| 1. |
- Shroff, Sailee, et al.
(författare)
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Tree Species-Dependent Inactivation of Coronaviruses and Enteroviruses on Solid Wood Surfaces
- 2024
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 16:23, s. 29621-29633
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Tidskriftsartikel (refereegranskat)abstract
- The ongoing challenge of viral transmission, exemplified by the Covid pandemic and recurrent viral outbreaks, necessitates the exploration of sustainable antiviral solutions. This study investigates the underexplored antiviral potential of wooden surfaces. We evaluated the antiviral efficacy of various wood types, including coniferous and deciduous trees, against enveloped coronaviruses and nonenveloped enteroviruses like coxsackie virus A9. Our findings revealed excellent antiviral activity manifesting already within 10 to 15 min in Scots pine and Norway spruce, particularly against enveloped viruses. In contrast, other hardwoods displayed varied efficacy, with oak showing effectiveness against the enterovirus. This antiviral activity was consistently observed across a spectrum of humidity levels (20 to 90 RH%), while the antiviral efficacy manifested itself more rapidly at 37 degrees C vs 21 degrees C. Key to our findings is the chemical composition of these woods. Resin acids and terpenes were prevalent in pine and spruce, correlating with their antiviral performance, while oak's high phenolic content mirrored its efficacy against enterovirus. The pine surface absorbed a higher fraction of the coronavirus in contrast to oak, whereas enteroviruses were not absorbed on those surfaces. Thermal treatment of wood or mixing wood with plastic, such as in wood-plastic composites, strongly compromised the antiviral functionality of wood materials. This study highlights the role of bioactive chemicals in the antiviral action of wood and opens new avenues for employing wood surfaces as a natural and sustainable barrier against viral transmissions.
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| 2. |
- Ahokangas, Elina Marita, et al.
(författare)
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Geophysical characterization of late-Quaternary glaciofluvial complex and glacial stratigraphy in the Satakunta sandstone area, Köyliö, southwest Finland
- 2021
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Ingår i: Quaternary Research. - : Cambridge University Press. - 0033-5894 .- 1096-0287. ; 100, s. 135-153
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Tidskriftsartikel (refereegranskat)abstract
- We acquired high-resolution reflection seismic data using a broadband digital-based landstreamer system to characterize a depression related to the Mesoproterozoic (Jothnian) Satakunta sandstone basin in the Köyliö study area, southwest Finland. This ca. 800-m-wide depression is infilled with up to 100-m-thick (late) Quaternary interlobate glaciofluvial complex sediments. The seismic images clearly reveal details of the glaciofluvial complex, sandstone depression topography, and brittle structures related to the formation of the sandstone basin by oblique transtension. Additionally, we identified the setting of a diabase laccolith within the sandstone and the geometry and position of the steep sandstone contact. The esker core does not follow the sandstone-Svecofennian basement rock contact or lean to it. The esker core is at a depth of 50–60 m on the flank of the depression. The seismic data image the esker core and other architectural elements of the esker. We highlight the potential of the digital-based landstreamer in the research of complex Quaternary sediments in major bedrock depressions including the characterization of the underlying bedrock properties. We also discuss the possible tunnel valley origin of the sandstone depression.
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| 3. |
- Huusko, Johanna M, et al.
(författare)
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Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.
- 2021
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate activity of nuclear hormone receptors. Since SPTB has a significant genetic predisposition, our objective was to identify genetic and transcriptomic evidence of heat shock proteins and nuclear hormone receptors that may affect risk for SPTB. We investigated all 97 genes encoding members of the heat shock protein families and all 49 genes encoding nuclear hormone receptors for their potential role in SPTB susceptibility. We used multiple genetic and genomic datasets including genome-wide association studies (GWASs), whole-exome sequencing (WES), and placental transcriptomics to identify SPTB predisposing factors from the mother, infant, and placenta. There were multiple associations of heat shock protein and nuclear hormone receptor genes with SPTB. Several orthogonal datasets supported roles for SEC63, HSPA1L, SACS, RORA, and AR in susceptibility to SPTB. We propose that suppression of specific heat shock proteins promotes maintenance of pregnancy, whereas activation of specific heat shock protein mediated signaling may disturb maternal-fetal tolerance and promote labor.
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| 4. |
- Lahivaara, Timo, et al.
