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- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 2. |
- Vaivads, Andris, et al.
(författare)
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Turbulence Heating ObserveR - satellite mission proposal
- 2016
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Ingår i: JOURNAL OF PLASMA PHYSICS. - 0022-3778. ; 82
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Tidskriftsartikel (refereegranskat)abstract
- The Universe is permeated by hot, turbulent, magnetized plasmas. Turbulent plasma is a major constituent of active galactic nuclei, supernova remnants, the intergalactic and interstellar medium, the solar corona, the solar wind and the Earth's magnetosphere, just to mention a few examples. Energy dissipation of turbulent fluctuations plays a key role in plasma heating and energization, yet we still do not understand the underlying physical mechanisms involved. THOR is a mission designed to answer the questions of how turbulent plasma is heated and particles accelerated, how the dissipated energy is partitioned and how dissipation operates in different regimes of turbulence. THOR is a single-spacecraft mission with an orbit tuned to maximize data return from regions in near-Earth space - magnetosheath, shock, foreshock and pristine solar wind - featuring different kinds of turbulence. Here we summarize the THOR proposal submitted on 15 January 2015 to the 'Call for a Medium-size mission opportunity in ESAs Science Programme for a launch in 2025 (M4)'. THOR has been selected by European Space Agency (ESA) for the study phase.
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| 6. |
- Lehtinen, M, et al.
(författare)
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Ten-year follow-up of human papillomavirus vaccine efficacy against the most stringent cervical neoplasia end-point-registry-based follow-up of three cohorts from randomized trials
- 2017
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 7:8, s. e015867-
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Tidskriftsartikel (refereegranskat)abstract
- Due to long lag time between infection/cancer diagnoses human papillomavirus (HPV) vaccination programs will deliver vaccine efficacy (VE) estimates against cancer end-points late. Cancer registry follow-up of population-based, randomised trial cohorts of vaccinated and unvaccinated women was undertaken for the estimation of VE against cervical intraepithelial neoplasia grade three and invasive cancer (CIN3+).MethodsWe report interim results with 98 561 person years of Finnish Cancer Registry -based follow-up of individually and/or cluster randomised cohorts of HPV-16/18 vaccinated and unvaccinated adolescent women enrolled in June 2003/2005, and between May 2004 and April 2005, respectively. The cohorts comprised 15 627 18- to 19-year-old unvaccinated women (NCT01393470), and 2 401 and 64 16- to 17-year-old HPV-16/18 vaccinated women participating the PATRICIA (NCT00122681) and HPV-012 (NCT00169494) trials, respectively. The age-aligned passive follow-up started 6 months after the clinical trials’ end.ResultsDuring the follow-up of 4.5 to 10 years post enrolment we identified 75 cases of cervical intraepithelial neoplasia grade 3 (CIN3) and 4 cases of invasive cervical cancer (ICC) in the unvaccinated cohort, and 4 CIN3 cases in the HPV-16/18 vaccinated women. Diagnostic blocks were available for HPV typing from 87% of the cases. CIN3+ lesions were detectable in 54 cases. HPV16 was found in 26 of 50 unvaccinated CIN3+ cases, and in 3 CIN3+ cases in the HPV-16/18 vaccinated women. The latter were all baseline positive for cervical HPV16 DNA. Baseline data was not available for the unvaccinated women. Intention-to-treat VE against any CIN3+ was 66% (95% CI 8, 88).ConclusionsTen years post vaccination the AS04-adjuvanted HPV-16/18 vaccine shows continued efficacy against CIN3+ irrespectively of HPV type. Vaccine efficacy was not observed in baseline HPV16 DNA positive subjects.Trial registration numberNCT01393470.
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| 7. |
- Branduardi-Raymont, G., et al.
