| 1. |
- Bejhed Stjernberg, Rebecca, et al.
(author)
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Magnetophoretic Transport Line System for Rapid On-Chip Attomole Protein Detection
- 2015
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In: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 31:37, s. 10296-10302
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Journal article (peer-reviewed)abstract
- A lab-on-a-chip traveling wave magnetophoresis approach for sensitive and rapid protein detection is reported. In this method, a chip-based magnetic microarray comprising lines of micrometer-sized thin film magnetic elements was used to control the movement of magnetic beads (MBs). The MBs and the chip were functionalized, forming a sandwich-type assay. The MBs were transported across a detection area, and the presence of target molecules resulted in the immobilization of MBs within this area. Target quantification was accomplished by MB counting in the detection area using an optical microscope. In order to demonstrate the versatility of the microarray, biotinylated antiavidin was selected as the target protein. In this case, avidin-functionalized MBs and an avidin-functionalized detection area were used. With a total assay time of 1 to 1.5 h (depending on the labeling approach used), a limit of detection in the attomole range was achieved. Compared to on-chip surface plasmon resonance biodetection systems, our method has a larger dynamic range and is about a factor of 500 times more sensitive. Furthermore, our MB transportation system can operate in any chip-based biosensor platform, thereby significantly improving traditional biosensors.
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| 2. |
- Bohlooly-Yeganeh, Mohammad, 1966, et al.
(author)
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Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.
- 2005
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In: Diabetes. - 0012-1797 .- 1939-327X. ; 54:1, s. 51-62
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Journal article (peer-reviewed)abstract
- It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that on appetite. The transgenic mice were not GH-deficient but were obese and showed increased food intake as well as increased hypothalamic expression of agouti-related protein and neuropeptide Y. GH also had an acute effect on food intake following intracerebroventricular injection of C57BL/6 mice. The transgenic mice were severely hyperinsulinemic and showed a marked hyperplasia of the islets of Langerhans. In addition, the transgenic mice displayed alterations in serum lipid and lipoprotein levels and hepatic gene expression. In conclusion, GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect.
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| 3. |
- Magnusson, Johan, et al.
(author)
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All Aboard: ERP Implementation as Participatory Design
- 2011
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In: Americas Conference on Information Systems.
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Conference paper (other academic/artistic)abstract
- Following a previous description of Enterprise Resource Planning (ERP) implementations as participatory design (Pries-Heje & Dittrich, 2009), this paper explores the case of a medium-sized, family-owned manufacturing company and its endeavors with changing their current ERP system. The case was selected on the premise of it being perceived a success by the involved stakeholders. Through a series of interviews and analysis of secondary material, the case covers the period between 1995 and 2010. As the results show, several instances of user involvement and participation can be found throughout the case. According to the respondents, this is seen as one of the central elements of the success. This is discussed in relation to previous findings and a call for future research into ERP implementation is presented.
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| 4. |
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| 5. |
- Olsson, Anders, 1973-, et al.
(author)
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Dynamic excitation and higher bending modes for prediction oftimber bending strength
- 2010
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In: <em>Proceedings of the final conference of COST action E53</em>.
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Conference paper (other academic/artistic)abstract
- The potential of utilizing eigenfrequencies corresponding to edgewise bending modes for predicting the bending strength of timber is investigated. The research includes measurements of axial and transversal resonance frequencies, laboratory assessment of density, static bending stiffness and bending strength of 105 boards of Norway spruce of dimensions 45×145×3600 mm. It is shown that Eb,1, (MOE based on the eigenfrequency of the first bending mode) gives a higher coefficient of determination to the bending strength than what Ea,1 (MOE based on the first axial eigenfrequency) does. It is also shown that eigenfrequencies corresponding to higher bending modes can be used in the definition of a new prediction variable, the modulus of inhomogeneity (MOI). This is a scalar value representing the lack of fit between the true, measured eigenfrequencies and the expected (assuming homogeneity) eigenfrequencies of a board. The results show that using the MOI as a third prediction variable, in addition to Eb,1 and density, increases the coefficient of determination with respect to bending strength from R2 = 0.69 to R2 = 0.75.
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| 6. |
- Olsson, Anders, 1973-, et al.
(author)
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Förfarande och anordning för utvärdering av en bräda av trä
- 2014
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Patent (pop. science, debate, etc.)abstract
- Föreliggande redogörelse avser en metod och en anordning för utvärdering av en bräda av trä med en ländriktning. Data som indikerar fiberorienteringen över brädans yta inhämtas och för ett antal underpartier hos brädan bestäms en nominell, lokal elasticitetsmodul, MOE, på basis av nämnda fiberorienteringsdata och en nominell materialparameter. En nominell global MOE i längdriktningen för träbrädan i sin helhet genereras och jämförs med en sekundär global MOE. På basis av nämnda fiberorienteringsdata och denna jämförelse genereras en uppskattad lokal elasticitetsmodul, MOE, i nämnda längdriktning för ett flertal underpartier. Dessa data kan användas för exempelvis tillförlitlig hållfasthetsgradering av träbrädor.
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| 7. |
- Olsson, Anders, 1973-, et al.
