| 1. |
- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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| 2. |
- George, H., et al.
(författare)
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Estimating Inner Magnetospheric Radial Diffusion Using a Hybrid-Vlasov Simulation
- 2022
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Ingår i: Frontiers in Astronomy and Space Sciences. - : Frontiers Media S.A.. - 2296-987X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Radial diffusion coefficients quantify non-adiabatic transport of energetic particles by electromagnetic field fluctuations in planetary radiation belts. Theoretically, radial diffusion occurs for an ensemble of particles that experience irreversible violation of their third adiabatic invariant, which is equivalent to a change in their Roederer L* parameter. Thus, the Roederer L* coordinate is the fundamental quantity from which radial diffusion coefficients can be computed. In this study, we present a methodology to calculate the Lagrangian derivative of L* from global magnetospheric simulations, and test it with an application to Vlasiator, a hybrid-Vlasov model of near-Earth space. We use a Hamiltonian formalism for particles confined to closed drift shells with conserved first and second adiabatic invariants to compute changes in the guiding center drift paths due to electric and magnetic field fluctuations. We investigate the feasibility of this methodology by computing the time derivative of L* for an equatorial ultrarelativistic electron population travelling along four guiding center drift paths in the outer radiation belt during a 5 minute portion of a Vlasiator simulation. Radial diffusion in this simulation is primarily driven by ultralow frequency waves in the Pc3 range (10-45 s period range) that are generated in the foreshock and transmitted through the magnetopause to the outer radiation belt environment. Our results show that an alternative methodology to compute detailed radial diffusion transport is now available and could form the basis for comparison studies between numerical and observational measurements of radial transport in the Earth's radiation belts.
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| 3. |
- Branduardi-Raymont, G., et al.
(författare)
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Exploring solar-terrestrial interactions via multiple imaging observers
- 2022
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Ingår i: Experimental astronomy. - : Springer Nature. - 0922-6435 .- 1572-9508. ; 54:2-3, s. 361-390
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Tidskriftsartikel (refereegranskat)abstract
- How does solar wind energy flow through the Earth's magnetosphere, how is it converted and distributed? is the question we want to address. We need to understand how geomagnetic storms and substorms start and grow, not just as a matter of scientific curiosity, but to address a clear and pressing practical problem: space weather, which can influence the performance and reliability of our technological systems, in space and on the ground, and can endanger human life and health. Much knowledge has already been acquired over the past decades, particularly by making use of multiple spacecraft measuring conditions in situ, but the infant stage of space weather forecasting demonstrates that we still have a vast amount of learning to do. A novel global approach is now being taken by a number of space imaging missions which are under development and the first tantalising results of their exploration will be available in the next decade. In this White Paper, submitted to ESA in response to the Voyage 2050 Call, we propose the next step in the quest for a complete understanding of how the Sun controls the Earth's plasma environment: a tomographic imaging approach comprising two spacecraft in highly inclined polar orbits, enabling global imaging of magnetopause and cusps in soft X-rays, of auroral regions in FUV, of plasmasphere and ring current in EUV and ENA (Energetic Neutral Atoms), alongside in situ measurements. Such a mission, encompassing the variety of physical processes determining the conditions of geospace, will be crucial on the way to achieving scientific closure on the question of solar-terrestrial interactions.
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| 4. |
- Alho, M., et al.
(författare)
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Electron Signatures of Reconnection in a Global eVlasiator Simulation
- 2022
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 49:14
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Tidskriftsartikel (refereegranskat)abstract
- Geospace plasma simulations have progressed toward more realistic descriptions of the solar wind-magnetosphere interaction from magnetohydrodynamic to hybrid ion-kinetic, such as the state-of-the-art Vlasiator model. Despite computational advances, electron scales have been out of reach in a global setting. eVlasiator, a novel Vlasiator submodule, shows for the first time how electromagnetic fields driven by global hybrid-ion kinetics influence electrons, resulting in kinetic signatures. We analyze simulated electron distributions associated with reconnection sites and compare them with Magnetospheric Multiscale (MMS) spacecraft observations. Comparison with MMS shows that key electron features, such as reconnection inflows, heated outflows, flat-top distributions, and bidirectional streaming, are in remarkable agreement. Thus, we show that many reconnection-related features can be reproduced despite strongly truncated electron physics and an ion-scale spatial resolution. Ion-scale dynamics and ion-driven magnetic fields are shown to be significantly responsible for the environment that produces electron dynamics observed by spacecraft in near-Earth plasmas.
