| 1. |
- Brugulat-Serrat, Anna, et al.
(författare)
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APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
- 2023
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Ingår i: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [18F]flutemetamol Aβ positron emission tomography (PET), T1w magnetic resonance imaging (MRI), as well as APOE genotyping. Global and regional Aβ PET positivity was assessed across five regions-of-interest by visual reading (VR) and regional Centiloids. Linear regression models were developed to examine the interaction between regional and global Aβ PET positivity and APOE-ε4 status on longitudinal cognitive change assessed with the Preclinical Alzheimer’s Cognitive Composite (PACC), episodic memory, and executive function, after controlling for age, sex, education, cognitive baseline scores, and hippocampal volume. Results: In total, 57 participants (16.2%) were VR+ of whom 41 (71.9%) were APOE-ε4 carriers. No significant APOE-ε4*global Aβ PET interactions were associated with cognitive change for any cognitive test. However, APOE-ε4 carriers who were VR+ in temporal areas (n = 19 [9.81%], p = 0.04) and in the striatum (n = 8 [4.14%], p = 0.01) exhibited a higher decline in the PACC. The temporal areas findings were replicated when regional PET positivity was determined with Centiloid values. Regionally, VR+ in the striatum was associated with higher memory decline. As for executive function, interactions between APOE-ε4 and regional VR+ were found in temporal and parietal regions, and in the striatum. Conclusion: CU APOE-ε4 carriers with a positive Aβ PET VR in regions known to accumulate amyloid at later stages of the Alzheimer’s disease (AD) continuum exhibited a steeper cognitive decline. This work supports the contention that regional VR of Aβ PET might convey prognostic information about future cognitive decline in individuals at higher risk of developing AD. ClinicalTrials.gov Identifier: NCT02485730. Registered 20 June 2015 https://clinicaltrials.gov/ct2/show/NCT02485730 and ClinicalTrials.gov Identifier:NCT02685969. Registered 19 February 2016 https://clinicaltrials.gov/ct2/show/NCT02685969.
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| 2. |
- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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| 3. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Akinci, Muge, et al.
(författare)
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Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic : what is the role of stress perception, stress resilience, and β-amyloid?
- 2022
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Ingår i: Alzheimer's Research and Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity of SCD and anxious/depressive symptoms during confinement and the underlying mechanisms. Methods: Two hundred fifty cognitively unimpaired participants completed the Hospital Anxiety and Depression Scale (HADS) and SCD-Questionnaire (SCD-Q) and underwent amyloid-β positron emission tomography imaging with [18F] flutemetamol (N = 205) on average 2.4 (± 0.8) years before the COVID-19 confinement. During the confinement, participants completed the HADS, Perceived Stress Scale (PSS), Brief Resilience Scale (BRS), and an ad hoc questionnaire on worries (access to primary products, self-protection materials, economic situation) and lifestyle changes (sleep duration, sleep quality, eating habits). We investigated stress-related measurements, worries, and lifestyle changes in relation to SCD. We then conducted an analysis of covariance to investigate the association of SCD-Q with HADS scores during the confinement while controlling for pre-confinement anxiety/depression scores and demographics. Furthermore, we introduced amyloid-β positivity, PSS, and BRS in the models and performed mediation analyses to explore the mechanisms explaining the association between SCD and anxiety/depression. Results: In the whole sample, the average SCD-Q score was 4.1 (± 4.4); 70 (28%) participants were classified as SCD, and 26 (12.7%) were amyloid-β-positive. During the confinement, participants reporting SCD showed higher PSS (p = 0.035) but not BRS scores (p = 0.65) than those that did not report SCD. No differences in worries or lifestyle changes were observed. Higher SCD-Q scores showed an association with greater anxiety/depression scores irrespective of pre-confinement anxiety/depression levels (p = 0.002). This association was not significant after introducing amyloid-β positivity and stress-related variables in the model (p = 0.069). Amyloid-β positivity and PSS were associated with greater HADS irrespective of pre-confinement anxiety/depression scores (p = 0.023; p < 0.001). The association of SCD-Q with HADS was mediated by PSS (p = 0.01). Conclusions: Higher intensity of SCD, amyloid-β positivity, and stress perception showed independent associations with anxious/depressive symptoms during the COVID-19 confinement irrespective of pre-confinement anxiety/depression levels. The association of SCD intensity with anxiety/depression was mediated by stress perception, suggesting stress regulation as a potential intervention to reduce affective symptomatology in the SCD population in the face of stressors.
