| 1. |
- Haiduk, Yulyan, et al.
(författare)
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WO3–graphene–Cu nanocomposites for CO, NO2 and acetone gas sensors
- 2022
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Ingår i: Nano-Structures & Nano-Objects. - : Elsevier BV. - 2352-507X. ; 29, s. 100824-
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Tidskriftsartikel (refereegranskat)abstract
- The control of indoor air quality and the detection of toxic gases and volatile organic compounds are important tasks for improving life and work conditions, and are highly demanded in a variety of industrial, agricultural and environmental applications. This requires the development of special gas sensing materials with a high sensing response to a variety of gases of a different chemical nature. Herein we report a study on the synthesis, characterization and investigation of the gas sensing properties of WO3 -graphene–Cu composite nanomaterials. The nanomaterials have a closely interconnected defective structure with developed surfaces and are characterized by an enhanced sensing response to CO, NO2 and acetone. The composite nanomaterials with WO3 crystallite sizes of 13–17 nm were synthesized by a modified sol–gel method, where pre-synthesized graphene@Cu nanopowder, obtained by the solution combustion method, was added into an H2WO4 gel before the xerogel formation stage. The graphene@Cu flakes played the role of the centers of WO3 crystallite nucleation, leading to the formation of mutually interconnected crystalline structures. The graphene@Cu composite tends to accumulate on the tungsten oxide surfaces, causing the formation of structural defects, influencing the surface energy state and concentration of free electrons. The concentration of defects decreases with the increase of graphene@Cu from 1 to 4 wt%, which also affects the gas sensing properties of the WO3-graphene@Cu composites. The highest sensing response to CO and acetone of 19.7 and 21.4, respectively, were detected for the composite with 1 wt% of graphene@Cu. The composite with 2 wt.% of graphene@Cu additive showed the highest sensing response to NO2.
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| 2. |
- Khort, Alexander, Dr, 1987-, et al.
(författare)
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High-performance selective NO2 gas sensor based on In2O3–graphene–Cu nanocomposites
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The control of atmosphere content and concentration of specific gases are important tasks in many industrial processes, agriculture, environmental and medical applications. Thus there is a high demand to develop new advanced materials with enhanced gas sensing characteristics including high gas selectivity. Herein we report the result of a study on the synthesis, characterization, and investigation of gas sensing properties of In2O3–graphene–Cu composite nanomaterials for sensing elements of single-electrode semiconductor gas sensors. The nanocomposite has a closely interconnected and highly defective structure, which is characterized by high sensitivity to various oxidizing and reducing gases and selectivity to NO2. The In2O3-based materials were obtained by sol–gel method, by adding 0–6 wt% of pre-synthesized graphene–Cu powder into In-containing gel before xerogel formation. The graphene–Cu flakes played the role of centers for In2O3 nucleation and then crystal growth terminators. This led to the formation of structural defects, influencing the surface energy state and concentration of free electrons. The concentration of defects increases with the increase of graphene–Cu content from 1 to 4 wt%, which also affects the gas-sensing properties of the nanocomposites. The sensors show a high sensing response to both oxidizing (NO2) and reducing (acetone, ethanol, methane) gases at an optimal working heating current of 91–161 mA (280–510 °C). The sensor with nanocomposite with 4 wt% of graphene–Cu additive showed the highest sensitivity to NO2 (46 ppm) in comparison with other tested gases with an absolute value of sensing response of (− ) 225 mV at a heating current of 131 mA (430 °C) and linear dependence of sensing response to NO2 concentration.
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| 3. |
- Kravchenko, Ekaterina, et al.
(författare)
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High-temperature characterization of oxygen-eficient K2NiF4-type Nd2-xSrxNiO4-delta O4-delta (x=1.0-1.6) for potential SOFC/SOEC applications
- 2015
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7488 .- 2050-7496. ; 3:47, s. 23852-23863
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Tidskriftsartikel (refereegranskat)abstract
- Previously unexplored oxygen-deficient RuddLesden-Popper Nd2-xSrxNiO4-delta (x = 1.0-1.6) nickelates were evaluated for potential use as oxygen electrode materials for solid oxide fuel and electrolysis ceRs, with emphasis on structural stability, oxygen nonstoichiometry, dimensional changes, and electrical properties. Nd2-xSrxNiO4-delta ceramics possess the K2NiF4-type tetragonal structure under oxidizing conditions at 25-1000 degrees C. Acceptor-type substitution by strontium is compensated by the generation of eLectron-hoLes and oxygen vacancies. Oxygen deficiency increases with temperature and strontium doping reaching -1/8 of oxygen sites for x = 1.6 at 1000 degrees C in air. Strongly anisotropic expansion of the tetragonal Lattice on heating correlated with oxygen nonstoichiometry changes results in an anomalous dilatometric behavior of Nd2-xSrxNiO4-delta ceramics under oxidizing conditions. Moderate thermal expansion coefficients, (11-14) x 10(-6) K-1, ensure however thermomechanical compatibility with common solid electrolytes. Reduction in inert atmosphere induces oxygen vacancy ordering accompanied by a contraction of the Lattice and a decrease of its symmetry to orthorhombic. Nd2-xSrxNiO4-delta ceramics exhibit a p-type metallic-Like electrical conductivity at 500-1000 degrees C under oxidizing conditions, with the highest conductivity (290 S cm(-1) at 900 degrees C in air) observed for x = 1.2. The high Lev& of oxygen deficiency in Sr-rich Nd2-xSrxNiO4 impLies enhanced mixed ionic-electronic transport favorable for electrode applications.
