| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
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| 4. |
- Duygu, K., et al.
(författare)
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Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis
- 2021
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Ingår i: Acta Cardiologica. - : Informa UK Limited. - 0001-5385 .- 0373-7934. ; 76:5, s. 544-522
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Tidskriftsartikel (refereegranskat)abstract
- Background Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. Methods We consecutively recruited eligible subjects with moderate-severe CAS (n = 60), aortic sclerosis (ASc) (n = 49) and age and gender-matched control subjects (n = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Results Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all p > 0.05). CAS patients had higher plasma choline levels compared to both control (p < 0.001) and ASc (p = 0.006). Plasma betaine and TMAO levels were similar (both p > 0.05). Compared to the lowest quartile choline levels (<11.15 mu M), patients with the highest quartile choline levels (>= 14.98 mu M) had higher aortic valvular (p < 0.001) and mitral annular (p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B +/- SE:0.165 +/- 0.060, p = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (p < 0.001), neovascularization (p = 0.011), osseous metaplasia (p = 0.004), more severe tissue remodelling (p = 0.002) and calcification (p = 0.002). Conclusion We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
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| 5. |
- Efrati, S., et al.
(författare)
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Intrusion of coastal waters into the pelagic eastern Mediterranean : in situ and satellite-based characterization
- 2013
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Ingår i: Biogeosciences. - : Copernicus GmbH. - 1726-4170 .- 1726-4189. ; 10:5, s. 3349-3357
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Tidskriftsartikel (refereegranskat)abstract
- A combined dataset of near-real-time multi-satellite observations and in situ measurements from a high-resolution survey is used for characterizing physical-biogeochemical properties of a patch stretching from the coast to the open sea in the Levantine Basin (LB) of the eastern Mediterranean (EM). Spatial analysis of the combined dataset indicates that the patch is a semi-enclosed system, bounded within the mixed layer and separated from ambient waters by transport barriers induced by horizontal stirring. As such, the patch is characterized by physical-biogeochemical properties that significantly differ from those of the waters surrounding it, with lower salinity and higher temperatures, concentrations of silicic acid and chlorophyll a, and abundance of Synechococcus and picoeukaryote cells. Based on estimates of patch dimensions (similar to 40 km width and similar to 25m depth) and propagation speed (similar to 0.09ms(-1)), the volume flux associated with the patch is found to be on the order of 0.1 Sv. Our observations suggest that horizontal stirring by surface currents is likely to have an important impact on the ultra-oligotrophic Levantine Basin ecosystem, through (1) transport of nutrients and coastally derived material, and (2) formation of local, dynamically isolated niches. In addition, this work provides a satellite-based framework for planning and executing high-resolution sampling strategies in the interface between the coast and the open sea.
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| 6. |
- Kocyigit, D., et al.
(författare)
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Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis
- 2021
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Ingår i: Atherosclerosis Plus. - : Elsevier BV. - 2667-0909 .- 2667-0895. ; 44:October, s. 18-24
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Cholesterol efflux capacity is a functional property of high-density lipoproteins (HDL) reflecting the efficiency of the atheroprotective reverse cholesterol transport process in humans. Its relationship with calcific aortic valve stenosis (CAVS) has not been fully assessed yet. Methods: We evaluated HDL-CEC in a patient population with varying degrees of aortic valvular calcific disease, assessed using echocardiography and cardiac computed tomography. Measurement of biomarkers that reflect osteogenic and tissue remodeling, along with dietary and gut microbiota-derived metabolites were performed. Results: Patients with moderate-severe CAVS had significantly lower HDL-CEC compared to both control and aortic sclerosis subjects (mean: 6.09%, 7.32% and 7.26%, respectively). HDL-CEC displayed negative correlations with peak aortic jet velocity and aortic valve calcium score, indexes of CAVS severity (ρ = -0.298, p = 0.002 and ρ = -0.358, p = 0.005, respectively). In multivariable regression model, HDL-CEC had independent association with aortic valve calcium score (B: -0.053, SE: 0.014, p < 0.001), GFR (B: -0.034, SE: 0.012, p = 0.007), as well as with levels of total cholesterol (B: 0.018, SE: 0.005, p = 0.002). Conclusion: These results indicate an impairment of HDL-CEC in moderate-severe CAVS and may contribute to identify potential novel targets for CAVS management. © 2021 The Authors
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| 7. |
- Koptekin, Dilek, et al.
(författare)
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Spatial and temporal heterogeneity in human mobility patterns in Holocene Southwest Asia and the East Mediterranean
- 2023
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Ingår i: Current Biology. - : Cell Press. - 0960-9822 .- 1879-0445. ; 33:1, s. 41-57
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Tidskriftsartikel (refereegranskat)abstract
- We present a spatiotemporal picture of human genetic diversity in Anatolia, Iran, Levant, South Caucasus, and the Aegean, a broad region that experienced the earliest Neolithic transition and the emergence of com-plex hierarchical societies. Combining 35 new ancient shotgun genomes with 382 ancient and 23 present-day published genomes, we found that genetic diversity within each region steadily increased through the Holo-cene. We further observed that the inferred sources of gene flow shifted in time. In the first half of the Holo-cene, Southwest Asian and the East Mediterranean populations homogenized among themselves. Starting with the Bronze Age, however, regional populations diverged from each other, most likely driven by gene flow from external sources, which we term "the expanding mobility model."Interestingly, this increase in in-ter-regional divergence can be captured by outgroup-f3-based genetic distances, but not by the commonly used FST statistic, due to the sensitivity of FST, but not outgroup-f3, to within-population diversity. Finally, we report a temporal trend of increasing male bias in admixture events through the Holocene.
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| 8. |
- Mendonca, Luciana De Michelis, et al.
(författare)
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Sports injury prevention programmes from the sports physical therapists perspective: An international expert Delphi approach
- 2022
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Ingår i: Physical Therapy in Sport. - Oxford, United Kingdom : Elsevier. - 1466-853X .- 1873-1600. ; 55, s. 146-154
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To provide consensus on how to plan, organize and implement exercise-based injury prevention program (IPP) in sports.Design: Delphi.Setting: LimeSurvey platform.Participants: Experienced sports physical therapists from the International Federation of Sports Physical Therapy member countries.Main outcome measures: Factors related to sports IPP planning, organization and implementation.Results: We included 305 participants from 32 countries. IPP planning should be based on an athletes injury history, on pre-season screening results, and on injury rates (respectively, 98%, 92%, 89% agreement). In total 97% participants agreed that IPP organization should depend on the athletes age, 93% on the competition level, and 93% on the availability of low-cost materials. It was agreed that IPP should mainly be implemented in warm-up sessions delivered by the head or strength/conditioning coach, with physical training sessions and individual physical therapy sessions (respectively, 94%, 92%, 90% agreement).Conclusion: Strong consensus was reached on (1) IPP based on the athletes injury history, pre-season screening and evidence-based sports-specific injury rates; (2) IPP organization based on the athletes age, competition level, and the availability of low-cost materials and (3) IPP implementation focussing on warm-up sessions implemented by the strength/conditioning coach, and/or individual prevention sessions by the physical therapist.
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