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| 5. |
- Arnela, Marc, et al.
(författare)
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A semi-polar grid strategy for the three-dimensional finite element simulation of vowel-vowel sequences
- 2017
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Ingår i: Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH 2017. - : The International Speech Communication Association (ISCA). ; , s. 3477-3481
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Konferensbidrag (refereegranskat)abstract
- Three-dimensional computational acoustic models need very detailed 3D vocal tract geometries to generate high quality sounds. Static geometries can be obtained from Magnetic Resonance Imaging (MRI), but it is not currently possible to capture dynamic MRI-based geometries with sufficient spatial and time resolution. One possible solution consists in interpolating between static geometries, but this is a complex task. We instead propose herein to use a semi-polar grid to extract 2D cross-sections from the static 3D geometries, and then interpolate them to obtain the vocal tract dynamics. Other approaches such as the adaptive grid have also been explored. In this method, cross-sections are defined perpendicular to the vocal tract midline, as typically done in 1D to obtain the vocal tract area functions. However, intersections between adjacent cross-sections may occur during the interpolation process, especially when the vocal tract midline quickly changes its orientation. In contrast, the semi-polar grid prevents these intersections because the plane orientations are fixed over time. Finite element simulations of static vowels are first conducted, showing that 3D acoustic wave propagation is not significantly altered when the semi-polar grid is used instead of the adaptive grid. The vowel-vowel sequence [ɑi] is finally simulated to demonstrate the method.
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| 6. |
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| 7. |
- Arnela, Marc, et al.
(författare)
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Finite element generation of vowel sounds using dynamic complex three-dimensional vocal tracts
- 2016
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Ingår i: Proceedings of the 23rd international congress on sound and vibration. - : INT INST ACOUSTICS & VIBRATION. - 9789609922623
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Konferensbidrag (refereegranskat)abstract
- Three-dimensional (3D) numerical simulations of the vocal tract acoustics require very detailed vocal tract geometries in order to generate good quality vowel sounds. These geometries are typically obtained from Magnetic Resonance Imaging (MRI), from which a volumetric representation of the complex vocal tract shape is obtained. Static vowel sounds can then be generated using a finite element code, which simulates the propagation of acoustic waves through the vocal tract when a given train of glottal pulses is introduced at the glottal cross-section. A more challenging problem to solve is that of generating dynamic vowel sounds. On the one hand, the acoustic wave equation has to be solved in a computational domain with moving boundaries, which entails some numerical difficulties. On the other hand, the finite element meshes where acoustic wave propagation is computed have to move according to the dynamics of these very complex vocal tract shapes. In this work this problem is addressed. First, the acoustic wave equation in mixed form is expressed in an Arbitrary Lagrangian-Eulerian (ALE) framework to account for the vocal tract wall motion. This equation is numerically solved using a stabilized finite element approach. Second, the dynamic 3D vocal tract geometry is approximated by a finite set of cross-sections with complex shape. The time-evolution of these cross-sections is used to move the boundary nodes of the finite element meshes, while inner nodes are computed through diffusion. Some dynamic vowel sounds are presented as numerical examples.
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| 8. |
- Arnela, Marc, et al.
