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Sökning: WFRF:(Palm Wilhelm)

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1.
  • Chio, Iok In Christine, et al. (författare)
  • NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
  • 2016
  • Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 166:4, s. 936-976
  • Tidskriftsartikel (refereegranskat)abstract
    • Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer initiation. Here, we show that NRF2 is necessary to maintain pancreatic cancer proliferation by regulating mRNA translation. Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signaling and oxidation of specific translational regulatory proteins, resulting in impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells. Combined targeting of the EGFR effector AKT and the glutathione antioxidant pathway mimicked Nrf2 ablation to potently inhibit pancreatic cancer ex vivo and in vivo, representing a promising synthetic lethal strategy for treating the disease.
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2.
  • Staron, Miroslaw, 1977, et al. (författare)
  • Release Readiness Indicator for Mature Agile and Lean Software Development Projects
  • 2012
  • Ingår i: Lecture Notes in Business Information Processing. ; 111:3, s. 93-107
  • Konferensbidrag (refereegranskat)abstract
    • Large companies like Ericsson increasingly often adopt the principles of Agile and Lean software development and develop large software products in iterative manner – in order to quickly respond to customer needs. In this paper we present the main indicator which is sufficient for a mature software development organization in order to predict the time in weeks to release the product. In our research project we collaborated closely with a large Agile+Lean software development project at Ericsson in Sweden. This large and mature software development project and organization has found this main indicator – release readiness – to be so important that it was used as a key performance indicator and is used in controlling the development of the product and improving organizational performance. The indicator was developed and validated in an action research project at one of the units of Ericsson AB in Sweden in one of its largest projects.
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