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- Heier, C. R., et al.
(författare)
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Multi-Omics Identifies Circulating miRNA and Protein Biomarkers for Facioscapulohumeral Dystrophy
- 2020
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Ingår i: Journal of Personalized Medicine. - : MDPI AG. - 2075-4426. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- The development of therapeutics for muscle diseases such as facioscapulohumeral dystrophy (FSHD) is impeded by a lack of objective, minimally invasive biomarkers. Here we identify circulating miRNAs and proteins that are dysregulated in early-onset FSHD patients to develop blood-based molecular biomarkers. Plasma samples from clinically characterized individuals with early-onset FSHD provide a discovery group and are compared to healthy control volunteers. Low-density quantitative polymerase chain reaction (PCR)-based arrays identify 19 candidate miRNAs, while mass spectrometry proteomic analysis identifies 13 candidate proteins. Bioinformatic analysis of chromatin immunoprecipitation (ChIP)-seq data shows that the FSHD-dysregulated DUX4 transcription factor binds to regulatory regions of several candidate miRNAs. This panel of miRNAs also shows ChIP signatures consistent with regulation by additional transcription factors which are up-regulated in FSHD (FOS, EGR1, MYC, and YY1). Validation studies in a separate group of patients with FSHD show consistent up-regulation of miR-100, miR-103, miR-146b, miR-29b, miR-34a, miR-454, miR-505, and miR-576. An increase in the expression of S100A8 protein, an inflammatory regulatory factor and subunit of calprotectin, is validated by Enzyme-Linked Immunosorbent Assay (ELISA). Bioinformatic analyses of proteomics and miRNA data further support a model of calprotectin and toll-like receptor 4 (TLR4) pathway dysregulation in FSHD. Moving forward, this panel of miRNAs, along with S100A8 and calprotectin, merit further investigation as monitoring and pharmacodynamic biomarkers for FSHD.
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| 2. |
- Coll, M., et al.
(författare)
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Towards Oxide Electronics: a Roadmap
- 2019
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Ingår i: Applied Surface Science. - : Elsevier BV. - 0169-4332 .- 1873-5584. ; 482, s. 1-93
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Tidskriftsartikel (refereegranskat)abstract
- At the end of a rush lasting over half a century, in which CMOS technology has been experiencing a constant and breathtaking increase of device speed and density, Moore’s law is approaching the insurmountable barrier given by the ultimate atomic nature of matter. A major challenge for 21st century scientists is finding novel strategies, concepts and materials for replacing silicon-based CMOS semiconductor technologies and guaranteeing a continued and steady technological progress in next decades. Among the materials classes candidate to contribute to this momentous challenge, oxide films and heterostructures are a particularly appealing hunting ground. The vastity, intended in pure chemical terms, of this class of compounds, the complexity of their correlated behaviour, and the wealth of functional properties they display, has already made these systems the subject of choice, worldwide, of a strongly networked, dynamic and interdisciplinary research community. Oxide science and technology has been the target of a wide four-year project, named Towards Oxide-Based Electronics (TO-BE), that has been recently running in Europe and has involved as participants several hundred scientists from 29 EU countries. In this review and perspective paper, published as a final deliverable of the TO-BE Action, the opportunities of oxides as future electronic materials for Information and Communication Technologies ICT and Energy are discussed. The paper is organized as a set of contributions, all selected and ordered as individual building blocks of a wider general scheme. After a brief preface by the editors and an introductory contribution, two sections follow. The first is mainly devoted to providing a perspective on the latest theoretical and experimental methods that are employed to investigate oxides and to produce oxide-based films, heterostructures and devices. In the second, all contributions are dedicated to different specific fields of applications of oxide thin films and heterostructures, in sectors as data storage and computing, optics and plasmonics, magnonics, energy conversion and harvesting, and power electronics.
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| 7. |
- Panigrahi, P., et al.
(författare)
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Efficient Adsorption Characteristics of Pristine and Silver-Doped Graphene Oxide Towards Contaminants : A Potential Membrane Material for Water Purification?
- 2018
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Ingår i: ChemPhysChem. - : Wiley-VCH Verlag. - 1439-4235 .- 1439-7641. ; 19:17, s. 2250-2257
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Tidskriftsartikel (refereegranskat)abstract
- In this work, we have investigated the potential of pristine and silver (Ag)-functionalized graphene oxide monolayers GO (GO−Ag) as efficient membranes for water filtration. Our first principles calculations based on density functional theory (DFT) reveal the hydrophilic nature of GO surfaces. The phonon frequency calculations within density functional perturbation theory (DFPT) confirmed the stability of GO sheets in aqueous media. Van der Waals-corrected binding energies of GO sheet towards heavy metals suggest that even pristine GO sheets are completely impermeable to various heavy metals like arsenic (As) and lead (Pb). However, compared to GO, the GO−Ag sheets have a much higher affinity towards the three amino acids histidine, phenyl-alanine and tyrosine, which are the main component of a bacteria cell wall. The GO−Ag sheet is found to be extremely efficient for bacteria inactivation.