(författare)
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Influence of lips on the production of vowels based on finite element simulations and experiments
- 2016
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Ingår i: Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966 .- 1520-8524. ; 139:5, s. 2852-2859
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Tidskriftsartikel (refereegranskat)abstract
- Three-dimensional (3-D) numerical approaches for voice production are currently being investigated and developed. Radiation losses produced when sound waves emanate from the mouth aperture are one of the key aspects to be modeled. When doing so, the lips are usually removed from the vocal tract geometry in order to impose a radiation impedance on a closed cross-section, which speeds up the numerical simulations compared to free-field radiation solutions. However, lips may play a significant role. In this work, the lips' effects on vowel sounds are investigated by using 3-D vocal tract geometries generated from magnetic resonance imaging. To this aim, two configurations for the vocal tract exit are considered: with lips and without lips. The acoustic behavior of each is analyzed and compared by means of time-domain finite element simulations that allow free-field wave propagation and experiments performed using 3-D-printed mechanical replicas. The results show that the lips should be included in order to correctly model vocal tract acoustics not only at high frequencies, as commonly accepted, but also in the low frequency range below 4 kHz, where plane wave propagation occurs.
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| 9. |
- Arnela, Marc, et al.
(författare)
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Influence of vocal tract geometry simplifications on the numerical simulation of vowel sounds
- 2016
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Ingår i: Journal of the Acoustical Society of America. - : Acoustical Society of America (ASA). - 0001-4966 .- 1520-8524. ; 140:3, s. 1707-1718
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Tidskriftsartikel (refereegranskat)abstract
- For many years, the vocal tract shape has been approximated by one-dimensional (1D) area functions to study the production of voice. More recently, 3D approaches allow one to deal with the complex 3D vocal tract, although area-based 3D geometries of circular cross-section are still in use. However, little is known about the influence of performing such a simplification, and some alternatives may exist between these two extreme options. To this aim, several vocal tract geometry simplifications for vowels [ɑ], [i], and [u] are investigated in this work. Six cases are considered, consisting of realistic, elliptical, and circular cross-sections interpolated through a bent or straight midline. For frequencies below 4–5 kHz, the influence of bending and cross-sectional shape has been found weak, while above these values simplified bent vocal tracts with realistic cross-sections are necessary to correctly emulate higher-order mode propagation. To perform this study, the finite element method (FEM) has been used. FEM results have also been compared to a 3D multimodal method and to a classical 1D frequency domain model.
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| 10. |
- Arnela, Marc, et al.
(författare)
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MRI-based vocal tract representations for the three-dimensional finite element synthesis of diphthongs
- 2019
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Ingår i: IEEE Transactions on Audio, Speech, and Language Processing. - : IEEE Press. - 1558-7916 .- 1558-7924. ; 27:12, s. 2173-2182
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of diphthongs in three-dimensions (3D) involves the simulation of acoustic waves propagating through a complex 3D vocal tract geometry that deforms over time. Accurate 3D vocal tract geometries can be extracted from Magnetic Resonance Imaging (MRI), but due to long acquisition times, only static sounds can be currently studied with an adequate spatial resolution. In this work, 3D dynamic vocal tract representations are built to generate diphthongs, based on a set of cross-sections extracted from MRI-based vocal tract geometries of static vowel sounds. A diphthong can then be easily generated by interpolating the location, orientation and shape of these cross-sections, thus avoiding the interpolation of full 3D geometries. Two options are explored to extract the cross-sections. The first one is based on an adaptive grid (AG), which extracts the cross-sections perpendicular to the vocal tract midline, whereas the second one resorts to a semi-polar grid (SPG) strategy, which fixes the cross-section orientations. The finite element method (FEM) has been used to solve the mixed wave equation and synthesize diphthongs [${\alpha i}$] and [${\alpha u}$] in the dynamic 3D vocal tracts. The outputs from a 1D acoustic model based on the Transfer Matrix Method have also been included for comparison. The results show that the SPG and AG provide very close solutions in 3D, whereas significant differences are observed when using them in 1D. The SPG dynamic vocal tract representation is recommended for 3D simulations because it helps to prevent the collision of adjacent cross-sections.
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