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| 5. |
- Dubart, M., et al.
(författare)
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Sub-grid modeling of pitch-angle diffusion for ion-scale waves in hybrid-Vlasov simulations with Cartesian velocity space
- 2022
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Ingår i: Physics of Plasmas. - : American Institute of Physics (AIP). - 1070-664X .- 1089-7674. ; 29:10
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Tidskriftsartikel (refereegranskat)abstract
- Numerical simulations have grown to play a central role in modern sciences over the years. The ever-improving technology of supercomputers has made large and precise models available. However, this accuracy is often limited by the cost of computational resources. Lowering the simulation's spatial resolution in order to conserve resources can lead to key processes being unresolved. We have shown in a previous study how insufficient spatial resolution of the proton cyclotron instability leads to a misrepresentation of ion dynamics in hybrid-Vlasov simulations. This leads to larger than expected temperature anisotropy and loss-cone shaped velocity distribution functions. In this study, we present a sub-grid numerical model to introduce pitch-angle diffusion in a 3D Cartesian velocity space, at a spatial resolution where the relevant wave-particle interactions were previously not correctly resolved. We show that the method is successfully able to isotropize loss-cone shaped velocity distribution functions, and that this method could be applied to simulations in order to save computational resources and still correctly model wave-particle interactions.
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| 6. |
- Suni, J., et al.
(författare)
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Connection Between Foreshock Structures and the Generation of Magnetosheath Jets : Vlasiator Results
- 2021
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 48:20
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Tidskriftsartikel (refereegranskat)abstract
- Earth's magnetosheath consists of shocked solar wind plasma that has been compressed and slowed down at the Earth's bow shock. Magnetosheath jets are pulses of enhanced dynamic pressure in the magnetosheath. Jets have been observed by numerous spacecraft missions, but their origin has remained unconfirmed, though several formation mechanisms have been suggested. In this study, we use a method for automatically identifying and tracking jets as well as foreshock compressive structures (FCSs) in four 2D runs of the global hybrid-Vlasov simulation Vlasiator. We find that up to 75% of magnetosheath jets are caused by FCSs impacting the bow shock. These jets propagate deeper into the magnetosheath than the remaining 25% of jets that are not caused by FCSs. We conduct a visual case study of one jet that was not caused by FCSs and find that the bow shock was not rippled before the formation of the jet. Plain Language Summary The space around Earth is filled with plasma, the fourth state of matter. Earth's magnetic field shields our planet from the stream of plasma coming from the Sun, the solar wind. The solar wind plasma is slowed down at the Earth's bow shock, before it flows against and around the Earth's magnetic field in the magnetosheath. Sometimes, pulses of high density or velocity can occur in the magnetosheath that have the potential to disturb the inner regions of near-Earth space where many spacecraft orbit. We call these pulses magnetosheath jets. Magnetosheath jets have been observed by many spacecraft over the past few decades, but how they form has remained unclear. In this study, we use the Vlasiator model to simulate plasma in near-Earth space and investigate the origins of magnetosheath jets. We find that the formation of up to 75% of these jets can be explained by compressive structures in the foreshock, a region populated by intense wave activity extending sunward of the quasi-parallel bow shock, where interplanetary magnetic field lines allow shock-reflected particles to travel back toward the Sun. Key Points We investigated magnetosheath jets in four hybrid-Vlasov simulation runs with different solar wind parameters Foreshock compressive structures can explain the formation of up to 75% of magnetosheath jets The foreshock compressive structure-caused jets travel deeper into the magnetosheath than the 25% of the jets whose origins remain unclear
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| 7. |
- Vaivads, Andris, et al.
