| 1. |
- Aleman, Alexandru, et al.
(författare)
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Harmonic maps and shift-invariant subspaces
- 2021
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Ingår i: Monatshefte fur Mathematik. - : Springer Science and Business Media LLC. - 0026-9255 .- 1436-5081. ; 194:4, s. 625-656
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Tidskriftsartikel (refereegranskat)abstract
- With the help of operator-theoretic methods, we derive new and powerful criteria for finiteness of the uniton number for a harmonic map from a Riemann surface to the unitary group U(n). These use the Grassmannian model where harmonic maps are represented by families of shift-invariant subspaces of L2(S1, Cn) ; we give a new description of that model.
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| 2. |
- Aleman, Alexandru, et al.
(författare)
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Symmetric shift-invariant subspaces and harmonic maps
- 2021
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Ingår i: Mathematische Zeitschrift. - : Springer Science and Business Media LLC. - 0025-5874 .- 1432-1823. ; 299:1-2, s. 183-202
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Tidskriftsartikel (refereegranskat)abstract
- The Grassmannian model represents harmonic maps from Riemann surfaces by families of shift-invariant subspaces of a Hilbert space. We impose a natural symmetry condition on the shift-invariant subspaces that corresponds to considering an important class of harmonic maps into symmetric and k-symmetric spaces. Using an appropriate description of such symmetric shift-invariant subspaces we obtain new results for the corresponding extended solutions, including how to obtain primitive harmonic maps from certain harmonic maps into the unitary group.
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| 3. |
- Bogas, Diana, et al.
(författare)
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Applications of optical DNA mapping in microbiology
- 2017
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Ingår i: BioTechniques. - : Future Science Ltd. - 0736-6205 .- 1940-9818. ; 62:6, s. 255-267
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Forskningsöversikt (refereegranskat)abstract
- Optical mapping (OM) has been used in microbiology for the past 20 years, initially as a technique to facilitate DNA sequence-based studies; however, with decreases in DNA sequencing costs and increases in sequence output from automated sequencing platforms, OM has grown into an important auxiliary tool for genome assembly and comparison. Currently, there are a number of new and exciting applications for OM in the field of microbiology, including investigation of disease outbreaks, identification of specific genes of clinical and/or epidemiological relevance, and the possibility of single-cell analysis when combined with cell-sorting approaches. In addition, designing lab-on-a-chip systems based on OM is now feasible and will allow the integrated and automated microbiological analysis of biological fluids. Here, we review the basic technology of OM, detail the current state of the art of the field, and look ahead to possible future developments in OM technology for microbiological applications.
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| 4. |
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| 5. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 6. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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