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| 8. |
- Panigrahi, P., et al.
(författare)
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Improved Adsorption and Migration of Divalent Ions Over C4N Nanosheets : Potential Anode for Divalent Batteries
- 2020
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Ingår i: Surfaces and Interfaces. - : Elsevier BV. - 2468-0230. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Divalent ion batteries are potential substitutes to existing rechargeable batteries because of the high-energy density, safety, and low cost. However, the applications of divalent batteries are strongly dependent on the availability of efficient electrode materials. We herein report the adsorption and migration mechanism of divalent ions like Mg+2 and Ca+2, on two-dimensional carbon nitride monolayer (C4N). The adsorption of both Mg and Ca ions are much stronegr on C4N saturated with functional groups like hydrogen (-H), hydroxyl (-OH), and carboxylic (-COOH) as compared to the pristine monolayers, which implies the improvement in metal storage caused by the functional groups. On functionalized C4N, the first Mg binds within the binding energy range of 1.5-2.2 eV having migration barrier, at the saturated sites, of around 0.5 eV, which indicates desirable binding and robust diffuse. However, the functional groups tend to act as the trapping sites for Ca ions and the diffusion might get hindered as compared to Mg ions. In addition to binding and diffusion mechanism, charge transfer, electronic structures and open circuit volatges have also been calculated for both Mg and Ca on pristine and functionalized C4N monolayers. We find that -H, -OH, and -COOH play important role for the cyclic performance of C4N as the prospective anode material for divalent ion batteries.
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| 9. |
- Panigrahi, P., et al.
(författare)
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Light metal decorated graphdiyne nanosheets for reversible hydrogen storage
- 2018
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Ingår i: Nanotechnology. - : Institute of Physics (IOP). - 0957-4484 .- 1361-6528. ; 29:35
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Tidskriftsartikel (refereegranskat)abstract
- The sensitive nature of molecular hydrogen (H-2) interaction with the surfaces of pristine and functionalized nanostructures, especially two-dimensional materials, has been a subject of debate for a while now. An accurate approximation of the H-2 adsorption mechanism has vital significance for fields such as H2 storage applications. Owing to the importance of this issue, we have performed a comprehensive density functional theory (DFT) study by means of several different approximations to investigate the structural, electronic, charge transfer and energy storage properties of pristine and functionalized graphdiyne (GDY) nanosheets. The dopants considered here include the light metals Li, Na, K, Ca, Sc and Ti, which have a uniform distribution over GDY even at high doping concentration due to their strong binding and charge transfer mechanism. Upon 11% of metal functionalization, GDY changes into a metallic state from being a small band-gap semiconductor. Such situations turn the dopants to a partial positive state, which is favorable for adsorption of H-2 molecules. The adsorption mechanism of H-2 on GDY has been studied and compared by different methods like generalized gradient approximation, van der Waals density functional and DFT-D3 functionals. It has been established that each functionalized system anchors multiple H-2 molecules with adsorption energies that fall into a suitable range regardless of the functional used for approximations. A significantly high H-2 storage capacity would guarantee that light metal-doped GDY nanosheets could serve as efficient and reversible H-2 storage materials.
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| 10. |
- Sing, Ranumayee, et al.
(författare)
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A whale optimization algorithm based resource allocation scheme for cloud-fog based iot applications
- 2022
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Ingår i: Electronics. - : MDPI. - 2079-9292. ; 11:19
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Tidskriftsartikel (refereegranskat)abstract
- Fog computing has been prioritized over cloud computing in terms of latency-sensitive Internet of Things (IoT) based services. We consider a limited resource-based fog system where real-time tasks with heterogeneous resource configurations are required to allocate within the execution deadline. Two modules are designed to handle the real-time continuous streaming tasks. The first module is task classification and buffering (TCB), which classifies the task heterogeneity using dynamic fuzzy c-means clustering and buffers into parallel virtual queues according to enhanced least laxity time. The second module is task offloading and optimal resource allocation (TOORA), which decides to offload the task either to cloud or fog and also optimally assigns the resources of fog nodes using the whale optimization algorithm, which provides high throughput. The simulation results of our proposed algorithm, called whale optimized resource allocation (WORA), is compared with results of other models, such as shortest job first (SJF), multi-objective monotone increasing sorting-based (MOMIS) algorithm, and Fuzzy Logic based Real-time Task Scheduling (FLRTS) algorithm. When 100 to 700 tasks are executed in 15 fog nodes, the results show that the WORA algorithm saves 10.3% of the average cost of MOMIS and 21.9% of the average cost of FLRTS. When comparing the energy consumption, WORA consumes 18.5% less than MOMIS and 30.8% less than FLRTS. The WORA also performed 6.4% better than MOMIS and 12.9% better than FLRTS in terms of makespan and 2.6% better than MOMIS and 4.3% better than FLRTS in terms of successful completion of tasks.
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