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- Liu, Zhigang, et al.
(författare)
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Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1, s. 855-
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Tidskriftsartikel (refereegranskat)abstract
- Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
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| 2. |
- Wu, Junru, et al.
(författare)
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Unique tridentate coordination tailored solvation sheath towards highly stable lithium metal batteries
- 2023
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Ingår i: Advanced Materials. - : Wiley-VCH Verlagsgesellschaft. - 0935-9648 .- 1521-4095. ; 35:38
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Tidskriftsartikel (refereegranskat)abstract
- Electrolyte optimization by solvent molecule design has been recognized as an effective approach for stabilizing lithium (Li) metal batteries. However, the coordination pattern of Li+ with solvent molecules has been sparsely considered. Here, we report an electrolyte design strategy based on bi/tridentate chelation of Li+ and solvent to tune the solvation structure. As a proof of concept, a novel solvent with multi oxygen coordination sites is demonstrated to facilitate the formation of an anion-aggregated solvation shell, enhancing the interfacial stability and de-solvation kinetics. As a result, the as-developed electrolyte exhibits ultra-stable cycling over 1400 h in symmetric cells with 50 ?m-thin Li foils. When paired with high-loading LiFePO4, full cells maintain 92% capacity over 500 cycles and deliver improved electrochemical performances over a wide temperature range from -10 °C to 60 °C. Furthermore, the concept is validated in a pouch cell (570 mAh), achieving a capacity retention of 99.5% after 100 cycles. This brand-new insight on electrolyte engineering provides guidelines for practical high-performance Li metal batteries. This article is protected by copyright. All rights reserved
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