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| 2. |
- Huus, Karina, et al.
(författare)
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Perceived needs among parents of children with a mild intellectual disability in Sweden
- 2017
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Ingår i: Scandinavian Journal of Disability Research. - : Taylor & Francis. - 1501-7419 .- 1745-3011. ; 19:4, s. 307-317
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Tidskriftsartikel (refereegranskat)abstract
- Parents of children with a mild intellectual disability experience more distress and require more support than other parents. The aim was to investigate the perceived family needs of parents of children with an MID and to investigate the relationship between parents’ perceived self-efficacy in their parental role and in collaborating with professionals as well as with their perceived needs for support. Interviews were based on questionnaires to the parents of 38 children. The results revealed that parents perceived need for information, respite, and venues in which to meet other parents in similar situations. The informational needs were related to parental self-efficacy and obtaining support. A lower need for information was related to higher perceived control over services. In conclusion, it appears that professionals need to work to strengthen parents’ ability to ask for support and to express the needs. Well-informed parents will develop stronger parental self-efficacy and perceived control over services.
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| 3. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 4. |
- Olofsson, Louise, 1977, et al.
(författare)
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CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides.
- 2008
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 93:12, s. 4880-6
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in adipogenesis and hepatic glucose and lipid metabolism. OBJECTIVE: The aim of the study was to test the hypothesis that adipose tissue C/EBPalpha regulates genes in lipid and glucose metabolism and to test for an association between a polymorphism in C/EBPalpha and metabolic parameters. DESIGN AND METHODS: Adipose tissue C/EBPalpha mRNA expression was analyzed at four time points in obese subjects with (n = 12) and without (n = 12) the metabolic syndrome during caloric restriction (450 kcal/d for 16 wk) using DNA microarray and real-time PCR. Adenoviral overexpression of C/EBPalpha was used to identify genes regulated by C/EBPalpha in 3T3-L1 cells. Association between a genetic variation in C/EBPalpha (rs12691) and metabolic parameters was tested in the Swedish Obese Subjects (SOS) study (n = 528) and replicated in Finnish individuals from the Botnia type 2 diabetes study (n = 4,866). RESULTS: During caloric restriction, adipose tissue C/EBPalpha mRNA levels were reduced in subjects with the metabolic syndrome (P = 0.024) and correlated to metabolic parameters. In 3T3-L1 cells, C/EBPalpha regulated the expression of adiponectin; hexokinase 2; lipoprotein lipase; diacylglycerol O-acyltransferase 1 and 2; ATP-binding cassette, sub-family D, member 2; acyl-coenzyme A synthetase long-chain family member 1; CD36; and hydroxysteroid 11-beta dehydrogenase 1. Furthermore, the expression of the human homologs, except adiponectin, correlated to C/EBPalpha mRNA levels in human adipose tissue. The AA genotype of rs12691 was associated with higher serum triglyceride levels in the SOS study (P = 0.022), and this association was replicated in the Botnia study (P = 0.041). CONCLUSIONS: Adipose tissue C/EBPalpha regulates several genes in glucose and lipid metabolism, and a genetic variation in C/EBPalpha is associated with triglycerides in two independent populations.
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| 5. |
- Sandström, Gabriella, 1970-, et al.
(författare)
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Kan en myndighet vara rolig? [poddavsnitt]
- 2020
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Annan publikation (ljud/tal) (populärvet., debatt m.m.)abstract
- Är det okej för myndigheter att skoja till det i sociala medier? Eller är det rent av olämpligt? Det här avsnittet av Svenskan i samhället handlar om att kombinera klarspråk med humor i myndighetskommunikation.
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| 7. |
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| 8. |
- Bjursell, Mikael, 1977, et al.
(författare)
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Opposing effects of adiponectin receptors 1 and 2 on energy metabolism
- 2007
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Ingår i: DIABETES. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 56:3, s. 583-593
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Tidskriftsartikel (refereegranskat)abstract
- The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and influences the risk for developing obesity, type 2 diabetes, and cardiovascular disease. Adiponectin binds to two different seven-transmembrane domain receptors termed AdipoR1 and AdipoR2. To study the physiological importance of these receptors, AdipoR1 gene knockout mice (AdipoR1−/−) and AdipoR2 gene knockout mice (AdipoR2−/−) were generated. AdipoR1−/− mice showed increased adiposity associated with decreased glucose tolerance, spontaneous locomotor activity, and energy expenditure. However, AdipoR2−/− mice were lean and resistant to high-fat diet–induced obesity associated with improved glucose tolerance and higher spontaneous locomotor activity and energy expenditure and reduced plasma cholesterol levels. Thus, AdipoR1 and AdipoR2 are clearly involved in energy metabolism but have opposing effects.
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| 9. |
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| 10. |
- Gidhagen, Lars, et al.
(författare)
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Towards climate services for European cities : Lessons learnt from the Copernicus project Urban SIS
- 2020
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Ingår i: Urban Climate. - Amsterdam, Netherlands : Elsevier. - 2212-0955. ; 31
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Tidskriftsartikel (refereegranskat)abstract
- The growing share of Europe's population living in cities makes urban climate change impact assessment and adaptation a critical issue. The urban environment is characterized by its sensitivity to small-scale meteorological, hydrological and environmental processes. These are generally not fully described in climate models, largely because of the models' insufficient spatial resolution. The Urban SIS climate service offers historical and future simulated data downscaled to 1 km × 1 km resolution over selected European metropolitan areas. The downscaled data are subsequently used as input to air quality and hydrological impact models, all made available to users as Essential Climate Variables and Sectoral Impact Indicators through a web portal. This paper presents the Urban SIS climate service and demonstrates its functionality in a case study in Stockholm city, Sweden. Good model performance was attained for intra-city temperature gradients and small-scale precipitation extremes. Less positive results were obtained for large-scale precipitation and hydrology, mainly due to an insufficient domain size in the meteorological and climate modelling, in turn related to the substantial computational requirements. An uncertainty classification approach was developed to aid the interpretation and user application of the data. We hope our lessons learnt will support future efforts in this direction.
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