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Sökning: WFRF:(Parish CL)

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  • Parish, CL, et al. (författare)
  • Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model
  • 2007
  • Ingår i: Development (Cambridge, England). - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 134:15, s. 2881-2887
  • Tidskriftsartikel (refereegranskat)abstract
    • Death and lack of functional regeneration of midbrain dopaminergic (DA)neurons, decreased DA input in the target striatum and movement anomalies characterise Parkinson's disease (PD). There is currently no cure for PD. One way to promote recovery would be to induce or enhance DA neurogenesis. Whether DA neurogenesis occurs in the adult midbrain is a matter of debate. Here, we describe the creation of a salamander 6-hydroxydopamine model of PD to examine midbrain DA regeneration. We demonstrate a robust and complete regeneration of the mesencephalic and diencephalic DA system after elimination of DA neurons. Regeneration is contributed by DA neurogenesis, leads to histological restoration, and to full recovery of motor behaviour. Molecular analyses of the temporal expression pattern of DA determinants indicate that the regenerating DA neurons mature along a similar developmental program as their mammalian counterparts during embryogenesis. We also find that the adult salamander midbrain can reactivate radial glia-like ependymoglia cells that proliferate. The salamander model provides insights into the mechanisms of DA regeneration/neurogenesis and may contribute to the development of novel regenerative strategies for the mammalian brain.
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  • Parish, CL, et al. (författare)
  • Stem-cell-based strategies for the treatment of Parkinson's disease
  • 2007
  • Ingår i: Neuro-degenerative diseases. - : S. Karger AG. - 1660-2854 .- 1660-2862. ; 4:4, s. 339-347
  • Tidskriftsartikel (refereegranskat)abstract
    • <i>Background: </i>Cell transplantation to replace lost neurons in neurodegenerative diseases such as Parkinson’s disease (PD) offers a hopeful prospect for many patients. Previously, fetal grafts have been shown to survive, integrate and induce functional recovery in PD patients. However, limited tissue availability has haltered the widespread use of this therapy and begs the demand for alternative tissue sources. In this regard, stem cells may constitute one such source. <i>Objective/Methods: </i>In this review we outline various types of stem cells currently available and provide an overview of their possible application for PD. We address not only the obvious possibility of using stem cells in cell replacement therapy but also the benefits of stem cell lines in drug discovery. <i>Results/Conclusion: </i>Stem cells carrying reporters or mutations in genes linked to familial PD are likely to contribute to the identification of new drug targets and subsequent development of new drugs for PD. Thus, stem cells are, and will be more so in the future, invaluable tools in the quest for new therapies against neurodegenerative diseases such as PD.
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