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1.	Luis, TC, et al. (author) EMBRYONIC THYMOPOIESIS IS INITIATED BY AN IMMUNE-RESTRICTED LYMPHO-MYELOID PROGENITOR INDEPENDENTLY OF NOTCH SIGNALING 2016 In: EXPERIMENTAL HEMATOLOGY. - : Elsevier BV. - 0301-472X. ; 44:9, s. S65-S65 Conference paper (other academic/artistic)
2.	Luis, T, et al. (author) EMBRYONIC THYMOPOIESIS IS INITIATED BY AN IMMUNE-RESTRICTED LYMPHO-MYELOID PROGENITOR, INDEPENDENTLY OF NOTCH SIGNALING 2017 In: EXPERIMENTAL HEMATOLOGY. - 0301-472X. ; 53, s. S113-S114 Conference paper (other academic/artistic)
3.	Luis, Tiago C., et al. (author) Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors 2016 In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 17:12, s. 1424-1435 Journal article (peer-reviewed)abstract The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functional and molecular properties of embryonic thymopoiesis-initiating progenitors (T-IPs) before their entry into the thymus and activation of Notch signaling. T-IPs did not include multipotent stem cells or molecular evidence of T cell-restricted progenitors. Instead, single-cell molecular and functional analysis demonstrated that most fetal T-IPs expressed genes of and had the potential to develop into lymphoid as well as myeloid components of the immune system. Moreover, studies of embryos deficient in the transcriptional regulator RBPJ demonstrated that canonical Notch signaling was not involved in pre-thymic restriction to the T cell lineage or the migration of T-IPs.

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Type of publication: conference paper (2); journal article (1)

Type of content: other academic/artistic (2); peer-reviewed (1)

Author/Editor: Atkinson, D. (2); Sandberg, R (2); Woll, P (2); Azzoni, E (2); Carrelha, J (2); Nerlov, C (2); show more...; Jacobsen, SE (2); De Bruijn, M (2); Boukarabila, H (2); Luc, S (2); Boiers, C (2); Lutteropp, M (2); Mead, A (2); Bouriez-Jones, T (2); Thongjuea, S (2); Mizukami, T (2); Vaidya, H (2); Patient, R (2); Jacobsen, Sten Eirik ... (1); Sandberg, Rickard (1); Nerlov, Claus (1); Azzoni, Emanuele (1); Böiers, Charlotta (1); de Bruijn, Marella F ... (1); Luc, Sidinh (1); Macaulay, I (1); Luis, T (1); Geissmann, F (1); Giustacchini, A (1); Luis, TC (1); Lutteropp, Michael (1); Bouriez-Jones, Tipha ... (1); Carrelha, Joana (1); Woll, Petter S (1); Mead, Adam J (1); Macaulay, Iain C (1); Luis, Tiago C (1); Atkinson, Deborah (1); Geissmann, Frederic (1); Godin, Isabelle (1); Giustacchini, Alice (1); Thongjuea, Supat (1); Patient, Roger (1); Blackburn, C Clare (1); Blackburn, C (1); Macaulay, L. (1); Boukarabila, Hanane (1); Mizukami, Takuo (1); Vaidya, Harsh (1); Blackburn, CC (1); show less...

University: Karolinska Institutet (3); Lund University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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