| 1. |
|
|
| 2. |
|
|
| 3. |
- Bengtsson, Margaretha, et al.
(author)
-
The Importance Of Coal In Swedish Iron Production
- 1980
-
In: Jernkontorets annaler med Bergsmannen : JkA : tidskrift för nordisk bergshantering. - Stockholm : Jernkontoret. - 0348-6559. ; 164:3, s. 61-61
-
Journal article (peer-reviewed)
|
|
| 4. |
- Dahlman, Ingrid, et al.
(author)
-
A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects
- 2005
-
In: Journal of Clinical Endocrinology and Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 90:10, s. 5834-5840
-
Journal article (peer-reviewed)abstract
- Context: Low-grade inflammation in adipose tissue may contribute to insulin resistance in obesity. However, the roles of individual inflammatory mediators in adipose tissue are poorly understood. Objectives: The objective of this study was to determine which inflammation markers are most overexpressed at the gene level in adipose tissue in human obesity and how this relates to corresponding protein secretion. Design: We examined gene expression profiles in 17 lean and 20 obese subjects. The secretory pattern of relevant corresponding proteins was examined in human sc adipose tissue or isolated fat cells in vitro and in vivo in several obese or lean cohorts. Results: In ranking gene expression, defined pathways associated with obesity and immune and defense responses scored high. Among seven markedly overexpressed chemokines, only monocyte chemoattractant protein 1 (MCP1) was released from adipose tissue and isolated fat cells in vitro. In obesity, the secretion and expression of MCP1 in adipose tissue pieces were more than 6- and 2-fold increased, respectively, but there was no change in circulating MCP1 levels. There was no net release of MCP1, but there was a net release of leptin, in vivo from adipose tissue into the circulation. Conclusions: Obesity is associated with the increased expression of several chemokine genes in adipose tissue. However, only MCP1 is secreted into the extracellular space, where it primarily acts as a local factor, because little or no spillover into the circulation occurs. MCP1 influences the function of adipocytes, is a recruitment factor for macrophages, and may be a crucial link among chemokines between adipose tissue inflammation and insulin resistance.
|
|
| 5. |
- Gustafsson, Mika, et al.
(author)
-
A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases
- 2015
-
In: Science Translational Medicine. - : AMER ASSOC ADVANCEMENT SCIENCE. - 1946-6234 .- 1946-6242. ; 7:313
-
Journal article (peer-reviewed)abstract
- Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally present after they are symptomatic. We hypothesized that early regulators of T cell-associated diseases could be found by identifying upstream transcription factors (TFs) in T cell differentiation and by prioritizing hub TFs that were enriched for disease-associated polymorphisms. A gene regulatory network (GRN) was constructed by time series profiling of the transcriptomes and methylomes of human CD4(+) T cells during in vitro differentiation into four helper T cell lineages, in combination with sequence-based TF binding predictions. The TFs GATA3, MAF, and MYB were identified as early regulators and validated by ChIP-seq (chromatin immunoprecipitation sequencing) and small interfering RNA knockdowns. Differential mRNA expression of the TFs and their targets in T cell-associated diseases supports their clinical relevance. To directly test if the TFs were altered early in disease, T cells from patients with two T cell-mediated diseases, multiple sclerosis and seasonal allergic rhinitis, were analyzed. Strikingly, the TFs were differentially expressed during asymptomatic stages of both diseases, whereas their targets showed altered expression during symptomatic stages. This analytical strategy to identify early regulators of disease by combining GRNs with genome-wide association studies may be generally applicable for functional and clinical studies of early disease development.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Jägerstad, Margaretha, et al.
(author)
-
Det finns inga färdiga svar
- 2010
-
In: Jordbruk som håller i längden. - Stockholm : Formas. - 9789154060436 ; , s. 345-349
-
Book chapter (pop. science, debate, etc.)
|
|
| 9. |
- Jägerstad, Margaretha, et al.
(author)
-
Det finns inga färdiga svar
- 2010
-
In: Jordbruk som håller i längden. - Stockholm : Formas. ; , s. 345-349
-
Book chapter (other academic/artistic)
|
|
| 10. |
- Larsson, Anna-Britta, et al.
(author)
-
Klinisk slutexamination i tandhygienistprogrammet vid fyra lärosäten
- 2009
-
Reports (pop. science, debate, etc.)abstract
- Den legitimerade tandhygienisten har en nyckelroll inom promotion och prevention i svensk tandvård. I arbetet som tandhygienist krävs att kunna arbeta självständigt och ta väl underbyggda beslut för att ge en god och säker vård. Syftet med projektet var att utveckla, pröva och utvärdera en modell för klinisk slutexamination utifrån de krav som ställs för att arbeta som legitimerad tandhygienist. Projektarbetet resulterade i en modell bestående av en teoretisk och en klinisk examination. Den teoretiska examinationen består av ett fiktivt patientfall medan den kliniska examinationen omfattar en realistisk patientsituation där studenten omhändertar och behandlar en patient. Den framtagna modellens styrka är att samtliga studenter vid de olika lärosätena examineras kliniskt efter samma bedömningsgrunder vilket borgar för en god och jämförbar kvalitet.
|
|
