| 1. |
- Aspholm-Hurtig, Marina, et al.
(författare)
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Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
- 2004
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5683, s. 519-22
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Tidskriftsartikel (refereegranskat)abstract
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
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| 2. |
- Petrenya, N., et al.
(författare)
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Relationship between periodontitis and risk of cardiovascular disease: Insights from the Tromso Study
- 2022
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Ingår i: Journal of Periodontology. - : Wiley. - 0022-3492 .- 1943-3670. ; 93:9, s. 1353-1365
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Tidskriftsartikel (refereegranskat)abstract
- Background Few large-scale studies have investigated the association between periodontitis and cardiovascular risk estimated by risk assessment models; moreover, this association remains unexplored in never-smokers. We aimed to examine the relationship between periodontitis and cardiovascular risk in a Norwegian general population, with a focus on never-smokers and the impact of sex and age. Methods The present study included 2623 participants from the seventh survey of the Tromso Study (Tromso7, 2015-2016), aged 45-74 years, and without previous myocardial infarction or stroke. Periodontitis was defined according to the 2017 American Academy of Periodontology and the European Federation of Periodontology classification system. Participants were categorized by grade based on percentage bone loss/age as no periodontitis/Grade A (low progression rate) and Grade B/C (moderate-rapid progression rate). Low, medium, and high cardiovascular risk was defined based on the Norwegian risk model NORRISK 2. We used ordered logistic regression analysis to examine the association between periodontitis and cardiovascular risk, adjusting for education, toothbrushing frequency, body mass index, and diabetes. Subanalyses included stratification by sex and age (45-54, 55-64, 65-74 years) and a separate analysis of never-smokers. Results Periodontitis Grade B/C was associated with higher cardiovascular risk than no periodontitis/Grade A (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.75-2.61). This association was significant in both men and women, all age groups, and never-smokers. However, when never-smokers were stratified by age, the association remained significant only in those aged 65-74 years (OR, 3.00; 95% CI, 1.50-5.99). Conclusion Periodontitis Grade B/C was associated with higher cardiovascular risk overall, and in never-smokers aged 65-74 years.
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| 3. |
- Bongo, A. K. S., et al.
(författare)
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Periodontal health in an indigenous Sami population in Northern Norway: a cross-sectional study
- 2020
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Ingår i: Bmc Oral Health. - : Springer Science and Business Media LLC. - 1472-6831. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Background The aim of the study was to describe prevalence, severity and distribution of periodontal disease as well as associated risk factors in an indigenous Sami population in Northern Norway, and to investigate differences between the indigenous Sami and the non-Sami population. Methods This cross-sectional study included data from the Dental Health in the North study (N = 2078; 18-75 years). Data on Ethnicity, household income, education, smoking habits, dental attendance, and tooth brushing habits were collected by a questionnaire. Periodontal conditions were assessed by clinical examination. A modified version of the new AAP/EFP classification system of periodontal disease was used to estimate the severity of periodontitis. Three stages were used: 'Non-severe periodontitis', 'Stage II', and stage 'III/IV'. Results Of the total study population 66.5% reported Sami affiliation. The total prevalence of periodontitis was 49.7%, with 20.1% in Stage III/IV, but no differences between Sami and non-Sami. When controlled for sex, age, education, smoking and dental attendance the Sami had higher probability of having more severe stages of periodontitis; Odds Ratio(Stage II) (OR) = 1.3; 95% CI: 1.1-1.7; and ORStage III/IV (OR) = 1.6; 95% CI: 1.1-2.2) compared to non-Sami. The Sami had higher prevalence of periodontal pocket depth (PD) >= 4 mm (t = 1.77; p < 0.001) and PD >= 6 mm (t = 1.08; p = 0.038) than the non-Sami. Conclusions The prevalence of periodontitis was high in communities in the core area of Sami settlement in Northern Norway, regardless of ethnicity. People with Sami ethnicity had more deep periodontal pockets and an increased odds of having severe stages of periodontitis. Future studies should address possible explaining factors behind the potential higher risk of having more severe periodontitis among indigenous people in Sami settlements.
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| 4. |
- Brustad, M., et al.
