| 1. |
- Kumar Sharma, Manish, et al.
(författare)
-
Anticorrosive evaluation of an environmentally benign chromone-thiazole hybrid with excellent anticancer activity
- 2024
-
Ingår i: Journal of Molecular Liquids. - : Elsevier B.V.. - 0167-7322 .- 1873-3166. ; 405
-
Tidskriftsartikel (refereegranskat)abstract
- The research article comprehensively presents salient applications of an environment friendly chromone-thiazole hybrid (CTH) as a potential anticancer molecule and as an organic inhibitor against mild steel (MS) corrosion. The SRB assay used for antiproliferative screening gives excellent IC50 (10.8 μM) against MDA-MB-231 (breast cancer) cell line. Further, CTH has excellent inhibition efficacy (∼97 % at 400 ppm) against MS corrosion in 1 M HCl. The in vitro results of anticancer and anticorrosive evaluation are in good agreement with the computational studies, which include docking, ADME, DFT, MD simulation, and toxicity prediction.
|
|
| 2. |
- Sharma, Manish Kumar, et al.
(författare)
-
Comprehensive investigations of the synergistic effect of chalcone on the anti-corrosion activity of environmentally benign triazole hybrid
- 2023
-
Ingår i: Inorganic Chemistry Communications. - : Elsevier B.V.. - 1387-7003 .- 1879-0259. ; 158
-
Tidskriftsartikel (refereegranskat)abstract
- This research article presents a comprehensive investigation into the corrosion inhibition performance of a 1,2,3-triazole-based hybrid (TCA) with incorporated triazole, chalcone, and amide moieties. The amalgamation of these pharmacologically active moieties synergistically enhances the ability of the TCA hybrid to form protective films on metal surfaces. The study employs a combination of experimental and theoretical methods to assess the corrosion inhibition properties. Multiple sophisticated techniques like weight loss, EIS, PDP, SEM, EDX, and UV–Vis spectroscopy reveals TCA's exceptional inhibitory efficiency (∼99 % at 200 ppm) for mild steel (MS). PDP analysis suggests a mixed-type inhibition mechanism. The experimental findings are further supported by the DFT calculations by exploring the interactions between the inhibitor and mild steel (MS). The remarkable corrosion inhibition efficacy of TCA along with its eco-friendly behavior aligns the present work with the growing global emphasis on sustainability.
|
|