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| 4. |
- Pankov, Dmitry, et al.
(författare)
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In vivo immuno-targeting of an extracellular epitope of membrane bound preferentially expressed antigen in melanoma (PRAME)
- 2017
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:39, s. 65917-65931
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Tidskriftsartikel (refereegranskat)abstract
- Preferentially Expressed Antigen in Melanoma (PRAME) is a cancer/testis antigen that is overexpressed in a broad range of malignancies, while absent in most healthy human tissues, making it an attractive diagnostic cancer biomarker and therapeutic target. Although commonly viewed as an intracellular protein, we have demonstrated that PRAME has a membrane bound form with an external epitope targetable with conventional antibodies. We generated a polyclonal antibody (Membrane associated PRAME Antibody 1, MPA1) against an extracellular peptide sequence of PRAME. Binding of MPA1 to recombinant PRAME was evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Flow cytometry and confocal immunofluorescence microscopy of MPA1 was performed on multiple tumor cell lines. Reverse Transcription Polymerase Chain Reaction (RTPCR) for PRAME was conducted to compare protein and transcriptional expression levels. We demonstrated a robust proof-of-concept for PRAME targeting in vivo by radiolabeling MPA1 with zirconium-89 (89Zr-DFO-MPA1) and demonstrating high specific uptake in PRAME expressing tumors. To our knowledge, this is the first time a cancer testis antigen has been targeted using conventional antibody technologies. Thus, PRAME can be exploited for multiple clinical applications, including targeted therapy, diagnostic imaging and treatment guidance in a widerange of malignancies, with minimal off-target toxicity.
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| 5. |
- Veach, Darren R., et al.
(författare)
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PSA-Targeted Alpha-, Beta-, and Positron-emitting immunotheranostics in murine prostate cancer models and nonhuman primates
- 2021
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 27:7, s. 2050-2060
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Most patients with prostate cancer treated with androgen receptor (AR) signaling inhibitors develop therapeutic resistance due to restoration of AR functionality. Thus, there is a critical need for novel treatment approaches. Here we investigate the theranostic potential of hu5A10, a humanized mAb specifically targeting free PSA (KLK3). Experimental Design: LNCaP-AR (LNCaP with overexpression of wildtype AR) xenografts (NSG mice) and KLK3-Hi- Myc transgenic mice were imaged with 89Zr- or treated with 90Y- or 225Ac-labeled hu5A10; biodistribution and subcellular localization were analyzed by gamma counting, PET, autoradiography, and microscopy. Therapeutic efficacy of [225Ac]hu5A10 and [90Y]hu5A10 in LNCaP-AR tumors was assessed by tumor volume measurements, time to nadir (TTN), time to progression (TTP), and survival. Pharmacokinetics of [89Zr]hu5A10 in nonhuman primates (NHP) were determined using PET. Results: Biodistribution of radiolabeled hu5A10 constructs was comparable in different mouse models. Specific tumor uptake increased over time and correlated with PSA expression. Treatment with [90Y]/[225Ac]hu5A10 effectively reduced tumor burden and prolonged survival (P ≤ 0.0054). Effects of [90Y]hu5A10 were more immediate than [225Ac]hu5A10 (TTN, P < 0.0001) but less sustained (TTP, P < 0.0001). Complete responses were observed in 7 of 18 [225Ac]hu5A10 and 1 of 9 mice [90Y]hu5A10. Pharmacokinetics of [89Zr]hu5A10 were consistent between NHPs and comparable with those in mice. [89Zr]hu5A10-PET visualized the NHP-prostate over the 2-week observation period. Conclusions: We present a complete preclinical evaluation of radiolabeled hu5A10 in mouse prostate cancer models and NHPs, and establish hu5A10 as a new theranostic agent that allows highly specific and effective downstream targeting of AR in PSAexpressing tissue. Our data support the clinical translation of radiolabeled hu5A10 for treating prostate cancer.
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