| 1. |
|
|
| 2. |
|
|
| 3. |
-
- 2019
-
Tidskriftsartikel (refereegranskat)
|
|
| 4. |
- Wang, Zhaoming, et al.
(författare)
-
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
-
Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
|
|
| 5. |
- You, Xiaohu, et al.
(författare)
-
Towards 6G wireless communication networks: vision, enabling technologies, and new paradigm shifts
- 2021
-
Ingår i: Science China Information Sciences. - : Science Press. - 1674-733X .- 1869-1919. ; 64:1
-
Forskningsöversikt (refereegranskat)abstract
- The fifth generation (5G) wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized, such as mass connectivity, ultra-reliability, and guaranteed low latency. However, 5G will not meet all requirements of the future in 2030 and beyond, and sixth generation (6G) wireless communication networks are expected to provide global coverage, enhanced spectral/energy/cost efficiency, better intelligence level and security, etc. To meet these requirements, 6G networks will rely on new enabling technologies, i.e., air interface and transmission technologies and novel network architecture, such as waveform design, multiple access, channel coding schemes, multi-antenna technologies, network slicing, cell-free architecture, and cloud/fog/edge computing. Our vision on 6G is that it will have four new paradigm shifts. First, to satisfy the requirement of global coverage, 6G will not be limited to terrestrial communication networks, which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle (UAV) communication networks, thus achieving a space-air-ground-sea integrated communication network. Second, all spectra will be fully explored to further increase data rates and connection density, including the sub-6 GHz, millimeter wave (mmWave), terahertz (THz), and optical frequency bands. Third, facing the big datasets generated by the use of extremely heterogeneous networks, diverse communication scenarios, large numbers of antennas, wide bandwidths, and new service requirements, 6G networks will enable a new range of smart applications with the aid of artificial intelligence (AI) and big data technologies. Fourth, network security will have to be strengthened when developing 6G networks. This article provides a comprehensive survey of recent advances and future trends in these four aspects. Clearly, 6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears.
|
|
| 6. |
- Pan, Fei, et al.
(författare)
-
Threshold-Free Physical Layer Authentication Based on Machine Learning for Industrial Wireless CPS
- 2019
-
Ingår i: IEEE Transactions on Industrial Informatics. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1551-3203 .- 1941-0050. ; 15:12, s. 6481-6491
-
Tidskriftsartikel (refereegranskat)abstract
- Wireless industrial cyber-physical systems are increasingly popular in critical manufacturing processes. These kinds of systems, besides high performance, require strong security and are constrained by low computational capabilities. Physical layer authentication (PHY-AUC) is a promising solution to meet these requirements. However, the existing threshold-based PHY-AUC methods only perform ideally in stationary scenarios. To improve the performance of PHY-AUC in mobile scenarios, this article proposes a novel threshold-free PHY-AUC method based on machine learning (ML), which replaces the traditional threshold-based decision-making with more adaptive classification based on ML. This article adopts channel matrices estimated by the wireless nodes as the authentication input and investigates the optimal dimension of the channel matrices to further improve the authentication accuracy without increasing too much computational burden. Extensive simulations are conducted based on a real industrial dataset, with the aim of tuning the authentication performance, then further field validations are performed in an industrial factory. The results from both the simulations and validations show that the proposed method significantly improves the authentication accuracy.
|
|
| 7. |
- Pan, Qinying, et al.
(författare)
-
Ultrafast charge transfer dynamics in 2D covalent organic frameworks/Re-complex hybrid photocatalyst
- 2022
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- Rhenium(I)-carbonyl-diimine complexes have emerged as promising photocatalysts for carbon dioxide reduction with covalent organic frameworks recognized as perfect sensitizers and scaffold support. Such Re complexes/covalent organic frameworks hybrid catalysts have demonstrated high carbon dioxide reduction activities but with strong excitation energy-dependence. In this paper, we rationalize this behavior by the excitation energy-dependent pathways of internal photo-induced charge transfer studied via transient optical spectroscopies and time-dependent density-functional theory calculation. Under band-edge excitation, the excited electrons are quickly injected from covalent organic frameworks moiety into catalytic RheniumI center within picosecond but followed by fast backward geminate recombination. While under excitation with high-energy photon, the injected electrons are located at high-energy levels in RheniumI centers with longer lifetime. Besides those injected electrons to RheniumI center, there still remain some long-lived electrons in covalent organic frameworks moiety which is transferred back from RheniumI. This facilitates the two-electron reaction of carbon dioxide conversion to carbon monoxide.
|
|
| 8. |
|
|
| 9. |
- Tang, Ling Hong, et al.
(författare)
-
Investigation on Thermal-Hydraulic Performance in a Printed Circuit Heat Exchanger with Airfoil and Vortex Generator Fins for Supercritical Liquefied Natural Gas
- 2020
-
Ingår i: Heat Transfer Engineering. - : Informa UK Limited. - 0145-7632 .- 1521-0537. ; , s. 1-21
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, the thermal and hydraulic performances of six different printed circuit heat exchanger (PCHE) configurations with supercritical liquefied natural gas as the working fluid are studied by a numerical method. Firstly, the thermal and hydraulic performances of the PCHE with airfoil fins are investigated at different operating pressures, which indicate that the PCHE with airfoil fins has better thermal performance but worse hydraulic performance when it operates at higher pressure condition. Furthermore, the effects of different PCHE configurations on the thermal and hydraulic performances are analyzed in detail. The results show that delta vortex generators (VGs) arranged upstream the airfoils can provide better thermal performance than VGs arranged downstream the airfoils, and the thermal performance of the common-flow-up configuration is not always better than the common-flow-down configuration. Finally, the overall heat transfer performance of PCHEs is evaluated by the volume goodness criterion under the same mass flow rate. The results show that the straight channel PCHE with front common-flow-up delta VG and airfoil fins has the best volume goodness factor among the six PCHE configurations.
|
|
| 10. |
- Tang, Ling Hong, et al.
(författare)
-
Thermal Performance Analysis in a Zigzag Channel Printed Circuit Heat Exchanger under Different Conditions
- 2022
-
Ingår i: Heat Transfer Engineering. - : Informa UK Limited. - 0145-7632 .- 1521-0537. ; 43:7, s. 567-583
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, the effect of axial heat conduction on thermal performance in a zigzag channel printed circuit heat exchanger (PCHE) with supercritical liquefied natural gas as the working fluid is studied by a numerical method under different conditions. The influence factors include Reynolds number, operating pressure, inlet temperatures of the cold side, and wall thermal conductivity. The results indicate that the axial heat conduction can greatly affect the thermal performance of the PCHE at low Reynolds numbers but decrease it at high Reynolds numbers for different working conditions. At the same average Reynolds number, the thermal performance of the PCHE decreases as the pressure increases, and the inlet temperature of 195 K provides the best thermal performance while the inlet temperature of 220 K is the worst among the three different inlet temperatures of the cold side. Furthermore, the reduction of wall thermal conductivity can improve the thermal performance of the PCHE due to the influence of axial heat conduction in the separation wall.
|
|
