| 1. |
|
|
| 2. |
- Grubler, Arnulf, et al.
(författare)
-
Energy Primer
- 2012
-
Ingår i: Global Energy Assessment - Toward a Sustainable Future. - 9781107005198 ; , s. 99-150
-
Bokkapitel (refereegranskat)
|
|
| 3. |
- Smith, Joel B., et al.
(författare)
-
Development and climate change adaptation funding : coordination and integration
- 2011
-
Ingår i: Climate Policy. - : Taylor & Francis. - 1469-3062 .- 1752-7457. ; 11:3, s. 987-1000
-
Tidskriftsartikel (refereegranskat)abstract
- Within a few decades, tens of billions, and possibly over a hundred billion, dollars will be needed for climate change adaptation in developing countries. In recent international climate negotiations, US$100 billion per year by 2020 was pledged by developed countries for mitigation and adaptation. Even if this pledge is realized, it is not clear that it will generate sufficient funds to address the adaptation needs of developing countries. A majority of what has been identified as climate change adaptation needs could be considered as funding for basic development. In addition, a large share of current development assistance is spent on climate-sensitive projects. With the potential for funding of climate change adaptation to fall short of what is needed and for development funding to continue funding many climate-sensitive activities, coordination of the two funding streams may enable more effective support for both sustainable development and climate change adaptation. Preliminary steps to facilitate such coordination are part of the Cancun Agreements and initiatives by other organizations.
|
|
| 4. |
|
|
| 5. |
- Grübler, Arnulf, et al.
(författare)
-
Policies for the Energy Technology Innovation System (ETIS)
- 2012
-
Ingår i: Global Energy Assessment: Toward a Sustainable Future. - 9780521182935 ; , s. 1665-1744
-
Bokkapitel (refereegranskat)abstract
- The development and introduction of heat pumps provides an interesting illustration of policy influence and effectiveness in relation to energy technology innovation. Heat pumps have been supported by several countries since the 1970s as a strategy to improve energy efficiency, support energy security, reduce environmental degradation, and combat climate change. Sweden and Switzerland have been essential to the development and commercialization of heat pumps in Europe. In both countries, numerous policy incentives have lined the path of technology and market development. Early policy initiatives were poorly coordinated but supported technology development, entrepreneurial experimentation, knowledge development, and the involvement of important actors in networks and organisations. The market collapse in the mid 1980s could have resulted in a total failure ‐ but did not. The research programmes continued in the 1980s, and a new set of stakeholders formed ‐ both publicly and privately funded researchers, authorities, and institutions ‐ and provided an important platform for further development. In the 1990s and 2000s, Sweden and Switzerland introduced more coordinated and strategic policy incentives for the development of heat pumps. The approaches were flexible and adjusted over time. The policy interventions in both countries supported learning, successful development and diffusion processes, and cost reductions. This assessment of innovation and diffusion policies for heat pump systems can be used to generalise some insights for energy technology innovation policy.
|
|
| 6. |
- Grudniewicz, A, et al.
(författare)
-
Predatory journals: no definition, no defence
- 2019
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 576:7786, s. 210-212
-
Tidskriftsartikel (refereegranskat)
|
|
| 7. |
- Lintner, KE, et al.
(författare)
-
Gene copy-number variations (CNVs) of complement C4 and C4A deficiency in genetic risk and pathogenesis of juvenile dermatomyositis
- 2016
-
Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 75:9, s. 1599-1606
-
Tidskriftsartikel (refereegranskat)abstract
- Complement-mediated vasculopathy of muscle and skin are clinical features of juvenile dermatomyositis (JDM). We assess gene copy-number variations (CNVs) for complement C4 and its isotypes, C4A and C4B, in genetic risks and pathogenesis of JDM.MethodsThe study population included 105 patients with JDM and 500 healthy European Americans. Gene copy-numbers (GCNs) for total C4, C4A, C4B and HLA-DRB1 genotypes were determined by Southern blots and qPCRs. Processed activation product C4d bound to erythrocytes (E-C4d) was measured by flow cytometry. Global gene-expression microarrays were performed in 19 patients with JDM and seven controls using PAXgene-blood RNA. Differential expression levels for selected genes were validated by qPCR.ResultsSignificantly lower GCNs and differences in distribution of GCN groups for total C4 and C4A were observed in JDM versus controls. Lower GCN of C4A in JDM remained among HLA DR3-positive subjects (p=0.015). Homozygous or heterozygous C4A-deficiency was present in 40.0% of patients with JDM compared with 18.2% of controls (OR=3.00 (1.87 to 4.79), p=8.2×10−6). Patients with JDM had higher levels of E-C4d than controls (p=0.004). In JDM, C4A-deficient subjects had higher levels of E-C4d (p=0.0003) and higher frequency of elevated levels of multiple serum muscle enzymes at diagnosis (p=0.0025). Microarray profiling of blood RNA revealed upregulation of type I interferon-stimulated genes and lower abundance of transcripts for T-cell and chemokine function genes in JDM, but this was less prominent among C4A-deficient or DR3-positive patients.ConclusionsComplement C4A deficiency appears to be an important factor for the genetic risk and pathogenesis of JDM, particularly in patients with a DR3-positive background.
|
|
| 8. |
- Ohmer, Christopher J., et al.
(författare)
-
XFEL serial crystallography reveals the room temperature structure of methyl-coenzyme M reductase
- 2022
-
Ingår i: Journal of Inorganic Biochemistry. - : Elsevier BV. - 0162-0134 .- 1873-3344. ; 230, s. 111768-
-
Tidskriftsartikel (refereegranskat)abstract
- Methyl-Coenzyme M Reductase (MCR) catalyzes the biosynthesis of methane in methanogenic archaea, using a catalytic Ni-centered Cofactor F430 in its active site. It also catalyzes the reverse reaction, that is, the anaerobic activation and oxidation, including the cleavage of the C-H bond in methane. Because methanogenesis is the major source of methane on earth, understanding the reaction mechanism of this enzyme can have massive implications in global energy balances. While recent publications have proposed a radical-based catalytic mechanism as well as novel sulfonate-based binding modes of MCR for its native substrates, the structure of the active state of MCR, as well as a complete characterization of the reaction, remain elusive. Previous attempts to structurally characterize the active MCR-Ni(I) state have been unsuccessful due to oxidation of the redox- sensitive catalytic Ni center. Further, while many cryo structures of the inactive Ni(II)-enzyme in various substrates bound forms have been published, no room temperature structures have been reported, and the structure and mechanism of MCR under physiologically relevant conditions is not known. In this study, we report the first room temperature structure of the MCRred1-silent Ni(II) form using an X-ray Free-Electron Laser (XFEL), with simultaneous X-ray Emission Spectroscopy (XES) and X-ray Diffraction (XRD) data collection. In celebration of the seminal contributions of inorganic chemist Dick Holm to our understanding of nickel-based catalysis, we are honored to announce our findings in this special issue dedicated to this remarkable pioneer of bioinorganic chemistry.
|
|
| 9. |
|
|
