| 1. |
- Allosso, Francesca, et al.
(författare)
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Mortality in patients with adrenal insufficiency: a protocol for a systematic review and meta-analysis.
- 2024
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Ingår i: BMJ open. - 2044-6055. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Adrenal insufficiency (AI) is a rare disorder characterised by an impaired secretion of glucocorticoids from the adrenal glands. Treatment strategies for AI have developed over time with reduced glucocorticoid replacement doses and improved circadian exposure regimens, but whether this has resulted in better survival is unknown. The main purpose of this systematic review is to gather and synthesise available evidence on long-term mortality in patients with AI. The secondary aim is to study causes of death, with focus on cardiovascular and infectious diseases, in AI patients.Studies published from the inception of respective databases (Medline, Embase, Cochrane and Web of Science) until the end of May 2023 will be systematically synthetised. Observational studies with a reference population will be included, and their quality will be assessed using the Newcastle-Ottawa scale. Data collected will be narratively integrated and a meta-analysis will be performed to pool data from studies considered homogeneous. The systematic review will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This will be the first systematic review assessing mortality and causes of death in AI patients. The findings of this systematic review will be of value for both patients and healthcare providers.This systematic review does not require ethical approval or informed consent because it will be based on previously published data only and does not implicate any direct contact with individual patients. The research results will be presented at scientific conferences and submitted for publication in an internationally recognised peer-reviewed scientific journal.CRD42023416253.
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| 2. |
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| 3. |
- Carpentier, Nico, et al.
(författare)
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The democratic (media) revolution : A parallel history of political and media participation
- 2014
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Ingår i: Audience transformations. - London : Routledge. - 9780415827362 ; , s. 123-141
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Bokkapitel (refereegranskat)abstract
- Participation is a central thematic within theories of democracy and points to questions of citizens' inclusion in decision-making. Taking a broad historical sweep, this chapter traces the genealogies of two intersecting fields: media participation and political participation, within the context of the Western democracies. The history of participation in media organisations begins with the power struggles in print media organisations in the 17th and 18th centuries, and continues into the 19th and 20th centuries, with the professionalisation of journalism, the emergence of alternative media, and the rise of the internet. The genealogy of political participation is an equally impressive account of struggles, setbacks and progress, and is inexorably linked to the establishment of democracy. Focusing on the 20th and 21st century, this chapter highlights the democratic revolution and the establishment of civic cultures in both societal fields, and how they interlock and strengthen each other, contributing to the gradual structural transformation of Western societies. While avoiding utopianism, the analysis retains a guarded optimism for the long-term, offering a counterpoint to the understandably troubled portraits of contemporary democracy. At the same time it also decidedly avoids any reductionist privileging of new media as ultimate sites of participation.
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| 4. |
- Carpentier, Nico, et al.
(författare)
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Waves of media democratization: A brief history of contemporary participatory practices in the media sphere
- 2013
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Ingår i: Convergence. - : SAGE Publications. - 1354-8565 .- 1748-7382. ; 19:3, s. 287-294
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Tidskriftsartikel (refereegranskat)abstract
- The article aims to provide a more historically grounded approach to the relationship between communication and participation, by distinguishing different waves of media democratization. The article first discusses the concept of participation and some of its complexities, and then sketches a series of intense moments of participation in and through the media in (mainly the second half) the 20th and the 21st century. At the same time, care is taken not to organize a linear-historical narrative, keeping in mind that the history of the democratization of Western societies and their media spheres is characterized by a series of continuities and discontinuities, dead ends and sedimented practices. Despite these ever-present fluctuations, the article argues that we can still see that structures, cultural resources and subjective dispositions have over time been geared more towards participation and equality, also within the media sphere.
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| 5. |
- Klein, Alison P., et al.
(författare)
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Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
- 2018
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
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