| 1. |
- Castelnuovo, Gianluca, et al.
(författare)
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What Is the Role of the Placebo Effect for Pain Relief in Neurorehabilitation? : Clinical Implications From the Italian Consensus Conference on Pain in Neurorehabilitation
- 2018
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Ingår i: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 9
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Forskningsöversikt (refereegranskat)abstract
- Background: It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the efficacy of neurorehabilitation treatments. Since its intensity varies across neurological disorders, the Italian Consensus Conference on Pain in Neurorehabilitation (ICCP) summarized the studies on this field to provide guidance on its use.Methods: A review of the existing reviews and meta-analyses was performed to assess the magnitude of the placebo effect in disorders that may undergo neurorehabilitation treatment. The search was performed on Pubmed using placebo, pain, and the names of neurological disorders as keywords. Methodological quality was assessed using a pre-existing checklist. Data about the magnitude of the placebo effect were extracted from the included reviews and were commented in a narrative form.Results: 11 articles were included in this review. Placebo treatments showed weak effects in central neuropathic pain (pain reduction from 0.44 to 0.66 on a 0-10 scale) and moderate effects in postherpetic neuralgia (1.16), in diabetic peripheral neuropathy (1.45), and in pain associated to HIV (1.82). Moderate effects were also found on pain due to fibromyalgia and migraine; only weak short-term effects were found in complex regional pain syndrome. Confounding variables might have influenced these results.Clinical implications: These estimates should be interpreted with caution, but underscore that the placebo effect can be exploited in neurorehabilitation programs. It is not necessary to conceal its use from the patient. Knowledge of placebo mechanisms can be used to shape the doctor-patient relationship, to reduce the use of analgesic drugs and to train the patient to become an active agent of the therapy.
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| 2. |
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| 3. |
- Grisendi, Giulia, et al.
(författare)
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GMP-manufactured density gradient media for optimized mesenchymal stromal/stem cell isolation and expansion
- 2010
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Ingår i: Cytotherapy. - : Elsevier BV. - 1465-3249 .- 1477-2566. ; 12:4, s. 466-477
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AIMS: Bone marrow (BM) mesenchymal stromal/stem cells (MSC) are therapeutic tools in regenerative medicine and oncology. MSC isolation is often performed starting from a separation step based on research-grade 1.077 g/mL density gradient media (DGM). However, MSC clinical application should require the introduction of good manufacturing practice (GMP) reagents. We took advantage of two novel GMP DGM with densities of 1.077 and 1.073 g/mL (Ficoll-Paque PREMIUM and Ficoll-Paque PREMIUM 1.073, respectively) to test whether these reagents could isolate MSC efficiently while simultaneously comparing their performance. METHODS: BM samples were processed using either 1.077 or 1.073 g/mL GMP DGM. BM mononucleated cell (MNC) fractions were analyzed for viability, immunophenotype, clonogenic potential, ex vivo expansion and differentiation potential. RESULTS: No differences were noticed in cell recovery and viability between the groups. Fluorescence-activated cell-sorting (FACS) analyzes on freshly isolated cells indicated that the 1.073 g/mL GMP DGM more efficiently depleted the CD45(+) fraction in comparison with 1.077 GMP DGM. Moreover, in the 1.073 group, fibroblastic colony-forming units (CFU-F) were 1.5 times higher and the final MSC yield 1.8 times increased after four passages. Both reagents isolated MSC with the expected phenotype; however, 1.073-isolated MSC showed a higher expression of CD90, CD146 and GD2. Additionally, MSC from both groups were capable of fully differentiating into bone, adipose cells and cartilage. CONCLUSIONS: Both GMP DGM enriched MSC from BM samples, suggesting that these reagents would be suitable for clinical-grade expansions. In addition, the density of 1.073 g/mL provides a significant advantage over 1.077 g/mL GMP DGM, impacting the quantity of MSC obtained and reducing the ex vivo expansion time for optimized cell-based clinical applications.
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| 4. |
- Muhammad, Ajmal, et al.
(författare)
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On the Scalability of Connectivity Services in a Multi-Operator Orchestrator Sandbox
- 2018
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Ingår i: 2018 Optical Fiber Communications Conference and Exposition, OFC 2018 - Proceedings. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781943580385
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Konferensbidrag (refereegranskat)abstract
- The paper investigates the performance of a multi-domain orchestrator (MdO) deployed in a real multi-domain European testbed. Results show how the MdO prototype scales well with the number of domains advertised and connectivity services provisioned.
