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- Beral, V, et al.
(författare)
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Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease
- 2002
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 87, s. 1234-45
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Tidskriftsartikel (refereegranskat)abstract
- Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1 % per 10 g per day, P < 0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers= 1.03, 95% CI 0.98 - 1.07, and for current smokers=0.99, 0.92 - 1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. (C) 2002 Cancer Research UK.
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| 3. |
- Spinoglio, L., et al.
(författare)
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- 2017
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Ingår i: Publications Astronomical Society of Australia. - : Cambridge University Press (CUP). - 1323-3580 .- 1448-6083. ; 34
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Tidskriftsartikel (refereegranskat)abstract
- IR spectroscopy in the range 12-230 mu m with the SPace IR telescope for Cosmology and Astrophysics (SPICA) will reveal the physical processes governing the formation and evolution of galaxies and black holes through cosmic time, bridging the gap between the James Webb Space Telescope and the upcoming Extremely Large Telescopes at shorter wavelengths and the Atacama Large Millimeter Array at longer wavelengths. The SPICA, with its 2.5-m telescope actively cooled to below 8 K, will obtain the first spectroscopic determination, in the mid-IR rest-frame, of both the star-formation rate and black hole accretion rate histories of galaxies, reaching lookback times of 12 Gyr, for large statistically significant samples. Densities, temperatures, radiation fields, and gas-phase metallicities will be measured in dust-obscured galaxies and active galactic nuclei, sampling a large range in mass and luminosity, from faint local dwarf galaxies to luminous quasars in the distant Universe. Active galactic nuclei and starburst feedback and feeding mechanisms in distant galaxies will be uncovered through detailed measurements of molecular and atomic line profiles. The SPICA's large-area deep spectrophotometric surveys will provide mid-IR spectra and continuum fluxes for unbiased samples of tens of thousands of galaxies, out to redshifts of z similar to 6.
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| 4. |
- Belete, A. Bewketu, et al.
(författare)
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Molecular gas kinematics in the nuclear region of nearby Seyfert galaxies with ALMA
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 654
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Tidskriftsartikel (refereegranskat)abstract
- Context. The study of the distribution, morphology, and kinematics of cold molecular gas in the nuclear and circumnuclear regions of active galactic nuclei (AGNs) helps to characterise and hence to quantify the impact of the AGNs on the host galaxy over its lifetime. Aims. We present the analysis of the molecular gas in the nuclear regions of three Seyfert galaxies, NGC 4968, NGC 4845, and MCG-06-30-15, using Atacama Large sub-Millimetre Array (ALMA) observations of the CO(2-1) emission line. The aim is to determine the kinematics of the gas in the central (∼1 kpc) region and thereby to probe nuclear fueling and feedback of AGNs. Methods. We used two different softwares, namely the 3D-Based Analysis of Rotating Object via Line Observations and DiskFit, to model the kinematics of the gas in the molecular disc, and thereby to determine the gas rotation and any kinematical perturbations. Results. Circular motions dominate the kinematics of the molecular gas in the central discs, mainly in NGC 4845 and MCG-06-30-15; however there is clear evidence of non-circular motions in the central (∼1 kpc) region of NGC 4845 and NGC 4968. The strongest non-circular motion is detected in the inner disc of NGC 4968, mainly along the minor kinematic axis, with a velocity ∼115 km s-1. Of all DiskFit models, the bisymmetric model is found to give the best fit for NGC 4968 and NGC 4845, indicating that the observed non-circular motions in the inner disc of these galaxies could result from the nuclear barred structure, where the gas streams in elliptical orbits aligned along the bar. If the dynamics of NGC 4968 is modelled as a corotation pattern just outside of the bar, the bar pattern speed becomes ωb = 52 km s-1 kpc-1; the corotation is set at 3.5 kpc; and the inner Lindblad resonance (ILR) ring is R = 300 pc, corresponding to the CO emission ring. In the NGC 4968 galaxy, the torques exerted on the gas by the bar are positive in the centre, within the gas nuclear ring, and negative outside. This shows that the gas is transiently trapped in the ILR. The comparison of the CO intensity maps with the map of the cold dust emission shows an absence of CO in the centre of NGC 4968; also the dust distribution and CO emission in and around the centre of NGC 4845 have similar extensions. The 1.2 mm ALMA continuum is peaked and compact in NGC 4968 and MCG-06-30-15, but their CO(2-1) emissions have extended distributions. Allowing the CO-to-H2 conversion factor αCO between 0.8 and 3.2, which is typical of nearby galaxies of the same type, the molecular mass M(H2) is estimated to be ∼3 - 12 × 107 M⊙ (NGC 4968), ∼9 - 36 × 107 M⊙ (NGC 4845), and ∼1 - 4 × 107 M⊙ (MCG-06-30-15). Conclusions. We conclude that the observed non-circular motions in the molecular disc of NGC 4968 and likely those seen in NGC 4845 are due to the presence of the bar in the nuclear region. We discuss the possibility that the observed pattern in the kinematics might be a consequence of the presence of AGNs, and this might be the case for NGC 4845. At the current spectral and spatial resolution and sensitivity, we cannot claim any strong evidence in these sources of the long sought feedback or feeding effect resulting from the presence of AGNs.
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| 5. |
- Fernandez-Ontiveros, J. A., et al.
(författare)
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A CO molecular gas wind 340 pc away from the Seyfert 2 nucleus in ESO420-G13 probes an elusive radio jet*
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 633
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Tidskriftsartikel (refereegranskat)abstract
- A prominent jet-driven outflow of CO(2-1) molecular gas is found along the kinematic minor axis of the Seyfert 2 galaxy ESO 420-G13, at a distance of 340-600 pc from the nucleus. The wind morphology resembles the characteristic funnel shape, formed by a highly collimated filamentary emission at the base, and likely traces the jet propagation through a tenuous medium, until a bifurcation point at 440 pc. Here the jet hits a dense molecular core and shatters, dispersing the molecular gas into several clumps and filaments within the expansion cone. We also trace the jet in ionised gas within the inner less than or similar to 340 pc using the [NeII](12.8 mu m) line emission, where the molecular gas follows a circular rotation pattern. The wind outflow carries a mass of similar to 8 x 10(6) M-circle dot at an average wind projected speed of similar to 160 km s(-1), which implies a mass outflow rate of similar to 14 M-circle dot yr(-1). Based on the structure of the outflow and the budget of energy and momentum, we discard radiation pressure from the active nucleus, star formation, and supernovae as possible launching mechanisms. ESO 420-G13 is the second case after NGC 1377 where a previously unknown jet is revealed through its interaction with the interstellar medium, suggesting that unknown jets in feeble radio nuclei might be more common than expected. Two possible jet-cloud configurations are discussed to explain an outflow at this distance from the AGN. The outflowing gas will likely not escape, thus a delay in the star formation rather than quenching is expected from this interaction, while the feedback effect would be confined within the central few hundred parsecs of the galaxy.
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