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1.	Kattge, Jens, et al. (författare) TRY plant trait database - enhanced coverage and open access 2020 Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188 Tidskriftsartikel (refereegranskat)abstract Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
2.	Palacios, Sean D., et al. (författare) Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media 2002 Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 186:12, s. 1761-9 Tidskriftsartikel (refereegranskat)abstract Hyperplasia of middle-ear mucosa (MEM) during otitis media (OM) is thought to be partially mediated by the actions of growth factors and their receptors. The intracellular pathway leading from the small G-protein Ras to the extracellular regulated kinases (Erks) often links growth factor stimulation to cellular proliferation. This study assessed whether this pathway is involved in MEM hyperplasia during bacterial OM via the activation of Erk1/Erk2 in MEM of an in vivo rat bacterial OM model. Activation was maximal at 1 and 6 h and at 1 week after introduction of bacteria into the middle ear. Additionally, an in vitro model of rat MEM in bacterial OM was treated with farnesyl transferase inhibitor 277 or the Mek inhibitor U0126. MEM explants treated with either inhibitor demonstrated significant suppression of bacterially induced growth. These data support a role for Ras and Erk signaling in MEM hyperplasia during bacterial OM.
3.	Palacios, Sean D., et al. (författare) Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media 2004 Ingår i: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 72:8, s. 4662-7 Tidskriftsartikel (refereegranskat)abstract Hyperplasia of the middle ear mucosa contributes to the sequelae of acute otitis media. Understanding the signal transduction pathways that mediate hyperplasia could lead to the development of new therapeutic interventions for this disease and its sequelae. Endotoxin derived from bacteria involved in middle ear infection can contribute to the hyperplastic response. The p38 mitogen-activated protein kinase (MAPK) is known to be activated by endotoxin as well as cytokines and other inflammatory mediators that have been documented in otitis media. We assessed the activation of p38 in the middle ear mucosa of an in vivo rat bacterial otitis media model. Strong activity of p38 was observed 1 to 6 h after bacterial inoculation. Activity continued at a lower level for at least 7 days. The effects of p38 activation were assessed using an in vitro model of rat middle ear mucosal hyperplasia in which mucosal growth is stimulated by nontypeable Haemophilus influenzae during acute otitis media. Hyperplastic mucosal explants treated with the p38 alpha and p38 beta inhibitor SB203580 demonstrated significant inhibition of otitis media-stimulated mucosal growth. The results of this study suggest that intracellular signaling via p38 MAPK influences the hyperplastic response of the middle ear mucosa during bacterial otitis media.

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Författare/redaktör: Melhus, Åsa (2); Diaz, Sandra (1); Ostonen, Ivika (1); Tedersoo, Leho (1); Bond-Lamberty, Ben (1); Moretti, Marco (1); visa fler...; Wang, Feng (1); Verheyen, Kris (1); Graae, Bente Jessen (1); Isaac, Marney (1); Lewis, Simon L. (1); Zieminska, Kasia (1); Phillips, Oliver L. (1); Jackson, Robert B. (1); Reichstein, Markus (1); Hickler, Thomas (1); Rogers, Alistair (1); Manzoni, Stefano (1); Pakeman, Robin J. (1); Poschlod, Peter (1); Dainese, Matteo (1); Ruiz-Peinado, Ricard ... (1); van Bodegom, Peter M ... (1); Wellstein, Camilla (1); Gross, Nicolas (1); Violle, Cyrille (1); Björkman, Anne, 1981 (1); Rillig, Matthias C. (1); Tappeiner, Ulrike (1); MARQUES, MARCIA (1); Jactel, Hervé (1); Castagneyrol, Bastie ... (1); Scherer-Lorenzen, Mi ... (1); van der Plas, Fons (1); Cromsigt, Joris (1); Jenkins, Thomas (1); Boeckx, Pascal (1); Estiarte, Marc (1); Jentsch, Anke (1); Peñuelas, Josep (1); Reich, Peter B (1); Le Roux, Peter C. (1); Baker, William J. (1); Onstein, Renske E. (1); Barlow, Jos (1); Berenguer, Erika (1); Vamosi, Jana (1); Niinemets, Ulo (1); Tjoelker, Mark G (1); Harrison, Sandy P. (1); visa färre...

Lärosäte: Uppsala universitet (2); Lunds universitet (2); Göteborgs universitet (1); Stockholms universitet (1); Karlstads universitet (1); Sveriges Lantbruksuniversitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2); Naturvetenskap (1)

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