896 and 1897, it proposes that moving pictures presented a radically familiar form of motion. It was familiar in the sense that it brought together a number of constellations of motion and energy fundamental to modernity. Situating moving images in the rhythms of the city allows us to conceptualize the spectator as physically engaged with the motion of the kinematograph. Chapter 3 studies the paradox of proximity and distance and discusses moving-picture attractions as they were introduced in vaudeville and popular theater in Chicago. It describes the different constellations between screen and live performance from a spatial perspective while focusing on the representation of bodies. In many ways, the paradox of nearness and distance allowed for a spatially oriented play with presences. The study concludes with a discussion on the potential and challenges of including presence effects in film-historical research on viewing experiences in early cinema and beyond.
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| 4. |
- Persson, Monika, 1979-
(författare)
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The dynamics of policy formation : making sense of feelings of public unsafety
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Every policy problem has inherent value dimensions. It is on the basis of values that a state of affairs is perceived as undesirable, and thus acknowledged as a problem. This makes the process of defining and negotiating the meaning of a problem an essentially political process. Despite this, bureaucracy and expertise have a strong, if not increasing, influence over the formation of policy problems. An objectivist knowledge view predominates within the public managerial realm, which obscures the political dimension of problem formulation, while policy problems tend to be approached as a matter of efficiency.This thesis provides an account of mechanisms that shape and constrain the way a particular policy problem is understood and addressed. It analyses how policy actors make sense of particular problems, by drawing on different discourses (scientific, institutional, popular or media). The empirical case of this thesis is the formation of public safety policy in Sweden. The understanding of the problem of unsafety within Swedish policy is shown to be intrinsically related to the research field of fear of crime. The two are mutually dependent and exert an ideational path dependency. The ideational constraints on the understanding of unsafety are further affected by the institutional setting. It is argued that the appointed institutions and the emphasis on local level have a part in fostering individualist explanations and solutions,while obviating structural interpretations of the problem.The thesis finds that when governing complex policy problems there is a need to pay closer attention to how the problem is defined and how its meaning is constrained. It is crucial to make transparent the values inherent in definitions of problems as well as in research claims. By acknowledging the entwinement of policy and research the policy formation process may become characterized by greater reflexivity, and the possibility of resolving wicked problems may enlarge.
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| 5. |
- Cocos, Marta, 1988-
(författare)
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Hybrid Research Policy : How to Organize Research Funding
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Science and innovation are crucial parts of societal prosperity. Yet managing scientific activities is challenging because, even before the implementation of any give n policy starts, policy makers have to overcome the fact that there areprofoundly different views on what the role of science in society should be and hence how the state could intervene to shape or increase the research outputs. There are those who believe that the key role of science is to bring unforeseen discoveries through curiosity-driven research endeavors, while others believe that research should addresses societal challenges, like economic growth. Given these multitude of sometimes conflicting demands, and the multitude of policy actors embracing different demands, the research funding system tends to become fragmented. This phenomenon has been defined in scientific literature as institutional hybridization. However, as much as hybridization might be a pragmatic solution to addressing rising policy demands, it carries numbers of difficulties in designing the funding system and securing efficient implementation. Deeper understanding of institutional hybridity in research policy could help us avoid some of the existing problems and contribute to better informed design of research funding policy.This dissertation taps into the core of tensions that shape the way we fund science in Europe. It aims to provide a better understanding of how different expectations and requirements on research outputs are handled through the organization and implementation of public research funding. The first contribution of this dissertation is the elaboration of institutional logics shaping research funding policy: academic excellence, research utility, and funding efficiency logic. Another contribution of the thesis is better understanding of how the three logics are expressed in practice via different types of research funding efforts, as well as how they are then combined into a multi-level hybridity of research funding systems in Europe. The third contribution is the examination of the process of handling of tensions created by clash of institutional logics, providing an in-depth empirical insight into case of Swedish research policy.
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| 6. |
- Gustafsson, Tommy, 1969-
(författare)
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En fiende till civilisationen : manlighet, genusrelationer, sexualitet och rasstereotyper i svensk filmkultur under 1920-talet
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The setting for this study is Swedish film culture of the 1920s, which has been studied with a focus on representations of masculinity and gender relations according to four themes: 1) children and youth 2) fatherhood and love 3) sexuality and popularity 4) ethnicity and racial stereotyping. The rise of new consumer culture in the first decades of the 20th century created turmoil between traditional and modern values, not least when it came to conceptions of gender. Studies on masculinity have often directed its efforts towards writing a history of ideals, bound by the concept of hegemonic masculinity; a concept that exclude women as insignificant for the social construction of masculinity. One ambition with this thesis has been to counter the long-lasting concept of hegemonic masculinity, and in the process, try to build a bridge between men and women studies. One other ambition has been question the canonisation of the “Golden Age” of Swedish silent filmmaking by introducing the concept of “the pluralism of film”, and by using a vast material including: Swedish feature films, reviews, articles from fan magazines and trade paper, screen plays, censorship cards, official reports, etc; thereby circumventing the concept of film as “art” in order to focus on film as representation in a more reliably way. One conclusion is the revelation of the diversity that surrounds social constructions of masculinity and gender relations in both film culture and society. In addition, Swedish film of the 20s hardly contained any male characters that upheld the hegemonic ideal, giving way to a more prominent presence of strong female characters, often in the shape of the New Woman. Women did as well have a great influence on the formation of masculinity. However, a notion of a Swedish normative masculinity became visible when contrasted with numerous racial stereotypes, such as malicious representations of Black people and Travellers. The emphasis on gender relations, rather than on ideals, has also contributed to a wider understanding of gender, where criteria such as generation, class, ethnicity and sexuality ought to be included. When it comes to the canonisation of the “Golden Age”, a strong notion exists about the integrated use of nature in film narratives as being a Swedish national trait, when in fact this could be linked only to a few films. If one would point out a trait that permeates Swedish film of the 1920s, it would not be the use of nature, but instead the flagrant racism and xenophobia.