(författare)
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Turbulence Heating ObserveR - satellite mission proposal
- 2016
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Ingår i: JOURNAL OF PLASMA PHYSICS. - 0022-3778. ; 82
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Tidskriftsartikel (refereegranskat)abstract
- The Universe is permeated by hot, turbulent, magnetized plasmas. Turbulent plasma is a major constituent of active galactic nuclei, supernova remnants, the intergalactic and interstellar medium, the solar corona, the solar wind and the Earth's magnetosphere, just to mention a few examples. Energy dissipation of turbulent fluctuations plays a key role in plasma heating and energization, yet we still do not understand the underlying physical mechanisms involved. THOR is a mission designed to answer the questions of how turbulent plasma is heated and particles accelerated, how the dissipated energy is partitioned and how dissipation operates in different regimes of turbulence. THOR is a single-spacecraft mission with an orbit tuned to maximize data return from regions in near-Earth space - magnetosheath, shock, foreshock and pristine solar wind - featuring different kinds of turbulence. Here we summarize the THOR proposal submitted on 15 January 2015 to the 'Call for a Medium-size mission opportunity in ESAs Science Programme for a launch in 2025 (M4)'. THOR has been selected by European Space Agency (ESA) for the study phase.
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| 8. |
- Johlander, Andreas, 1990-, et al.
(författare)
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Ion Acceleration Efficiency at the Earth's Bow Shock : Observations and Simulation Results
- 2021
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 914:2
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Tidskriftsartikel (refereegranskat)abstract
- Collisionless shocks are some of the most efficient particle accelerators in heliospheric and astrophysical plasmas. Here we study and quantify ion acceleration at Earth's bow shock with observations from NASA's Magnetospheric Multiscale (MMS) satellites and in a global hybrid-Vlasov simulation. From the MMS observations, we find that quasiparallel shocks are more efficient at accelerating ions. There, up to 15% of the available energy goes into accelerating ions above 10 times their initial energy. Above a shock-normal angle of similar to 50 degrees, essentially no energetic ions are observed downstream of the shock. We find that ion acceleration efficiency is significantly lower when the shock has a low Mach number (M ( A ) < 6) while there is little Mach number dependence for higher values. We also find that ion acceleration is lower on the flanks of the bow shock than at the subsolar point regardless of the Mach number. The observations show that a higher connection time of an upstream field line leads to somewhat higher acceleration efficiency. To complement the observations, we perform a global hybrid-Vlasov simulation with realistic solar-wind parameters with the shape and size of the bow shock. We find that the ion acceleration efficiency in the simulation shows good quantitative agreement with the MMS observations. With the combined approach of direct spacecraft observations, we quantify ion acceleration in a wide range of shock angles and Mach numbers.
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| 9. |
- Kilpua, E. K. J., et al.
(författare)
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Solar Wind Properties and Geospace Impact of Coronal Mass Ejection-Driven Sheath Regions : Variation and Driver Dependence
- 2019
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Ingår i: Space Weather. - 1542-7390. ; 17:8, s. 1257-1280
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Tidskriftsartikel (refereegranskat)abstract
- We present a statistical study of interplanetary conditions and geospace response to 89 coronal mass ejection-driven sheaths observed during Solar Cycles 23 and 24. We investigate in particular the dependencies on the driver properties and variations across the sheath. We find that the ejecta speed principally controls the sheath geoeffectiveness and shows the highest correlations with sheath parameters, in particular in the region closest to the shock. Sheaths of fast ejecta have on average high solar wind speeds, magnetic (B) field magnitudes, and fluctuations, and they generate efficiently strong out-of-ecliptic fields. Slow-ejecta sheaths are considerably slower and have weaker fields and field fluctuations, and therefore they cause primarily moderate geospace activity. Sheaths of weak and strong B field ejecta have distinct properties, but differences in their geoeffectiveness are less drastic. Sheaths of fast and strong ejecta push the subsolar magnetopause significantly earthward, often even beyond geostationary orbit. Slow-ejecta sheaths also compress the magnetopause significantly due to their large densities that are likely a result of their relatively long propagation times and source near the streamer belt. We find the regions near the shock and ejecta leading edge to be the most geoeffective parts of the sheath. These regions are also associated with the largest B field magnitudes, out-of-ecliptic fields, and field fluctuations as well as largest speeds and densities. The variations, however, depend on driver properties. Forecasting sheath properties is challenging due to their variable nature, but the dependence on ejecta properties determined in this work could help to estimate sheath geoeffectiveness through remote-sensing coronal mass ejection observations.
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| 10. |
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