(författare)
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Exploring solar-terrestrial interactions via multiple imaging observers
- 2022
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Ingår i: Experimental astronomy. - : Springer Nature. - 0922-6435 .- 1572-9508. ; 54:2-3, s. 361-390
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Tidskriftsartikel (refereegranskat)abstract
- How does solar wind energy flow through the Earth's magnetosphere, how is it converted and distributed? is the question we want to address. We need to understand how geomagnetic storms and substorms start and grow, not just as a matter of scientific curiosity, but to address a clear and pressing practical problem: space weather, which can influence the performance and reliability of our technological systems, in space and on the ground, and can endanger human life and health. Much knowledge has already been acquired over the past decades, particularly by making use of multiple spacecraft measuring conditions in situ, but the infant stage of space weather forecasting demonstrates that we still have a vast amount of learning to do. A novel global approach is now being taken by a number of space imaging missions which are under development and the first tantalising results of their exploration will be available in the next decade. In this White Paper, submitted to ESA in response to the Voyage 2050 Call, we propose the next step in the quest for a complete understanding of how the Sun controls the Earth's plasma environment: a tomographic imaging approach comprising two spacecraft in highly inclined polar orbits, enabling global imaging of magnetopause and cusps in soft X-rays, of auroral regions in FUV, of plasmasphere and ring current in EUV and ENA (Energetic Neutral Atoms), alongside in situ measurements. Such a mission, encompassing the variety of physical processes determining the conditions of geospace, will be crucial on the way to achieving scientific closure on the question of solar-terrestrial interactions.
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| 8. |
- Fryer, L. J., et al.
(författare)
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3D GUMICS Simulations of Northward IMF Magnetotail Structure
- 2023
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 128:8
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Tidskriftsartikel (refereegranskat)abstract
- This study presents a re-evaluation of the Kullen and Janhunen (2004, https://doi.org/10.5194/angeo-22-951-2004) global northward interplanetary magnetic field (IMF) simulation, using the Grand Unified Magnetosphere–Ionosphere Coupling Simulation version 4 (GUMICS-4), a global MHD model. We investigate the dynamic coupling between northward IMF conditions and the Earth’s magnetotail and compare the results to observation-based mechanisms for the formation of transpolar arcs. The results of this study reveal that under northward IMF conditions (and northward IMF initialization), a large closed field line region forms in the magnetotail, with similarities to transpolar arc structures observed from spacecraft data. This interpretation is supported by the simultaneous increase of closed flux measured in the magnetotail. However, the reconnection configuration differs in several respects from previously theorized magnetotail structures that have been inferred from both observations and simulations results and associated with transpolar arcs. We observe that dawn–dusk lobe regions form as a result of high-latitude reconnection during the initialization stages, which later come into contact as the change in the IMF By component causes the magnetotail to twist. We conclude that in the GUMICS simulation, transpolar arc-like structures are formed as a result of reconnection in the magnetotail, rather than high-latitude reconnection or due to the mapping of the plasma sheet through a twisted magnetotail as interpreted from previous analysis of GUMICS simulations.
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| 9. |
- George, H., et al.
(författare)
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Estimating Inner Magnetospheric Radial Diffusion Using a Hybrid-Vlasov Simulation
- 2022
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Ingår i: Frontiers in Astronomy and Space Sciences. - : Frontiers Media S.A.. - 2296-987X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Radial diffusion coefficients quantify non-adiabatic transport of energetic particles by electromagnetic field fluctuations in planetary radiation belts. Theoretically, radial diffusion occurs for an ensemble of particles that experience irreversible violation of their third adiabatic invariant, which is equivalent to a change in their Roederer L* parameter. Thus, the Roederer L* coordinate is the fundamental quantity from which radial diffusion coefficients can be computed. In this study, we present a methodology to calculate the Lagrangian derivative of L* from global magnetospheric simulations, and test it with an application to Vlasiator, a hybrid-Vlasov model of near-Earth space. We use a Hamiltonian formalism for particles confined to closed drift shells with conserved first and second adiabatic invariants to compute changes in the guiding center drift paths due to electric and magnetic field fluctuations. We investigate the feasibility of this methodology by computing the time derivative of L* for an equatorial ultrarelativistic electron population travelling along four guiding center drift paths in the outer radiation belt during a 5 minute portion of a Vlasiator simulation. Radial diffusion in this simulation is primarily driven by ultralow frequency waves in the Pc3 range (10-45 s period range) that are generated in the foreshock and transmitted through the magnetopause to the outer radiation belt environment. Our results show that an alternative methodology to compute detailed radial diffusion transport is now available and could form the basis for comparison studies between numerical and observational measurements of radial transport in the Earth's radiation belts.
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