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- Georgiou, Nikos, et al.
(författare)
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Spatio-Seasonal Hypoxia/Anoxia Dynamics and Sill Circulation Patterns Linked to Natural Ventilation Drivers, in a Mediterranean Landlocked Embayment : Amvrakikos Gulf, Greece
- 2021
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Ingår i: Geosciences. - : MDPI. - 2076-3263. ; 11:6
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Tidskriftsartikel (refereegranskat)abstract
- Amvrakikos Gulf is a Mediterranean landlocked, fjord-like embayment and marine protected area suffering from natural, human-induced hypoxia/anoxia and massive fish mortality events. Seasonal marine geophysical and oceanographic surveys were conducted focusing on the water-circulation patterns at the sill and the spatial-seasonal distribution of dissolved oxygen (DO) in the gulf. Detailed surveys at the sill, the only communication route between the gulf and the open sea, revealed a two-layer water circulation pattern (top brackish outflow-bottom seawater inflow) and the role of the tide in the daily water exchange. Statistical analysis of the known natural drivers of DO distribution (density difference between the Ionian Sea and Amvrakikos, river inflow, wind) revealed that horizontal density gradients strongly affect anoxia reduction and seafloor oxygenation, while river inflow and wind mainly oxygenate volume/areas located above or within the pycnocline range, with DO concentrations > 2 mg/L. Complex geomorphology with well-formed internal basins contributes to the development and preservation of low DO conditions below the pycnocline. Finally, 43% of the seafloor and 36% of the gulf's total water volume are permanently hypoxic, and reach a maximum of 70% and 62%, respectively, in September and July. This work is tailored to future ecosystem management plans, decisions, and future research on coastal ecosystems.
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| 2. |
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| 3. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 4. |
- Kepp, Kasper P., et al.
(författare)
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Panel stacking is a threat to consensus statement validity
- 2024
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Ingår i: Journal of Clinical Epidemiology. - : Elsevier. - 0895-4356 .- 1878-5921. ; 173
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Tidskriftsartikel (refereegranskat)abstract
- Consensus statements can be very influential in medicine and public health. Some of these statements use systematic evidence synthesis but others fail on this front. Many consensus statements use panels of experts to deduce perceived consensus through Delphi processes. We argue that stacking of panel members toward one particular position or narrative is a major threat, especially in absence of systematic evidence review. Stacking may involve financial conflicts of interest, but nonfinancial conflicts of strong advocacy can also cause major bias. Given their emerging importance, we describe here how such consensus statements may be misleading, by analyzing in depth a recent high-impact Delphi consensus statement on COVID-19 recommendations as a case example. We demonstrate that many of the selected panel members and at least 35% of the core panel members had advocated toward COVID-19 elimination (Zero-COVID) during the pandemic and were leading members of aggressive advocacy groups. These advocacy conflicts were not declared in the Delphi consensus publication, with rare exceptions. Therefore, we propose that consensus statements should always require rigorous evidence synthesis and maximal transparency on potential biases toward advocacy or lobbyist groups to be valid. While advocacy can have many important functions, its biased impact on consensus panels should be carefully avoided.
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