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| 5. |
- Paolucci, F., et al.
(författare)
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Interoperable multi-domain delay-aware provisioning using Segment Routing monitoring and BGP-LS advertisement
- 2016
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Ingår i: ECOC 2016 42th European Conference on Optical Communication Proceedings, September 18 - 22, 2016, Düsseldorf, Germany. - : Institute of Electrical and Electronics Engineers (IEEE). - 9783800742745 ; , s. 190-192
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Konferensbidrag (refereegranskat)abstract
- This paper demonstrates a multi-domain SDN orchestrator using delay information to provision network services using BGP-LS and a novel monitoring system enabled by Segment Routing. Moreover, it is the first implementation and interoperability of the BGP-LS extensions for TE metrics.
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| 6. |
- Sgambelluri, Andrea, et al.
(författare)
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A multi-operator network service orchestration prototype : The 5G exchange
- 2017
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Ingår i: 2017 Optical Fiber Communications Conference and Exhibition, OFC 2017 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781943580231
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Konferensbidrag (refereegranskat)abstract
- In the context of the 5GEx Project, a Multi-domain Orchestrator is in charge of creating, deploying, and terminating Network Services spanning across multiple-operators. This live demo showcases the main functionalities of the 5GEx system.
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| 7. |
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| 8. |
- Sgambelluri, A., et al.
(författare)
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Orchestrating QoS-based Connectivity Services in a Multi-Operator Sandbox
- 2019
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Ingår i: Journal of Optical Communications and Networking. - : OPTICAL SOC AMER. - 1943-0620 .- 1943-0639. ; 11:2, s. A196-A208
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Tidskriftsartikel (refereegranskat)abstract
- One of the main features of 5G networks is the coordinated orchestration of both information technology (IT) and connectivity resources. This enables the deployment of a flexible and programmable architecture able to provision end-to-end services with different (and sometimes quite) stringent quality of service (QoS) constraints. In this paradigm, service orchestration may take place over single or multiple administrative domains. The 5G Exchange (5GEx) project, building on the software-defined network and the network function virtualization (NFV) concepts, targets the design and the implementation of a multi-domain orchestrator (MdO) prototype for the automatic provisioning of network service across multiple administrative domains. This paper presents an architectural solution, designed and implemented in the context of the 5GEx MdO prototype, that can be used to establish end-to-end connectivity tunnels with QoS constraints (i.e., bandwidth and/or end-to-end delay) connecting virtualized network functions deployed in remote data centers controlled by different providers by means of an innovative stateful backward recursive path-computation-element based computation procedure. The proposed solution has been experimentally validated in terms of scalability, reliability, and end-to-end workflow proof-of-concept. Results show how the designed solution permits the automatic establishment of QoS-based end-to-end tunnels spanning across multi-technology and multi-operator network domains. The orchestration scheme does not present scalability issues for either the advertisement of resources or for the provisioning of connectivity services. Moreover, no issues have been identified from the reliability point of view.
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| 9. |
- Sgambelluri, A., et al.
(författare)
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Orchestration of Network Services across multiple operators : The 5G Exchange prototype
- 2017
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Ingår i: EuCNC 2017 - European Conference on Networks and Communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781538638736
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Konferensbidrag (refereegranskat)abstract
- Future 5G networks will rely on the coordinated allocation of compute, storage, and networking resources in order to meet the functional requirements of 5G services as well as guaranteeing efficient usage of the network infrastructure. However, the 5G service provisioning paradigm will also require a unified infrastructure service market that integrates multiple operators and technologies. The 5G Exchange (5GEx) project, building heavily on the Software-Defined Network (SDN) and the Network Function Virtualization (NFV) functionalities, tries to overcome this market and technology fragmentation by designing, implementing, and testing a multi-domain orchestrator (MdO) prototype for fast and automated Network Service (NS) provisioning over multiple-technologies and spanning across multiple operators. This paper presents a first implementation of the 5GEx MdO prototype obtained by extending existing open source software tools at the disposal of the 5GEx partners. The main functions of the 5GEx MdO prototype are showcased by demonstrating how it is possible to create and deploy NSs in the context of a Slice as a Service (SlaaS) use-case, based on a multi-operator scenario. The 5GEx MdO prototype performance is experimentally evaluated running validation tests within the 5GEx sandbox. The overall time required for the NS deployment has been evaluated considering NSs deployed across two operators.
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