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| 7. |
- Oscarsson, Jan, 1958-
(författare)
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Strength grading of structural timber and EWP laminations of Norway spruce : Development potentials and industrial applications
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Machine strength grading of structural timber is a sawmill process by which considerable value is added to sawn products. The principle of such grading is that the strength of a timber member is predicted on the basis of a so called indicating property (IP) which, in general, represents an averaged value of the modulus of elasticity (MOE) measured over a board length of about one meter or more.A limitation of today’s grading methods is that the accuracy of strength predictions is often rather poor, which results in a low degree of utilization as regards structural potential of sawn timber. However, it has for many years been well known to researchers that much better strength predictions can be made by using localized MOE values, determined over a very short length, as IP. Still, the determination of such values in a sawmill production environment has been technically very difficult to achieve.In the research presented in this thesis, dot laser scanning with high resolution was utilized for detection of local fibre orientation on the surfaces of timber members. Since wood is an orthotropic material with superior structural performance in the longitudinal fibre direction, information about fibre orientation was, in combination with beam theory and measured wood material properties, used to determine the bending MOE variation along boards. By application of an IP defined as the lowest MOE found along a board, more accurate strength predictions than what is obtained by common commercial grading techniques was attained.The thesis also involves flatwise wet gluing of Norway spruce side boards into laminated beams. As side boards, being cut from the outer parts of a log, have excellent structural properties it was not surprising to find that the beams had high strength and stiffness, even when laminations of sawfalling quality were used. The possibility of grading boards in a wet state by means of axial dynamic excitation was investigated with a positive result and application of simple grading rules resulted in considerable improvement of beam bending strength. Finally, bending MOE variation determined on the basis of laser scanned fibre directions was used for identification of weak sections in laminations. Elimination of such sections by means of finger jointing showed that average lamination strength of a board sample could be improved by more than 35 percent.
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| 8. |
- Adenskog, Magnus, 1985-
(författare)
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Democratic innovations in political systems : towards a systemic approach
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There are many indicators that the representative democratic system is currently facing serious legitimacy challenges. Two central indicators of these challenges are changing patterns of political participation and a decline in system support. Against this backdrop, a growing number of governments claim that democratic innovations (DIs) could reconnect institutions with citizens. This thesis focuses on online DIs implemented in real political contexts, and the overarching aim of the thesis is to contribute to the emergent empirical scholarship on how DIs can influence political systems. In the last two decades, most empirical studies in the field have analysed DIs at the micro level.This thesis takes a different stance by posing system-related research questions to the implementation of DIs and, by doing so, showing how DIs are interrelated with, rather than isolated from, the political system and that DIs can influence political systems. The thesis consists of one literature review and three empirical case studies, applying a multiple methodological approach. Its novelty lies in three main empirical findings that contribute to the development of the field. First, it shows that participation in DIs can influence citizens’ perceived trust towards local political institutions. In addition, the results suggest that predispositions and prior engagement mediate the direction of change in trust amongst citizens. Secondly, the results show that DIs can perform different political functions, such as facilitating spaces for citizens to provide original ideas and deliberation, while also having an agenda-setting function. Thirdly, the result suggest that long-term institutional change is complex and that the implementation of DIs can create a situation in which civil servants and politicians perceive their organisation to be in some ‘state of flux’, as they are torn between two competing institutional logics. In conclusion, this thesis should be understood as a piece in a broader movement that works towards a systemic approach to the study of DIs, and that by showing these empirical findings, the thesis contributes to deepening our understanding of what influences and functions DIs can have in political systems.
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| 9. |
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| 10. |
- Bachmann, Anne, 1976-
(författare)
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Locating Inter-Scandinavian Silent Film Culture : Connections, Contentions, Configurations
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis revisits film and film-culture history in Sweden, Denmark and Norway with a view to discourses and practices of the inter- and trans-Scandinavian in the silent era. Excluding the earliest films, but including the transition to synchronised sound, it covers the period of the 1900s to 1930 with emphasis on the 1910s and 1920s. The thesis identifies notions about the relations between the Scandinavian and the national by means of a number of case studies based on textual historical sources. As a consistent Scandinavian perspective on this period is new, the investigation substantially supplements and revises the individual national film histories of these countries. It adds missing context to national developments and makes visible border phenomena such as transnational collaborations and co-producing practices.The thesis finds that film production in Scandinavia in the silent era was orientated towards one of two poles, at times combined or in a state of negotiation: international economic ambitions or national cultural aspirations. The latter was frequently conceptualised as northern, Nordic and Scandinavian. ‘Scandinaviannesses’ performed when drawing on nature, folklore, literature and heritage, not least that of Norway, were employed for use in and out of Scandinavia by means of strategies of ‘double-entry book-keeping’. During the period, the notion of location underwent changes from an illusory, theatrical device to an inherently meaningful entity carrying identities infused with the Scandinavian. Examining the effects of shared comprehension of language and a shared recent history of Scandinavist ideas, the thesis identifies instrumental notions of kindredness and senses of cultural proprietorship extending to the output of the neighbouring countries. These notions were mobilised selectively within film culture and motivated practical transnational collaboration from the side of the authorities as well as in trade organisations.
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