(author)
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Nytt paradigm för hållfasthetssortering av konstruktionsvirke : Projektrapport två
- 2014
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Reports (other academic/artistic)abstract
- Undersökningen som redovisas i denna rapport har genomförts under hösten 2013 och våren 2014 inom projektet "Nytt paradigm för hållfasthetssortering av konstruktionsvirke". Projektet, som pågår under perioden december 2011 till juni 2014, går ut på att för industriellt bruk utveckla en nyligen föreslagen metod för hållfasthetssortering av konstruktionsvirke, vilken baseras på laserskanning i kombination med dynamisk excitering och densitetsbestämning av virke. Projektet finansieras till 50 % av VINNOVA och till 50 % av de företag som medverkar i projektet, nämligen Innovativ Vision AB (IV), Vida Vislanda AB, Södra Timber AB, Derome Timber AB och Dynalyse AB. Linnéuniversitetet (Lnu) och SP Sveriges Tekniska Forskningsinstitut AB (SP) samverkar med nämnda företag i utförandet av forskningen.Ett syfte med undersökningen är att på ett stort material bestående av många olika virkesdimensioner verifiera de starka statistiska samband som sedan tidigare påvisats för ett begränsat antal plankor och dimensioner, mellan å ena sidan indikerande egenskaper som baseras på mätningar och beräkningar och å andra sidan böjstyrka, elasticitetsmodul och densitet. Ett annat syfte med undersökningen är att visa att nödvändig data kan samlas in av samma utrustning och under samma förhållanden som kommer att gälla vid framtida hållfasthetssortering baserad på den aktuella metoden. Slutligen är ett syfte att samla in och dokumentera data som kan användas för forskning och utveckling både inom och efter det att det aktuella projektet har avslutats.
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| 8. |
- Olsson, Anders, 1973-, et al.
(author)
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Nytt paradigm för hållfasthetssortering av konstruktionsvirke : Projektrapport ett
- 2013
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Reports (other academic/artistic)abstract
- Den undersökning som redovisas i denna rapport har genomförts under hösten 2012 och våren 2013 inom projektet "Nytt paradigm för hållfasthetssortering av konstruktionsvirke". Projektet som kommer att pågå under perioden december 2011 till juni 2014 går ut på att för industriellt bruk utveckla en nyligen föreslagen metod för hållfasthetssortering av konstruktionsvirke, vilken baseras på laserskanning i kombination med dynamisk excitering och densitetsbestämning av virke. Projektet finansieras till 50 % av VINNOVA och till 50 % av de företag som medverkar i projektet, nämligen Innovativ Vision AB (IV), Vida Vislanda AB, Södra Timber AB, Derome Timber AB och Dynalyse AB. Linnéuniversitetet (Lnu) och SP Sveriges Tekniska Forskningsinstitut AB (SP) samverkar med nämnda företag i utförandet av forskningen.Syftet med undersökningen är i först hand att utvärdera alternativa sätt för att bestämma densitet för virke och att verifiera implementeringen av programvara för industriellt bruk. Syftet är också att ta fram ett utökat material för att bedöma vilken precision den nya sorteringsmetoden kan erbjuda och för att bedöma hur känslig den är för olika typer förändringar och störningar som kan uppkomma. Undersökningen bygger på ett begränsat material och en mer omfattande undersökning planeras för genomförande under senare delar av projektet.
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| 9. |
- Olsson, Anders, 1973-, et al.
(author)
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Prediction of timber bending strength and in-member cross-sectional stiffness vartiation on basis of local wood fibre orientation
- 2013
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In: European Journal of Wood and Wood Products. - : Springer. - 0018-3768 .- 1436-736X. ; 71:3, s. 319-333
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Journal article (peer-reviewed)abstract
- Machine strength grading of structural timber is based upon relationships between so called indicating properties (IPs) and bending strength. However, such relationships applied on the market today are rather poor. In this paper, new IPs and a new grading method resulting in more precise strength predictions are presented. The local fibre orientation on face and edge surfaces of wooden boards was identified using high resolution laser scanning. In combination with knowledge regarding basic wood material properties for each investigated board, the grain angle information enabled a calculation of the variation of the local MOE in the longitudinal direction of the boards. By integration over cross-sections along the board, an edgewise bending stiffness profile and a longitudinal stiffness profile, respectively, were calculated. A new IP was defined as the lowest bending stiffness determined along the board. For a sample of 105 boards of Norway spruce of dimension 45 × 145 × 3600 mm, a coefficient of determination as high as 0.68-0.71 was achieved between this new IP and bending strength. For the same sample, the coefficient of determination between global MOE, based on the first longitudinal resonance frequency and the board density, and strength was only 0.59. Furthermore, it is shown that improved accuracy when determining the stiffness profiles of boards will lead to even better predictions of bending strength. The results thus motivate both an industrial implementation of the suggested method and further research aiming at more accurately determined board stiffness profiles.
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| 10. |
- Olsson, Anders, 1973-, et al.
(author)
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Prediction of timber bending strength on basis of bending stiffness and material homogeneity assessed from dynamic excitation
- 2012
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In: Wood Science and Technology. - : Springer Science and Business Media LLC. - 0043-7719 .- 1432-5225. ; 46:4, s. 667-683
-
Journal article (peer-reviewed)abstract
- The potential of utilizing resonance frequencies corresponding to edgewise bending modes for predicting the bending strength of timber is investigated. The research includes measurements of axial and transversal resonance frequencies, laboratory assessment of density, static bending stiffness and bending strength of 105 boards of Norway spruce of dimensions 45×145×3600 mm. It is shown that Eb,1, (MOE based on the resonance frequency of the first bending mode) gives a higher coefficient of determination to the bending strength than what Ea,1 (MOE based on the first axial resonance frequency) does. It is also shown that resonance frequencies corresponding to higher bending modes can be used in the definition of a new indicating property, the measure of inhomogeneity (MOI). This is a scalar value representing the lack of fit between the true, measured resonance frequencies and the expected (assuming homogeneity) resonance frequencies of a board. The results show that using the MOI as a third indicating property, in addition to Eb,1 and density, increases the coefficient of determination with respect to bending strength from R2=0.69 to R2=0.75.
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