(författare)
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Estimation of groundwater storage from seismic data using deep learning
- 2019
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Ingår i: Geophysical Prospecting. - : WILEY. - 0016-8025 .- 1365-2478. ; 67:8, s. 2115-2126
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Tidskriftsartikel (refereegranskat)abstract
- Convolutional neural networks can provide a potential framework to characterize groundwater storage from seismic data. Estimation of key components, such as the amount of groundwater stored in an aquifer and delineate water table level, from active-source seismic data are performed in this study. The data to train, validate and test the neural networks are obtained by solving wave propagation in a coupled poroviscoelastic-elastic media. A discontinuous Galerkin method is applied to model wave propagation, whereas a deep convolutional neural network is used for the parameter estimation problem. In the numerical experiment, the primary unknowns estimated are the amount of stored groundwater and water table level, while the remaining parameters, assumed to be of less of interest, are marginalized in the convolutional neural network-based solution. Results, obtained through synthetic data, illustrate the potential of deep learning methods to extract additional aquifer information from seismic data, which otherwise would be impossible based on a set of reflection seismic sections or velocity tomograms.
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| 5. |
- Maries, Georgiana, et al.
(författare)
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Interlobate esker architecture and related hydrogeological features derived from a combination of high-resolution reflection seismics and refraction tomography, Virttaankangas, southwest Finland
- 2017
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Ingår i: Hydrogeology Journal. - : SPRINGER. - 1431-2174 .- 1435-0157. ; 25:3, s. 829-845
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Tidskriftsartikel (refereegranskat)abstract
- A novel high-resolution (2-4 m source and receiver spacing) reflection and refraction seismic survey was carried out for aquifer characterization and to confirm the existing depositional model of the interlobate esker of Virttaankangas, which is part of the Sakylanharju-Virttaankangas glaciofluvial esker-chain complex in southwest Finland. The interlobate esker complex hosting the managed aquifer recharge (MAR) plant is the source of the entire water supply for the city of Turku and its surrounding municipalities. An accurate delineation of the aquifer is therefore critical for long-term MAR planning and sustainable use of the esker resources. Moreover, an additional target was to resolve the poorly known stratigraphy of the 70-100-m-thick glacial deposits overlying a zone of fractured bedrock. Bedrock surface as well as fracture zones were confirmed through combined reflection seismic and refraction tomography results and further validated against existing borehole information. The high-resolution seismic data proved successful in accurately delineating the esker cores and revealing complex stratigraphy from fan lobes to kettle holes, providing valuable information for potential new pumping wells. This study illustrates the potential of geophysical methods for fast and cost-effective esker studies, in particular the digital-based landstreamer and its combination with geophone-based wireless recorders, where the cover sediments are reasonably thick.
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| 6. |
- Pasanen, Anu, et al.
(författare)
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Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.
- 2023
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Ingår i: PLoS genetics. - 1553-7404. ; 19:10
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Tidskriftsartikel (refereegranskat)abstract
- Preterm birth (<37 weeks of gestation) is a major cause of neonatal death and morbidity. Up to 40% of the variation in timing of birth results from genetic factors, mostly due to the maternal genome.We conducted a genome-wide meta-analysis of gestational duration and spontaneous preterm birth in 68,732 and 98,370 European mothers, respectively.The meta-analysis detected 15 loci associated with gestational duration, and four loci associated with preterm birth. Seven of the associated loci were novel. The loci mapped to several biologically plausible genes, for example HAND2 whose expression was previously shown to decrease during gestation, associated with gestational duration, and GC (Vitamin D-binding protein), associated with preterm birth. Downstream in silico-analysis suggested regulatory roles as underlying mechanisms for the associated loci. LD score regression found birth weight measures as the most strongly correlated traits, highlighting the unique nature of spontaneous preterm birth phenotype. Tissue expression and colocalization analysis revealed reproductive tissues and immune cell types as the most relevant sites of action.We report novel genetic risk loci that associate with preterm birth or gestational duration, and reproduce findings from previous genome-wide association studies. Altogether, our findings provide new insight into the genetic background of preterm birth. Better characterization of the causal genetic mechanisms will be important to public health as it could suggest new strategies to treat and prevent preterm birth.
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| 7. |
- Pasanen, Pirjo, et al.
(författare)
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EU FP6 IST-2003-507581 WINNER, D2.6 Assessment of Multiple Access Technologies, Oct 2004.
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The objective of this deliverable is to perform a first assessment of wireless access/multipleaccess technologies for the WINNER system concept. The study of multiple access schemes is theresponsibility of Task 4 within the WINNER workpackage 2. The work requires the collection andassessment of the numerous ideas and proposals available. The technologies and combinations oftechnologies are also assessed and compared, to identify the most promising strategies and combinations.The latter work is primarily performed by multi-link simulation and system-level simulation
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