| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
- Wang, Anqi, et al.
(författare)
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
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Tidskriftsartikel (refereegranskat)abstract
- The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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| 3. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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| 4. |
- Feng, Shaohong, et al.
(författare)
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Dense sampling of bird diversity increases power of comparative genomics
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 587:7833
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Tidskriftsartikel (refereegranskat)abstract
- Whole-genome sequencing projects are increasingly populating the tree of life and characterizing biodiversity(1-4). Sparse taxon sampling has previously been proposed to confound phylogenetic inference(5), and captures only a fraction of the genomic diversity. Here we report a substantial step towards the dense representation of avian phylogenetic and molecular diversity, by analysing 363 genomes from 92.4% of bird families-including 267 newly sequenced genomes produced for phase II of the Bird 10,000 Genomes (B10K) Project. We use this comparative genome dataset in combination with a pipeline that leverages a reference-free whole-genome alignment to identify orthologous regions in greater numbers than has previously been possible and to recognize genomic novelties in particular bird lineages. The densely sampled alignment provides a single-base-pair map of selection, has more than doubled the fraction of bases that are confidently predicted to be under conservation and reveals extensive patterns of weak selection in predominantly non-coding DNA. Our results demonstrate that increasing the diversity of genomes used in comparative studies can reveal more shared and lineage-specific variation, and improve the investigation of genomic characteristics. We anticipate that this genomic resource will offer new perspectives on evolutionary processes in cross-species comparative analyses and assist in efforts to conserve species. A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.
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| 5. |
- Abramowski, A., et al.
(författare)
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Simultaneous multi-wavelength campaign on PKS 2005-489 in a high state
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 533, s. A110-
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Tidskriftsartikel (refereegranskat)abstract
- The high-frequency peaked BL Lac object PKS 2005-489 was the target of a multi-wavelength campaign with simultaneous observations in the TeV gamma-ray (H.E.S.S.), GeV gamma-ray (Fermi/LAT), X-ray (RXTE, Swift), UV (Swift) and optical (ATOM, Swift) bands. This campaign was carried out during a high flux state in the synchrotron regime. The flux in the optical and X-ray bands reached the level of the historical maxima. The hard GeV spectrum observed with Fermi/LAT connects well to the very high energy (VHE, E > 100 GeV) spectrum measured with H.E.S.S. with a peak energy between similar to 5 and 500 GeV. Compared to observations with contemporaneous coverage in the VHE and X-ray bands in 2004, the X-ray flux was similar to 50 times higher during the 2009 campaign while the TeV gamma-ray flux shows marginal variation over the years. The spectral energy distribution during this multi-wavelength campaign was fit by a one zone synchrotron self-Compton model with a well determined cutoff in X-rays. The parameters of a one zone SSC model are inconsistent with variability time scales. The variability behaviour over years with the large changes in synchrotron emission and small changes in the inverse Compton emission does not warrant an interpretation within a one-zone SSC model despite an apparently satisfying fit to the broadband data in 2009.
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| 6. |
- Bal, Nicolas, et al.
(författare)
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Experimental study of radiative heat transfer in a translucent fuel sample exposed to different spectral sources
- 2013
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Ingår i: International Journal of Heat and Mass Transfer. - : Elsevier BV. - 0017-9310 .- 1879-2189. ; 61:1, s. 742-748
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Tidskriftsartikel (refereegranskat)abstract
- Radiative heat transfer to a solid is a key mechanism in fire dynamics, and in-depth absorption is especially of importance for translucent fuels. The sample-heater interaction for radiative heat transfer is experimentally investigated in this study with two different heaters (electric resistance and tungsten lamp) using clear PolyMethylMethAcrylate (PMMA) samples from two different formulations (Plexiglass and Lucite). First, the significant effects of the heater type and operating temperature on the radiative heat transfer are revealed with broadband measurements of transmittance on samples of different thicknesses. Then, the attenuation coefficient in Beer-Lambert's law has been calculated from detailed spectral measurements over the full wavelength range encountered in real fires. The measurements present large spectral heterogeneity. These experimental results and calculation of in-depth absorption are used to explain the reason behind the apparent variation of the fuel absorbance with the sample thickness observed in past studies. The measurement of the spectral intensity emitted by the heaters verifies that the common assumption of blackbody behavior is correct for the electric resistance, whereas the tungsten lamp does not even behave as a greybody. This investigation proofs the necessity of a multi-band radiation model to calculate accurately the fire radiative heat transfer which affects directly the in-depth temperature profiles and hence the pyrolysis process for translucent fuel.
