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- Godina, Christopher, et al.
(författare)
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Prognostic Impact of Menopausal Hormone Therapy in Breast Cancer Differs According to Tumor Characteristics and Treatment
- 2020
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002–2012) with follow-up until 2016. Associations between patient- and tumor characteristics, recurrences, and overall survival were analyzed in relation to MHT. After a median follow-up of 7 years, 119 recurrences, and 111 deaths occurred. Ever MHT (n = 433, 53.2%) was associated with a lower BMI, frequency of alcohol abstinence, and histological grade, higher frequency of oral contraceptive use, and lobular cancer. Overall, MHT was not associated with prognosis, but there were significant effect modifications by estrogen receptor (ER) status, node status, main histological type, and aromatase inhibitor (AI) treatment on recurrence-risk (all Pinteractions≤ 0.017). MHT conferred an increased recurrence-risk in patients with ER- tumors, adjusted Hazard Ratio (HRadj) 3.99 (95% Confidence Interval (CI) 1.40–11.33), in node-negative patients HRadj 1.88 (95% CI 1.11–3.17), and in non-AI-treated patients HRadj 1.81 (95% CI 1.01–3.24), but decreased recurrence-risk in AI-treated patients HRadj 0.46 (95% CI 0.25–0.84) and in patients with lobular cancer HRadj 0.15 (95% CI 0.04–0.64). MHT was associated with lower risk of death in node-positive patients HRadj of 0.48 (95% CI 0.27–0.86) and in AI-treated patients HRadj of 0.41 (95% CI 0.22–0.77), but not in other patients (both Pinteractions≤ 0.027). A history of MHT may have prognostic value for certain subgroups of breast cancer patients such as AI-treated or node-negative patients.
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| 3. |
- Ottander, Christina, 1962-, et al.
(författare)
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Didaktisk modellering för scientific literacy. SSI-inramning av kemilaboration om dricksvatten.
- 2021
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Ingår i: NFSUN 2021: Science Education in the light of Global Sustainable Development – Trends and possibilities.
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Konferensbidrag (refereegranskat)abstract
- Chemistry education needs to not only teach students about concepts, models and the nature and methods of science; science education also needs to prepare students to understand the role of chemistry in society. Teaching with socio-scientific issues has a promising approach, however, is also challenging for many teachers, as it involves changes in beliefs and values as well as the adoption of new practices despite limited resources and already overfull student curricula. To overcome these challenges, it is necessary to build on both experienced teachers’ knowledge and empirical research. This project utilizes teacher-researcher collaboration in three consecutive cycles to develop the teaching sequences and instructions, and to gain new knowledge about how science teachers identify challenges in laboratory teaching that focuses on SSIs; what the challenges are, and what strategies work to increase student achievement. One theme of identified challenges was the lack of continuity between different parts of the designed teaching sequence. The interactive research approach led to a collaborative work on formulation of explicit learning goals for both scientific methods and the consequences of investigation for individuals and society. Importantly, formulation of learning goals and written instructions helped in finding ways to link different parts of the teaching.
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