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- Yulug, B., et al.
(författare)
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Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
- 2023
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Ingår i: Translational Neurodegeneration. - : Springer Science and Business Media LLC. - 2047-9158. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Alzheimer's disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals. CMA promotes mitochondrial fatty acid uptake from the cytosol, facilitates fatty acid oxidation in the mitochondria, and alleviates oxidative stress.Methods Here, we designed a randomised, double-blinded, placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD patients. One-dose CMA included 12.35 g L-serine (61.75%), 1 g nicotinamide riboside (5%), 2.55 g N-acetyl-L-cysteine (12.75%), and 3.73 g L-carnitine tartrate (18.65%). AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day 84. The primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment arms. The secondary aim of this study was to evaluate the safety and tolerability of CMA. A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD patients.Results We showed a significant decrease of AD Assessment Scale-cognitive subscale (ADAS-Cog) score on day 84 vs day 0 (P = 0.00001, 29% improvement) in the CMA group. Moreover, there was a significant decline (P = 0.0073) in ADAS-Cog scores (improvement of cognitive functions) in the CMA compared to the placebo group in patients with higher ADAS-Cog scores. Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis. Moreover, the plasma levels of proteins and metabolites associated with NAD + and glutathione metabolism were significantly improved after CMA treatment.Conclusion Our results indicate that treatment of AD patients with CMA can lead to enhanced cognitive functions and improved clinical parameters associated with phenomics, metabolomics, proteomics and imaging analysis.
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| 3. |
- Ballikaya, S., et al.
(författare)
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Thermoelectric and thermal stability improvements in Nano-Cu 2 Se included Ag 2 Se
- 2019
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Ingår i: Journal of Solid State Chemistry. - : Academic Press. - 0022-4596 .- 1095-726X. ; 273, s. 122-127
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Tidskriftsartikel (refereegranskat)abstract
- Recently, silver chalcogenides have attracted great attention due to their potential application for room temperature power generation and local cooling. In this work, we report the thermoelectric properties and thermal stability of bulk Ag 2 Se with nano-Cu 2 Se inclusions ((Ag 2 Se) 1-x (Cu 2 Se) x where x = 0, 0.02 and 0.05). Ag 2 Se samples were prepared via melting, annealing and the nanocomposite was prepared by ball milling this material with required amount of nano-Cu 2 Se; finally, the samples were consolidated by spark plasma sintering. High temperature and low temperature transport properties were assessed by the measurements of the Seebeck coefficient, electrical conductivity, thermal conductivity, and Hall coefficient. The phase composition and microstructure were explored by powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis, while the thermal stability of samples was investigated via heating microscopy and heat capacity measurement. Room temperature PXRD and SEM indicated that two separate phases of Ag 2 Se and Cu 2 Se form in nano-Cu 2 Se included composites. Heating microscopy and the heat capacity measurement indicate that the thermal stability of Ag 2 Se is enhanced with increasing nano-Cu 2 Se inclusions. The sign of the Seebeck coefficient, in agreement with the Hall coefficient, shows that electrons are the dominant carriers in all samples. The electrical conductivity of the samples increases and the Seebeck coefficient decreases with increasing amount of the nano-Cu 2 Se inclusion, likely due to augmented carrier concentration. Despite the larger electrical conductivity, the thermal conductivity is suppressed with nano-Cu 2 Se inclusions. A high power factor and reduced thermal conductivity lead to a maximum ZT value of 0.45 at 875 K for (Ag 2 Se) 1-x (nano-Cu 2 Se) x sample where x is 0.05.
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| 4. |
- Lundin, Magnus, et al.
(författare)
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Compton scattering from the deuteron and extracted neutron polarizabilities
- 2003
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Ingår i: Physical Review Letters. - 1079-7114. ; 90:19
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Tidskriftsartikel (refereegranskat)abstract
- Differential cross sections for Compton scattering from the deuteron were measured at MAX-Lab for incident photon energies of 55 and 66 MeV at nominal laboratory angles of 45degrees, 125degrees, and 135degrees. Tagged photons were scattered from liquid deuterium and detected in three NaI spectrometers. By comparing the data with theoretical calculations in the framework of a one-boson-exchange potential model, the sum and the difference of the isospin-averaged nucleon polarizabilities, alpha(N) + beta(N) = 17.4 +/- 3.7 and alpha(N) - beta(N) = 6.4 +/- 2.4 (in units of 10(-4) fm(3)), have been determined. By combining the latter with the global-averaged value for alpha(p) - beta(p) and using the predictions of the Baldin sum rule for the sum of the nucleon polarizabilities, we have obtained values for the neutron electric and magnetic polarizabilities of alpha(n) = 8.8 +/- 2.4(total) +/- 3.0(model) and beta(n) = 6.5 -/+ 2.4(total) -/+ 3.0(model), respectively.
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| 5. |
- Ortiz-Fernandez, Lourdes, et al.
(författare)
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Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study
- 2021
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Ingår i: American Journal of Human Genetics. - CAMBRIDGE, MA USA : Cell Press. - 0002-9297 .- 1537-6605. ; 108:1, s. 84-99
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Tidskriftsartikel (refereegranskat)abstract
- Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 and reinforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries. Functional analysis proposed plausible underlying disease mechanisms and pinpointed ETS2 as a potential causal gene for chr21q22 association. We also identified >60 candidate loci with suggestive association (p < 5 x 10(-s)) and devised a genetic risk score for Takayasu arteritis. Takayasu arteritis was compared to hundreds of other traits, revealing the closest genetic relatedness to inflammatory bowel disease. Epigenetic patterns within risk loci suggest roles for monocytes and B cells in Takayasu arteritis. This work enhances understanding of the genetic basis and pathophysiology of Takayasu arteritis and provides clues for potential new therapeutic targets.
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| 6. |
- Skeppstedt, O, et al.
(författare)
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The EUROBALL neutron wall - design and performance tests of neutron detectors
- 1999
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Ingår i: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. - : ELSEVIER SCIENCE BV. ; 421:3, s. 531-541
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The mechanical design of the EUROBALL neutron wall and neutron detectors, and their performance measured with a Cm-246,Cm-248 fission source are described. The array consists of 15 pseudohexaconical detector units subdivided into three, 149 mm high, herme
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