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| 7. |
- Berthon, Pierre, et al.
(författare)
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Aesthetics and ephemerality : observing and preserving the luxury brand
- 2009
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Ingår i: California Management Review. - : SAGE Publications. - 0008-1256 .- 2162-8564. ; 52:1, s. 45-66
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Tidskriftsartikel (refereegranskat)abstract
- While luxury brands are one of the most profitable and fastest growing segments of the brand pantheon, they are the least understood. There is no established definition as to what a luxury brand is; no clear understanding of the value dimensionality of luxury brands; and no rigorous conceptualization of the different types of luxury brands. They are generally treated as homogenous. Little wonder the management of these brands is shrouded in mystery. This article explores the value dimensionality of luxury brands, differentiates among luxury brands, and proposes a typology to help firms understand the managerial implications and challenges of each type. All luxury brands are not the same-they can mean different things to different people or even different things to the same people, which makes target marketing of luxury brands both difficult and important. This also means that they react differently to each other both in times of economic prosperity and in downturns. This article also explores strategies for migrating mass-market brands into luxury brand markets.
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| 8. |
- Boulet, Pascual, et al.
(författare)
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Radiation emission from a heating coil or a halogen lamp on a semitransparent sample
- 2014
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Ingår i: International Journal of Thermal Sciences. - : Elsevier BV. - 1290-0729. ; 77:March, s. 223-232
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Tidskriftsartikel (refereegranskat)abstract
- The radiation emission of the heating coil of a Cone Calorimeter and the one of the halogen lamp of a Fire Propagation Apparatus have been studied experimentally for varying power settings. These are two standard apparatuses used for fire calorimetry. The objective is to characterize and compare the radiative flux spectrum received by a fuel sample during pyrolysis experiments. The deviation from the standard assumption of black or gray emission is discussed. It is observed that the emission of the heating coil can be approximated well to an ideal blackbody, especially in the infrared range. On the contrary, the halogen lamp emission is more complex, non gray, with an important contribution in the visible and in the near infrared ranges. The flux received by a sample exposed to these emitters is predicted using ray tracing simulations. This shows that the irradiation flux and spectrum from the cone can be accurately calculated if the coil temperature is known. The non Lambertian irradiation flux from the lamp is modeled with a combination of diffuse and collimated intensities, representing the direct emission from the lamp itself and the reflection by the mirror at the rear side. For both emitters, the irradiation is confirmed to be approximately uniform over the surface of a sample 5 cm large (maximum deviation of ±2% on the incident flux). The uniformity decreases for larger samples, but the ratio of the flux at the center to average flux is still 1.04 for standard 10 cm × 10 cm samples under the cone. For illustration purposes, the influence of the spectral characteristics of the emitter is studied in the case of a sample of PMMA, a non gray translucent medium. Using recently published measurements of PMMA absorptivity, the absorbed flux by a 3 cm thick sample is predicted. In the case of an incident flux of 20 kW/m2, the calculated average absorptivity of the sample is 0.91 under the cone, while it is 0.32 under the FPA lamp. These calculations involve absorption data of a virgin sample at room temperature and consequently the numerical results only hold for the initial instants of irradiation. However, the very large differences in radiative behavior show that important discrepancies in the pyrolysis behavior are expected between the two emitters. This might have consequences for fire testing and inter comparisons of flammability results worth further investigation.
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| 9. |
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| 10. |
- Grant, Philip, et al.
(författare)
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Operatic flash mob : Consumer arousal, connectedness and emotion
- 2012
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Ingår i: Journal of Consumer Behaviour. - : Wiley. - 1472-0817 .- 1479-1838. ; 11:3, s. 244-251
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the influence of an operatic flash mob on consumer behaviour and consumer experience in a public market. A field experiment was conducted to assess the impact of operatic music on consumers' emotions and connectedness in three conditions: spontaneous live music (flash mob), recorded music, and no music. We analyse audience responses to the shopping experience in all three conditions, with particular focus on temporary group formation and felt emotion. Results show that the flash mob enhanced consumer arousal, connectedness and positive emotions, as well as consumer-to-consumer interaction.
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