| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
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| 4. |
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| 5. |
- Nilsson, C. L., et al.
(författare)
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Use of ENCODE Resources to Characterize Novel Proteoforms and Missing Proteins in the Human Proteome
- 2015
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 14:2, s. 603-608
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Tidskriftsartikel (refereegranskat)abstract
- We describe the utility of integrated strategies that employ both translation of ENCODE data and major proteomic technology pillars to improve the identification of the "missing proteins", novel proteoforms, and PTMs. On one hand, databases in combination with bioinformatic tools are efficiently utilized to establish microarray-based transcript analysis and supply rapid protein identifications in clinical samples. On the other hand, sequence libraries are the foundation of targeted protein identification and quantification using mass spectrometric and immunoaffinity techniques. The results from combining proteoENCODEdb searches with experimental mass spectral data indicate that some alternative splicing forms detected at the transcript level are in fact translated to proteins. Our results provide a step toward the directives of the C-HPP initiative and related biomedical research.
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| 6. |
- Lee, J. -H, et al.
(författare)
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Comparative study on added resistance of a bulk carrier in regular head and oblique waves
- 2020
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Ingår i: Proceedings of the International Offshore and Polar Engineering Conference. - : International Society of Offshore and Polar Engineers. - 9781880653845 ; , s. 3385-3393
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Konferensbidrag (refereegranskat)abstract
- In this study, a comparative study on motion response and added resistance of a Supramax bulk carrier (K-Supramax Original) in regular waves was carried out to evaluate the reliabilities and accuracies of experimental and numerical simulation techniques. Two kinds of experiments were performed; one is the towing tank model testing for head wave conditions conducted at Seoul National University, and the other is the free-running model test for head and oblique wave conditions conducted at SSPA Sweden AB. Also, nine numerical computation results submitted by seven institutions were compared with the experimental data. The computation results were obtained by various seakeeping analysis methods such as the 2D strip theory, 3D Rankine panel method, and Computational Fluid Dynamics (CFD) based analysis. Based on the comparison, the characteristics of each numerical technique and resultant accuracies of seakeeping analyses were investigated. It was also confirmed that different results were obtained although the same program was used because of the user dependencies; setting for computation parameters, numerical schemes, and mesh generations, etc. Furthermore, the sensitivities of seakeeping quantities with respect to wave amplitudes were examined by conducting both model tests and nonlinear numerical simulations for different wave slopes. Lastly, the tendencies of ship motion and added resistance depending on the heading angle were identified, and the reliabilities of experiments and numerical computations for oblique waves were discussed.
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| 7. |
- Omenn, G. S., et al.
(författare)
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Progress on Identifying and Characterizing the Human Proteome : 2019 Metrics from the HUPO Human Proteome Project
- 2019
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Ingår i: Journal of Proteome Research. - : American Chemical Society. - 1535-3893 .- 1535-3907. ; 18:12, s. 4098-4107
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Tidskriftsartikel (refereegranskat)abstract
- The Human Proteome Project (HPP) annually reports on progress made throughout the field in credibly identifying and characterizing the complete human protein parts list and making proteomics an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2019-01-11 contains 17 694 proteins with strong protein-level evidence (PE1), compliant with HPP Guidelines for Interpretation of MS Data v2.1; these represent 89% of all 19 823 neXtProt predicted coding genes (all PE1,2,3,4 proteins), up from 17 470 one year earlier. Conversely, the number of neXtProt PE2,3,4 proteins, termed the "missing proteins" (MPs), has been reduced from 2949 to 2129 since 2016 through efforts throughout the community, including the chromosome-centric HPP. PeptideAtlas is the source of uniformly reanalyzed raw mass spectrometry data for neXtProt; PeptideAtlas added 495 canonical proteins between 2018 and 2019, especially from studies designed to detect hard-to-identify proteins. Meanwhile, the Human Protein Atlas has released version 18.1 with immunohistochemical evidence of expression of 17 000 proteins and survival plots as part of the Pathology Atlas. Many investigators apply multiplexed SRM-targeted proteomics for quantitation of organ-specific popular proteins in studies of various human diseases. The 19 teams of the Biology and Disease-driven B/D-HPP published a total of 160 publications in 2018, bringing proteomics to a broad array of biomedical research.
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