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| 2. |
- Berzisa, Solvita, et al.
(författare)
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Capability Driven Development : An Approach to Designing Digital Enterprises
- 2015
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Ingår i: Business & Information Systems Engineering. - : Springer Science and Business Media LLC. - 2363-7005 .- 1867-0202. ; 57:1, s. 15-25
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Tidskriftsartikel (refereegranskat)abstract
- The need for organizations to operate in changing environments is addressed by proposing an approach that integrates organizational development with information system (IS) development taking into account changes in the application context of the solution. This is referred to as Capability Driven Development (CDD). A meta-model representing business and IS designs consisting of goals, key performance indicators, capabilities, context and capability delivery patterns, is being proposed. The use of themeta-model is validated in three industrial case studies as part of an ongoing collaboration project, whereas one case is presented in the paper. Issues related to the use of the CDD approach, namely, CDD methodology and tool support are also discussed.
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- Carraminana, Albert, et al.
(författare)
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Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
- 2019
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Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - : W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.
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Conceptual Modeling : Proceedings
- 2015
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Proceedings (redaktörskap) (refereegranskat)abstract
- This book constitutes the refereed proceedings of the 34th International Conference on Conceptual Modeling, ER 2015, held in Stockholm, Sweden, in October 2015. The 26 full and 19 short papers presented were carefully reviewed and selected from 131 submissions. The papers are organized in topical sections on business process and goal models, ontology-based models and ontology patterns, constraints, normalization, interoperability and integration, collaborative modeling, variability and uncertainty modeling, modeling and visualization of user generated content, schema discovery and evolution, process and text mining, domain-based modeling, data models and semantics, and applications of conceptual modeling.
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| 7. |
- Escott-Price, Valentina, et al.
(författare)
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Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6, s. e94661-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
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| 8. |
- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 9. |
- Henkel, Martin, et al.
(författare)
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Capability Design with CDD
- 2018
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Ingår i: Capability Management in Digital Enterprises. - Cham : Springer. - 9783319904238 - 9783319904245 ; , s. 101-116
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Bokkapitel (refereegranskat)abstract
- One of the key tasks of the CDD methodology concerns designing capabilities starting from existing business requirements, enterprise models, and other kinds of organizational designs. As described in this chapter, the CDD methodology contains three complementary strategies for the design of capabilities: goal-first, process-first, and concept-first strategies. The view of the goal-first strategy is that capabilities exist as means to fulfill an organization’s long-term business objectives. The process-first strategy considers that capabilities are delivered through the execution of well-established business processes and therefore should be designed based on such processes. The concept-first strategy views stable information structures as the primary means for capability design. All three strategies for capability design shares four generic phases: scoping, identification, interlinking, and contextualizing and adapting. Each phase involves the use of some of the main CDD concepts in the capability design, such as goals, processes, context elements, or delivery patterns, as well as their relationships, with the final aim to obtain a well-defined model of one or several capabilities. Documentation of capabilities designed by the strategies is supported by the CDD environment, in particular the CDT tool support, a model-driven design.
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| 10. |
- Johannesson, Paul, et al.
(författare)
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Special issue on conceptual modeling – 34th International Conference on Conceptual Modeling (ER 2015)
- 2017
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Ingår i: Data & Knowledge Engineering. - : Elsevier BV. - 0169-023X .- 1872-6933. ; 107, s. 1-2
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We are happy to bring you this special issue of Data and Knowledge Engineering based on the 34th International Conference on Conceptual Modeling (ER 2015), which was held on 19–22 October 2015 in Stockholm, Sweden. Since 1979, when its first edition was held in Los Angeles, the ER conference has been the flagship conference series and the premier international meeting space for the Conceptual Modeling community. In 2015, the conference attracted 131 submissions from all parts of the world, 41 of which were accepted as long and short papers. The technical program also included four keynotes, nine workshops, five tutorials, a Ph.D. colloquium, a demo session, and a panel session. The conference covered a broad range of areas in conceptual modeling, from ontology-based modeling and data model semantics to conceptual modeling for big data and applications of modeling in health and social care.
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