| 1. |
- Paulides, M. M., et al.
(författare)
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ESHO benchmarks for computational modeling and optimization in hyperthermia therapy
- 2021
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Ingår i: International Journal of Hyperthermia. - : Informa UK Limited. - 0265-6736 .- 1464-5157. ; 38:1, s. 1425-1442
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Tidskriftsartikel (refereegranskat)abstract
- Background: The success of cancer hyperthermia (HT) treatments is strongly dependent on the temperatures achieved in the tumor and healthy tissues as it correlates with treatment efficacy and safety, respectively. Hyperthermia treatment planning (HTP) simulations have become pivotal for treatment optimization due to the possibility for pretreatment planning, optimization and decision making, as well as real-time treatment guidance. Materials and methods: The same computational methods deployed in HTP are also used for in silico studies. These are of great relevance for the development of new HT devices and treatment approaches. To aid this work, 3 D patient models have been recently developed and made available for the HT community. Unfortunately, there is no consensus regarding tissue properties, simulation settings, and benchmark applicators, which significantly influence the clinical relevance of computational outcomes. Results and discussion: Herein, we propose a comprehensive set of applicator benchmarks, efficacy and safety optimization algorithms, simulation settings and clinical parameters, to establish benchmarks for method comparison and code verification, to provide guidance, and in view of the 2021 ESHO Grand Challenge (Details on the ESHO grand challenge on HTP will be provided at https://www.esho.info/). Conclusion: We aim to establish guidelines to promote standardization within the hyperthermia community such that novel approaches can quickly prove their benefit as quickly as possible in clinically relevant simulation scenarios. This paper is primarily focused on radiofrequency and microwave hyperthermia but, since 3 D simulation studies on heating with ultrasound are now a reality, guidance as well as a benchmark for ultrasound-based hyperthermia are also included.
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| 2. |
- Paulides, M. M., et al.
(författare)
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Introduction to computational modeling in hyperthermia
- 2022
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Ingår i: International Journal of Hyperthermia. - : Informa UK Limited. - 0265-6736 .- 1464-5157. ; 39:1, s. 1358-1359
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Over the past two decades, computational modeling has gained a prominent role in hyperthermia research and its role for guiding treatments is expanding. Computational modeling serves e.g., to design new applicators, in silico testing of novel treatment approaches and providing insight in treatment safety. Hyperthermia treatment modeling and optimization (HTM&O), also known as hyperthermia treatment planning (HTP), is the process in which the multidisciplinary hyperthermia team defines the optimal treatment plan for a specific cancer patient using the available hyperthermia treatment resources. HTM&O includes computational modeling approaches for pretreatment HTP and online treatment guidance.
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| 3. |
- Paulides, M. M., et al.
(författare)
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Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery
- 2020
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Ingår i: Advanced Drug Delivery Reviews. - : Elsevier BV. - 0169-409X .- 1872-8294. ; 163-164, s. 3-18
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Forskningsöversikt (refereegranskat)abstract
- Hyperthermia therapy is a potent enhancer of chemotherapy and radiotherapy. In particular, microwave (MW) and radiofrequency (RF) hyperthermia devices provide a variety of heating approaches that can treat most cancers regardless the size. This review introduces the physics of MW/RF hyperthermia, the current state-of-the-art systems for both localized and regional heating, and recent advancements in hyperthermia treatment guidance using real-time computational simulations and magnetic resonance thermometry. Clinical trials involving RF/MW hyperthermia as adjuvant for chemotherapy are also presented per anatomical site. These studies favor the use of adjuvant hyperthermia since it significantly improves curative and palliative clinical outcomes. The main challenge of hyperthermia is the distribution of state-of-the-art heating systems. Nevertheless, we anticipate that recent technology advances will expand the use of hyperthermia to chemotherapy centers for enhanced drug delivery. These new technologies hold great promise not only for (image-guided) perfusion modulation and sensitization for cytotoxic drugs, but also for local delivery of various compounds using thermosensitive liposomes.
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| 4. |
- Rodrigues, Dario B., et al.
(författare)
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Radiofrequency and microwave hyperthermia in cancer treatment
- 2021
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Ingår i: Principles and Technologies for Electromagnetic Energy Based Therapies. ; , s. 281-311
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Hyperthermia therapy involves mild heating (40-44°C) that has been shown to be a potent enhancer of radiation and chemotherapy. Microwave (MW) and radiofrequency (RF) hyperthermia devices provide a variety of heating approaches that can treat most cancers regardless of their size and depth. This review introduces the physics of MW/RF hyperthermia, the current state-of-the-art systems for both local and regional heating, and recent advancements in hyperthermia treatment planning and guidance using real-time magnetic resonance imaging. The clinical evidence from clinical trials involving RF/MW hyperthermia as an adjuvant for radiation and chemotherapy is reviewed to show that adequate heating can be obtained with state-of-the-art systems. These studies strongly support the use of adjuvant hyperthermia as it significantly improves curative and palliative clinical outcomes. We anticipate that recent technology advances will improve the treatment delivery and reduce its complexity, as pivotal components for expanding the use of hyperthermia at medical and radiation oncology centers and enhancing cancer therapy.
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