(författare)
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Oral health in the indigenous Sami population in Norway - the dental health in the North study
- 2020
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Ingår i: Acta Odontologica Scandinavica. - : Informa UK Limited. - 0001-6357 .- 1502-3850. ; 78:2, s. 98-108
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study aims at presenting the feasibility of using the public oral health clinics in indigenous Sami communities, as arena for a comprehensive data collection for population-based epidemiological oral health research among adults (age, 18-75 years) in a multi-ethnic setting. Material and methods: The study design was cross-sectional. The data collection was incorporated into the clinical procedure at six public dental clinics situated in the Administrative Area for the Sami Language in Finnmark County, Northern Norway, during 2013-2014. Both clinical- and questionnaire-data were collected. The quality of clinical data was thoroughly calibrated and validated. Results: Altogether, 2235 people participated in the study gave a crude response rate at 88.7%. In the final data sample (n = 2034), 56.9% were female. We constructed three ethnic groups (Sami, Mixed Sami/Norwegian and Norwegian). Altogether, 67.7% reported Sami or mixed Sami ethnicity. The internal validity of the clinical data was found to be satisfactory when assessed by comprehensive quality procedure, calibration and reliability assessments. Conclusion: This study design and method assessments provide solid documentation that public dental clinics are suitable as arenas for data collection in epidemiological oral health studies in the Sami population in this region.
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| 5. |
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| 6. |
- Hadler-Olsen, E., et al.
(författare)
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Temporomandibular disorders in an adult population in northern Norway: A cross-sectional study
- 2021
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Ingår i: Clinical and Experimental Dental Research. - : Wiley. - 2057-4347. ; 7:6, s. 1144-1153
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of the study was to assess the prevalence of symptoms indicative of temporomandibular disorders (TMD) in an adult population in Troms County in Northern Norway, as well as the associations between TMD and socio-demographic factors, dental status, self-reported general, and oral health as well as oral health related quality of life (OHQoL). Methods: Data were collected from a structured questionnaire and a clinical examination of a random sample of almost 2000 adults, 20-79-year-old, in Troms County in Northern Norway. Results: Women had a higher prevalence of all self-reported and clinical signs of pain and dysfunction in the temporomandibular complex compared to men. For both genders, sounds from the temporomandibular joint (TMJ) upon clinical examination was the most common symptom, followed by pain to palpation of jaw muscles. Headache was the most common of the self-reported symptoms and sounds from the TMJ the second most common. Young women had a higher prevalence of self-reported headache and jaw- and face pain compared to middle-aged and elderly women. TMD-related symptoms of pain were significantly associated with poor self-reported general health and correlated with OHQoL as assessed by the oral health impact profile 14 questionnaire. Conclusion: Being women and having moderate to poor self-reported general health were associated with clinical signs and self-reported symptoms of pain in the jaw, face and head region. Self-reported symptoms of TMD correlated more strongly with OHQoL than clinical signs.
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| 7. |
- Holde, G. E., et al.
(författare)
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To what extent does smoking affect gingival bleeding response to supragingival plaque? Site-specific analyses in a population-based study
- 2020
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Ingår i: Journal of Periodontal Research. - : Wiley. - 0022-3484 .- 1600-0765. ; 55:2, s. 277-286
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Tidskriftsartikel (refereegranskat)abstract
- Background and objective The aim of this study was to investigate the influence of smoking on the site-specific association between bleeding on gingival probing and supragingival plaque and to assess whether this differs in different regions of the dentition. Methods Data from a representative sample of 1911 adults (20-79 years old) in Northern Norway were analyzed. Periodontal examinations consisted of full-mouth recordings of periodontal probing depth (PD), bleeding on probing (BOP), and presence of supragingival plaque. Smoking status and background characteristics were self-reported by questionnaire. The association between plaque and BOP was assessed in several three-level (subject, tooth, and site) random intercept logistic regression models adjusted for PD, smoking status, socioeconomic factors, and body mass index. In a further model, it was assessed whether the association between supragingival plaque and BOP differed in different parts of the dentition. Results For plaque-free sites, bleeding tendency was lower in smokers, the odds ratio (OR) was 0.773 with a 95% confidence interval of 0.678-0.881 as compared to non-smokers (OR: 1; ref., P < .001). The odds of BOP at plaque-covered sites in non-smokers were increased twofold (OR: 2.117; 2.059-2.177). Albeit bleeding tendency was slightly increased in plaque-covered sites in smokers, it was considerably lower as compared to plaque-covered sites in non-smokers (OR: 1.459; 1.282-1.662, P < .001). Smoking >= 20 pack-years further attenuated the association. In smokers, the odds of BOP were reduced in all parts of the dentition, lower and upper anterior and posterior teeth (chi(4)2= 32.043, P < .001). When restricting the data to younger adults (20-34 year old), smoking had only a slight effect on the association between plaque and BOP. For plaque-free and plaque-covered sites, differences in ORs were not statistically noticeable (P = .221 and P = .235, respectively). Conclusions Smoking considerably attenuates the site-specific association between plaque and BOP with a dose-dependent effect. The effect of smoking did not differ across tooth types.
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