| 1. |
- Baldursdottír, Nina, 1986, et al.
(författare)
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Managing change through participation: Developing Shared Construction Guidelines in 26 public organisations
- 2012
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Ingår i: 28th Annual Conference of the Association of Researchers in Construction Management, ARCOM 2012; Edinburgh; United Kingdom; 3 September 2012 through 5 September 2012. - 9780955239069 ; 2, s. 863-873
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Konferensbidrag (refereegranskat)abstract
- Increasingly public sector clients are being asked to do more for less and are pushed to achieve higher levels of transparency and accountability. Thus, organisations' ability to address challenges like these has become increasingly important. As a result, a range of models have emerged to help organisations successfully manage this development. The research presented in this paper draws on an exploratory case study of an ongoing change process in the City of Gothenburg, where 26 municipal organisations are developing a shared process (Shared Construction Guidelines) for how to conduct building and infrastructure projects in the City. The aim is to describe this case of participatory change and to shed light on its complexities. Findings show that there is a high degree of commitment and participation in the case of Shared Construction Guidelines. However, there seems to be a gap between top management and the rest of the change organisation and resources are limited, especially in terms of time. Also, several findings indicate challenges regarding the understanding of the change. Altogether, this might explain why all members do not feel that they can fully affect the process, even though it is based on broad participation. Finally it is highlighted how the existing literature on change management falls short when describing complex participatory change processes.
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| 2. |
- Baldursdottír, Nina, 1986, et al.
(författare)
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Sensemaking of corporate cultural values
- 2011
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Ingår i: 6th Nordic Conference on Construction Economics and Organisation, Aahlborg 2011.
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Konferensbidrag (refereegranskat)
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| 3. |
- Benediktsdottir, Andrea, et al.
(författare)
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Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- New antibacterial compounds are urgently needed, especially for infections caused by the top-priority Gram-negative bacteria that are increasingly difficult to treat. Lipid A is a key component of the Gram-negative outer membrane and the LpxH enzyme plays an important role in its biosynthesis, making it an ideal antibacterial target. Inspired by previously reported ortho-N-methyl-sulfonamidobenzamide-based LpxH inhibitors, novel benzamide substitutions were explored in this work to assess their in vitro activity. Our findings reveal that maintaining wild-type antibacterial activity necessitates N-methyl removal when shifting the ortho-N-methyl-sulfonamide to the meta-position. This discovery led to the synthesis of meta-sulfonamidobenzamide analogs with potent antibacterial activity and enzyme inhibition. Moreover, we demonstrate that modifying the benzamide scaffold can alter hERG blocking. Furthermore, a LpxH-bound X-ray structure of the meta-sulfonamidobenzamide analog facilitated comparison with complexes with ortho-N-methyl-sulfonamidobenzamide analogs, and with the natural enzymatic reaction product lipid X, providing new insights into the enzyme-ligand interactions. Overall, our study has identified meta-sulfonamidobenzamide derivatives as promising LpxH-targeting hits with the potential for optimization in future antibacterial hit-to-lead programs.
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| 4. |
- Collin, Sven-Olof Yrjö, et al.
(författare)
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Governance strategy and costs : board compensation in Sweden
- 2017
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Ingår i: Journal of Management and Governance. - : Springer. - 1385-3457 .- 1572-963X. ; 21:3, s. 685-713
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Tidskriftsartikel (refereegranskat)abstract
- Shareholders are not identical, but differ in their objectives and actions. One difference is the level of delegation of the principal functions to the board, which we suggest can be observed through the level of directors’ compensation. We analyze the difference in board compensation through the concept of governance strategy and suggest two distinct categories of shareholder strategies: the company governance strategy and the financial governance strategy. These strategies create different distributions of governance costs, which we separate into principal costs and agency costs. We claim that the financial governance strategy adopts a higher level of delegation, which implies that the principal costs are assumed by the corporation and that agency costs are higher. This in turn can explain the higher compensation for the directors of the board compared to compensation under the company governance strategy. We test our hypothesis using a three-year panel of Swedish listed corporations and find that shareholders pursuing a financial governance strategy are associated with higher levels of board compensation. These findings suggest the existence of differences in governance strategies, reflected in governance costs through board compensation, among different types of shareholders in a corporation.
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| 5. |
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| 6. |
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| 7. |
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| 8. |
- Högberg, Peter, et al.
(författare)
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Large-scale forest girdling shows that current photosynthesis drives soil respiration
- 2001
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 411:6839, s. 789-792
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Tidskriftsartikel (refereegranskat)abstract
- The respiratory activities of plant roots, of their mycorrhizal fungi and of the free-living microbial heterotrophs (decomposers) in soils are significant components of the global carbon balance, but their relative contributions remain uncertain. To separate mycorrhizal root respiration from heterotrophic respiration in a boreal pine forest, we conducted a large-scale tree-girdling experiment, comprising 9 plots each containing about 120 trees. Tree-girdling involves stripping the stem bark to the depth of the current xylem at breast height terminating the supply of current photosynthates to roots and their mycorrhizal fungi without physically disturbing the delicate root-microbe-soil system. Here we report that girdling reduced soil respiration within 1-2 months by about 54% relative to respiration on ungirdled control plots, and that decreases of up to 37% were detected within 5 days. These values clearly show that the flux of current assimilates to roots is a key driver of soil respiration; they are conservative estimates of root respiration, however, because girdling increased the use of starch reserves in the roots. Our results indicate that models of soil respiration should incorporate measures of photosynthesis and of seasonal patterns of photosynthate allocation to roots.
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| 9. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 10. |
- Ottosson, Nina, et al.
(författare)
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A drug pocket at the lipid bilayer-potassium channel interface
- 2017
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Ingår i: Science Advances. - : AMER ASSOC ADVANCEMENT SCIENCE. - 2375-2548. ; 3:10
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Tidskriftsartikel (refereegranskat)abstract
- Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthesized and electrophysiologically tested 125 derivatives, analogs, and related compounds to dehydroabietic acid. Functional data in combination with docking and molecular dynamics simulations mapped a binding site for small-molecule compounds at the interface between the lipid bilayer and the transmembrane segments S3 and S4 of the voltage-sensor domain. This fundamentally new binding site for small-molecule compounds paves the way for the design of new types of drugs against diseases caused by altered excitability.
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